Id |
Subject |
Object |
Predicate |
Lexical cue |
T3052 |
0-2 |
PRP |
denotes |
It |
T3053 |
12-17 |
VBN |
denotes |
shown |
T3054 |
3-6 |
VBZ |
denotes |
has |
T3055 |
7-11 |
VBN |
denotes |
been |
T3056 |
18-22 |
IN |
denotes |
that |
T3057 |
72-76 |
VBP |
denotes |
give |
T3058 |
23-30 |
NN |
denotes |
disease |
T3059 |
31-38 |
VBG |
denotes |
causing |
T3060 |
30-31 |
HYPH |
denotes |
- |
T3061 |
39-48 |
NNS |
denotes |
mutations |
T3062 |
49-51 |
IN |
denotes |
in |
T3063 |
52-55 |
DT |
denotes |
the |
T3064 |
67-71 |
NN |
denotes |
gene |
T3065 |
56-61 |
JJ |
denotes |
human |
T3066 |
62-66 |
NN |
denotes |
ATRX |
T3067 |
77-81 |
NN |
denotes |
rise |
T3068 |
82-84 |
IN |
denotes |
to |
T3069 |
85-92 |
NNS |
denotes |
changes |
T3070 |
93-95 |
IN |
denotes |
in |
T3071 |
96-99 |
DT |
denotes |
the |
T3072 |
107-114 |
NN |
denotes |
pattern |
T3073 |
100-106 |
JJ |
denotes |
normal |
T3074 |
115-117 |
IN |
denotes |
of |
T3075 |
118-121 |
NN |
denotes |
DNA |
T3076 |
122-133 |
NN |
denotes |
methylation |
T3077 |
134-136 |
IN |
denotes |
at |
T3078 |
137-144 |
JJ |
denotes |
several |
T3079 |
156-165 |
NNS |
denotes |
sequences |
T3080 |
145-155 |
JJ |
denotes |
repetitive |
T3081 |
166-172 |
IN |
denotes |
within |
T3082 |
173-176 |
DT |
denotes |
the |
T3083 |
183-189 |
NN |
denotes |
genome |
T3084 |
177-182 |
JJ |
denotes |
human |
T3085 |
190-191 |
-LRB- |
denotes |
[ |
T3086 |
191-193 |
CD |
denotes |
11 |
T3087 |
193-194 |
-RRB- |
denotes |
] |
T3088 |
194-195 |
. |
denotes |
. |
T3089 |
195-357 |
sentence |
denotes |
Notably, the transcribed region of the ribosomal DNA (rDNA) repeat was found to be significantly hypomethylated in ATR-X patients relative to normal individuals. |
T3090 |
196-203 |
RB |
denotes |
Notably |
T3091 |
267-272 |
VBN |
denotes |
found |
T3092 |
203-205 |
, |
denotes |
, |
T3093 |
205-208 |
DT |
denotes |
the |
T3094 |
221-227 |
NN |
denotes |
region |
T3095 |
209-220 |
VBN |
denotes |
transcribed |
T3096 |
228-230 |
IN |
denotes |
of |
T3097 |
231-234 |
DT |
denotes |
the |
T3098 |
256-262 |
NN |
denotes |
repeat |
T3099 |
235-244 |
JJ |
denotes |
ribosomal |
T3100 |
245-248 |
NN |
denotes |
DNA |
T3101 |
249-250 |
-LRB- |
denotes |
( |
T3102 |
250-254 |
NN |
denotes |
rDNA |
T3103 |
254-255 |
-RRB- |
denotes |
) |
T3104 |
263-266 |
VBD |
denotes |
was |
T3105 |
273-275 |
TO |
denotes |
to |
T3106 |
293-307 |
VBN |
denotes |
hypomethylated |
T3107 |
276-278 |
VB |
denotes |
be |
T3108 |
279-292 |
RB |
denotes |
significantly |
T3109 |
308-310 |
IN |
denotes |
in |
T3110 |
311-314 |
NN |
denotes |
ATR |
T3111 |
315-316 |
NN |
denotes |
X |
T3112 |
314-315 |
HYPH |
denotes |
- |
T3113 |
317-325 |
NNS |
denotes |
patients |
T3114 |
326-334 |
JJ |
denotes |
relative |
T3115 |
335-337 |
IN |
denotes |
to |
T3116 |
338-344 |
JJ |
denotes |
normal |
T3117 |
345-356 |
NNS |
denotes |
individuals |
T3118 |
356-357 |
. |
denotes |
. |
T3119 |
357-668 |
sentence |
denotes |
Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (Atrx WT or Atrx flox) (Figure 3B and 3C). |
T3120 |
358-363 |
VBG |
denotes |
Using |
T3121 |
415-423 |
VBD |
denotes |
observed |
T3122 |
364-375 |
NN |
denotes |
methylation |
T3123 |
376-385 |
JJ |
denotes |
sensitive |
T3124 |
375-376 |
HYPH |
denotes |
- |
T3125 |
398-405 |
NNS |
denotes |
enzymes |
T3126 |
386-397 |
NN |
denotes |
restriction |
T3127 |
405-407 |
, |
denotes |
, |
T3128 |
407-409 |
PRP |
denotes |
we |
T3129 |
410-414 |
RB |
denotes |
also |
T3130 |
424-435 |
JJ |
denotes |
significant |
T3131 |
436-451 |
NN |
denotes |
hypomethylation |
T3132 |
452-454 |
IN |
denotes |
at |
T3133 |
455-462 |
JJ |
denotes |
several |
T3134 |
463-468 |
NNS |
denotes |
sites |
T3135 |
469-475 |
VBN |
denotes |
tested |
T3136 |
476-482 |
IN |
denotes |
within |
T3137 |
483-486 |
DT |
denotes |
the |
T3138 |
498-505 |
NNS |
denotes |
repeats |
T3139 |
487-492 |
NN |
denotes |
mouse |
T3140 |
493-497 |
NN |
denotes |
rDNA |
T3141 |
506-508 |
IN |
denotes |
in |
T3142 |
509-517 |
JJ |
denotes |
Atrxnull |
T3143 |
521-526 |
NNS |
denotes |
cells |
T3144 |
518-520 |
NN |
denotes |
ES |
T3145 |
527-530 |
CC |
denotes |
and |
T3146 |
531-533 |
CD |
denotes |
12 |
T3147 |
534-535 |
NN |
denotes |
d |
T3148 |
533-534 |
HYPH |
denotes |
- |
T3149 |
545-551 |
NNS |
denotes |
bodies |
T3150 |
536-544 |
JJ |
denotes |
embryoid |
T3151 |
552-560 |
JJ |
denotes |
relative |
T3152 |
561-563 |
IN |
denotes |
to |
T3153 |
564-566 |
NN |
denotes |
ES |
T3154 |
567-572 |
NNS |
denotes |
cells |
T3155 |
573-576 |
CC |
denotes |
and |
T3156 |
577-585 |
JJ |
denotes |
embryoid |
T3157 |
586-592 |
NNS |
denotes |
bodies |
T3158 |
593-600 |
VBG |
denotes |
bearing |
T3159 |
601-602 |
DT |
denotes |
a |
T3160 |
619-625 |
NN |
denotes |
allele |
T3161 |
603-613 |
JJ |
denotes |
functional |
T3162 |
614-618 |
NN |
denotes |
Atrx |
T3163 |
626-627 |
-LRB- |
denotes |
( |
T3164 |
627-634 |
NN |
denotes |
Atrx WT |
T3165 |
635-637 |
CC |
denotes |
or |
T3166 |
638-647 |
NN |
denotes |
Atrx flox |
T3167 |
647-648 |
-RRB- |
denotes |
) |
T3168 |
649-650 |
-LRB- |
denotes |
( |
T3169 |
657-659 |
NN |
denotes |
3B |
T3170 |
650-656 |
NN |
denotes |
Figure |
T3171 |
660-663 |
CC |
denotes |
and |
T3172 |
664-666 |
NN |
denotes |
3C |
T3173 |
666-667 |
-RRB- |
denotes |
) |
T3174 |
667-668 |
. |
denotes |
. |
T3175 |
668-899 |
sentence |
denotes |
The observation that rDNA is hypomethylated in the absence of Atrx, even in ES cells, is consistent with the finding that hypomethylation of the human rDNA repeats is detectable from an early developmental stage in ATR-X patients. |
T3176 |
669-672 |
DT |
denotes |
The |
T3177 |
673-684 |
NN |
denotes |
observation |
T3178 |
755-757 |
VBZ |
denotes |
is |
T3179 |
685-689 |
IN |
denotes |
that |
T3180 |
698-712 |
VBN |
denotes |
hypomethylated |
T3181 |
690-694 |
NN |
denotes |
rDNA |
T3182 |
695-697 |
VBZ |
denotes |
is |
T3183 |
713-715 |
IN |
denotes |
in |
T3184 |
716-719 |
DT |
denotes |
the |
T3185 |
720-727 |
NN |
denotes |
absence |
T3186 |
728-730 |
IN |
denotes |
of |
T3187 |
731-735 |
NN |
denotes |
Atrx |
T3188 |
735-737 |
, |
denotes |
, |
T3189 |
737-741 |
RB |
denotes |
even |
T3190 |
742-744 |
IN |
denotes |
in |
T3191 |
745-747 |
NN |
denotes |
ES |
T3192 |
748-753 |
NNS |
denotes |
cells |
T3193 |
753-755 |
, |
denotes |
, |
T3194 |
758-768 |
JJ |
denotes |
consistent |
T3195 |
769-773 |
IN |
denotes |
with |
T3196 |
774-777 |
DT |
denotes |
the |
T3197 |
778-785 |
NN |
denotes |
finding |
T3198 |
786-790 |
IN |
denotes |
that |
T3199 |
833-835 |
VBZ |
denotes |
is |
T3200 |
791-806 |
NN |
denotes |
hypomethylation |
T3201 |
807-809 |
IN |
denotes |
of |
T3202 |
810-813 |
DT |
denotes |
the |
T3203 |
825-832 |
NNS |
denotes |
repeats |
T3204 |
814-819 |
JJ |
denotes |
human |
T3205 |
820-824 |
NN |
denotes |
rDNA |
T3206 |
836-846 |
JJ |
denotes |
detectable |
T3207 |
847-851 |
IN |
denotes |
from |
T3208 |
852-854 |
DT |
denotes |
an |
T3209 |
875-880 |
NN |
denotes |
stage |
T3210 |
855-860 |
JJ |
denotes |
early |
T3211 |
861-874 |
JJ |
denotes |
developmental |
T3212 |
881-883 |
IN |
denotes |
in |
T3213 |
884-887 |
NN |
denotes |
ATR |
T3214 |
888-889 |
NN |
denotes |
X |
T3215 |
887-888 |
HYPH |
denotes |
- |
T3216 |
890-898 |
NNS |
denotes |
patients |
T3217 |
898-899 |
. |
denotes |
. |
T3218 |
899-1228 |
sentence |
denotes |
Other mouse repetitive sequence elements surveyed in ES cell DNA include the heterochromatic major satellite (assayed with MaeII) and minor satellite (assayed with HpaII) repeats, as well as interspersed retroviral repeats of the intracisternal A particle (IAP) type and the Line 1 and Sine B1 families (all assayed with HpaII). |
T3219 |
900-905 |
JJ |
denotes |
Other |
T3220 |
932-940 |
NNS |
denotes |
elements |
T3221 |
906-911 |
NN |
denotes |
mouse |
T3222 |
912-922 |
JJ |
denotes |
repetitive |
T3223 |
923-931 |
NN |
denotes |
sequence |
T3224 |
965-972 |
VBP |
denotes |
include |
T3225 |
941-949 |
VBN |
denotes |
surveyed |
T3226 |
950-952 |
IN |
denotes |
in |
T3227 |
953-955 |
NN |
denotes |
ES |
T3228 |
961-964 |
NN |
denotes |
DNA |
T3229 |
956-960 |
NN |
denotes |
cell |
T3230 |
973-976 |
DT |
denotes |
the |
T3231 |
1071-1078 |
NNS |
denotes |
repeats |
T3232 |
977-992 |
JJ |
denotes |
heterochromatic |
T3233 |
999-1008 |
NN |
denotes |
satellite |
T3234 |
993-998 |
JJ |
denotes |
major |
T3235 |
1009-1010 |
-LRB- |
denotes |
( |
T3236 |
1010-1017 |
VBN |
denotes |
assayed |
T3237 |
1018-1022 |
IN |
denotes |
with |
T3238 |
1023-1028 |
NN |
denotes |
MaeII |
T3239 |
1028-1029 |
-RRB- |
denotes |
) |
T3240 |
1030-1033 |
CC |
denotes |
and |
T3241 |
1034-1039 |
JJ |
denotes |
minor |
T3242 |
1040-1049 |
NN |
denotes |
satellite |
T3243 |
1050-1051 |
-LRB- |
denotes |
( |
T3244 |
1051-1058 |
VBN |
denotes |
assayed |
T3245 |
1059-1063 |
IN |
denotes |
with |
T3246 |
1064-1069 |
NN |
denotes |
HpaII |
T3247 |
1069-1070 |
-RRB- |
denotes |
) |
T3248 |
1078-1080 |
, |
denotes |
, |
T3249 |
1080-1082 |
RB |
denotes |
as |
T3250 |
1088-1090 |
IN |
denotes |
as |
T3251 |
1083-1087 |
RB |
denotes |
well |
T3252 |
1091-1103 |
VBN |
denotes |
interspersed |
T3253 |
1115-1122 |
NNS |
denotes |
repeats |
T3254 |
1104-1114 |
JJ |
denotes |
retroviral |
T3255 |
1123-1125 |
IN |
denotes |
of |
T3256 |
1126-1129 |
DT |
denotes |
the |
T3257 |
1162-1166 |
NN |
denotes |
type |
T3258 |
1130-1144 |
JJ |
denotes |
intracisternal |
T3259 |
1147-1155 |
NN |
denotes |
particle |
T3260 |
1145-1146 |
NN |
denotes |
A |
T3261 |
1156-1157 |
-LRB- |
denotes |
( |
T3262 |
1157-1160 |
NN |
denotes |
IAP |
T3263 |
1160-1161 |
-RRB- |
denotes |
) |
T3264 |
1167-1170 |
CC |
denotes |
and |
T3265 |
1171-1174 |
DT |
denotes |
the |
T3266 |
1194-1202 |
NNS |
denotes |
families |
T3267 |
1175-1179 |
NN |
denotes |
Line |
T3268 |
1180-1181 |
CD |
denotes |
1 |
T3269 |
1182-1185 |
CC |
denotes |
and |
T3270 |
1186-1190 |
NN |
denotes |
Sine |
T3271 |
1191-1193 |
NN |
denotes |
B1 |
T3272 |
1203-1204 |
-LRB- |
denotes |
( |
T3273 |
1204-1207 |
DT |
denotes |
all |
T3274 |
1208-1215 |
VBN |
denotes |
assayed |
T3275 |
1216-1220 |
IN |
denotes |
with |
T3276 |
1221-1226 |
NN |
denotes |
HpaII |
T3277 |
1226-1227 |
-RRB- |
denotes |
) |
T3278 |
1227-1228 |
. |
denotes |
. |
T3279 |
1228-1482 |
sentence |
denotes |
These repeats were found to be moderately (Line 1 and Sine B1) or highly (IAP, major satellite, minor satellite) methylated in wild-type ES cells, and this methylation was not detectably perturbed by the absence of Atrx (Figure S3 and unpublished data). |
T3280 |
1229-1234 |
DT |
denotes |
These |
T3281 |
1235-1242 |
NNS |
denotes |
repeats |
T3282 |
1248-1253 |
VBN |
denotes |
found |
T3283 |
1243-1247 |
VBD |
denotes |
were |
T3284 |
1254-1256 |
TO |
denotes |
to |
T3285 |
1257-1259 |
VB |
denotes |
be |
T3286 |
1260-1270 |
RB |
denotes |
moderately |
T3287 |
1342-1352 |
JJ |
denotes |
methylated |
T3288 |
1271-1272 |
-LRB- |
denotes |
( |
T3289 |
1272-1276 |
NN |
denotes |
Line |
T3290 |
1277-1278 |
CD |
denotes |
1 |
T3291 |
1279-1282 |
CC |
denotes |
and |
T3292 |
1283-1287 |
NN |
denotes |
Sine |
T3293 |
1288-1290 |
NN |
denotes |
B1 |
T3294 |
1290-1291 |
-RRB- |
denotes |
) |
T3295 |
1292-1294 |
CC |
denotes |
or |
T3296 |
1295-1301 |
RB |
denotes |
highly |
T3297 |
1302-1303 |
-LRB- |
denotes |
( |
T3298 |
1303-1306 |
NN |
denotes |
IAP |
T3299 |
1306-1308 |
, |
denotes |
, |
T3300 |
1308-1313 |
JJ |
denotes |
major |
T3301 |
1314-1323 |
NN |
denotes |
satellite |
T3302 |
1323-1325 |
, |
denotes |
, |
T3303 |
1325-1330 |
JJ |
denotes |
minor |
T3304 |
1331-1340 |
NN |
denotes |
satellite |
T3305 |
1340-1341 |
-RRB- |
denotes |
) |
T3306 |
1353-1355 |
IN |
denotes |
in |
T3307 |
1356-1360 |
JJ |
denotes |
wild |
T3308 |
1361-1365 |
NN |
denotes |
type |
T3309 |
1360-1361 |
HYPH |
denotes |
- |
T3310 |
1369-1374 |
NNS |
denotes |
cells |
T3311 |
1366-1368 |
NN |
denotes |
ES |
T3312 |
1374-1376 |
, |
denotes |
, |
T3313 |
1376-1379 |
CC |
denotes |
and |
T3314 |
1380-1384 |
DT |
denotes |
this |
T3315 |
1385-1396 |
NN |
denotes |
methylation |
T3316 |
1416-1425 |
VBN |
denotes |
perturbed |
T3317 |
1397-1400 |
VBD |
denotes |
was |
T3318 |
1401-1404 |
RB |
denotes |
not |
T3319 |
1405-1415 |
RB |
denotes |
detectably |
T3320 |
1426-1428 |
IN |
denotes |
by |
T3321 |
1429-1432 |
DT |
denotes |
the |
T3322 |
1433-1440 |
NN |
denotes |
absence |
T3323 |
1441-1443 |
IN |
denotes |
of |
T3324 |
1444-1448 |
NN |
denotes |
Atrx |
T3325 |
1449-1450 |
-LRB- |
denotes |
( |
T3326 |
1457-1459 |
NN |
denotes |
S3 |
T3327 |
1450-1456 |
NN |
denotes |
Figure |
T3328 |
1460-1463 |
CC |
denotes |
and |
T3329 |
1464-1475 |
JJ |
denotes |
unpublished |
T3330 |
1476-1480 |
NNS |
denotes |
data |
T3331 |
1480-1481 |
-RRB- |
denotes |
) |
T3332 |
1481-1482 |
. |
denotes |
. |
T3333 |
1482-1648 |
sentence |
denotes |
Taken together, these data indicate that the subtle interplay between the ATRX protein and DNA methylation observed in human patients is also present in mouse cells. |
T3334 |
1483-1488 |
VBN |
denotes |
Taken |
T3335 |
1510-1518 |
VBP |
denotes |
indicate |
T3336 |
1489-1497 |
RB |
denotes |
together |
T3337 |
1497-1499 |
, |
denotes |
, |
T3338 |
1499-1504 |
DT |
denotes |
these |
T3339 |
1505-1509 |
NNS |
denotes |
data |
T3340 |
1519-1523 |
IN |
denotes |
that |
T3341 |
1617-1619 |
VBZ |
denotes |
is |
T3342 |
1524-1527 |
DT |
denotes |
the |
T3343 |
1535-1544 |
NN |
denotes |
interplay |
T3344 |
1528-1534 |
JJ |
denotes |
subtle |
T3345 |
1545-1552 |
IN |
denotes |
between |
T3346 |
1553-1556 |
DT |
denotes |
the |
T3347 |
1562-1569 |
NN |
denotes |
protein |
T3348 |
1557-1561 |
NN |
denotes |
ATRX |
T3349 |
1570-1573 |
CC |
denotes |
and |
T3350 |
1574-1577 |
NN |
denotes |
DNA |
T3351 |
1578-1589 |
NN |
denotes |
methylation |
T3352 |
1590-1598 |
VBN |
denotes |
observed |
T3353 |
1599-1601 |
IN |
denotes |
in |
T3354 |
1602-1607 |
JJ |
denotes |
human |
T3355 |
1608-1616 |
NNS |
denotes |
patients |
T3356 |
1620-1624 |
RB |
denotes |
also |
T3357 |
1625-1632 |
JJ |
denotes |
present |
T3358 |
1633-1635 |
IN |
denotes |
in |
T3359 |
1636-1641 |
NN |
denotes |
mouse |
T3360 |
1642-1647 |
NNS |
denotes |
cells |
T3361 |
1647-1648 |
. |
denotes |
. |
R1801 |
T3052 |
T3053 |
nsubjpass |
It,shown |
R1802 |
T3054 |
T3053 |
aux |
has,shown |
R1803 |
T3055 |
T3053 |
auxpass |
been,shown |
R1804 |
T3056 |
T3057 |
mark |
that,give |
R1805 |
T3057 |
T3053 |
ccomp |
give,shown |
R1806 |
T3058 |
T3059 |
npadvmod |
disease,causing |
R1807 |
T3059 |
T3061 |
amod |
causing,mutations |
R1808 |
T3060 |
T3059 |
punct |
-,causing |
R1809 |
T3061 |
T3057 |
nsubj |
mutations,give |
R1810 |
T3062 |
T3061 |
prep |
in,mutations |
R1811 |
T3063 |
T3064 |
det |
the,gene |
R1812 |
T3064 |
T3062 |
pobj |
gene,in |
R1813 |
T3065 |
T3064 |
amod |
human,gene |
R1814 |
T3066 |
T3064 |
compound |
ATRX,gene |
R1815 |
T3067 |
T3057 |
dobj |
rise,give |
R1816 |
T3068 |
T3057 |
prep |
to,give |
R1817 |
T3069 |
T3068 |
pobj |
changes,to |
R1818 |
T3070 |
T3069 |
prep |
in,changes |
R1819 |
T3071 |
T3072 |
det |
the,pattern |
R1820 |
T3072 |
T3070 |
pobj |
pattern,in |
R1821 |
T3073 |
T3072 |
amod |
normal,pattern |
R1822 |
T3074 |
T3072 |
prep |
of,pattern |
R1823 |
T3075 |
T3076 |
compound |
DNA,methylation |
R1824 |
T3076 |
T3074 |
pobj |
methylation,of |
R1825 |
T3077 |
T3069 |
prep |
at,changes |
R1826 |
T3078 |
T3079 |
amod |
several,sequences |
R1827 |
T3079 |
T3077 |
pobj |
sequences,at |
R1828 |
T3080 |
T3079 |
amod |
repetitive,sequences |
R1829 |
T3081 |
T3079 |
prep |
within,sequences |
R1830 |
T3082 |
T3083 |
det |
the,genome |
R1831 |
T3083 |
T3081 |
pobj |
genome,within |
R1832 |
T3084 |
T3083 |
amod |
human,genome |
R1833 |
T3085 |
T3086 |
punct |
[,11 |
R1834 |
T3086 |
T3057 |
parataxis |
11,give |
R1835 |
T3087 |
T3086 |
punct |
],11 |
R1836 |
T3088 |
T3053 |
punct |
.,shown |
R1837 |
T3090 |
T3091 |
advmod |
Notably,found |
R1838 |
T3092 |
T3091 |
punct |
", ",found |
R1839 |
T3093 |
T3094 |
det |
the,region |
R1840 |
T3094 |
T3091 |
nsubjpass |
region,found |
R1841 |
T3095 |
T3094 |
amod |
transcribed,region |
R1842 |
T3096 |
T3094 |
prep |
of,region |
R1843 |
T3097 |
T3098 |
det |
the,repeat |
R1844 |
T3098 |
T3096 |
pobj |
repeat,of |
R1845 |
T3099 |
T3100 |
amod |
ribosomal,DNA |
R1846 |
T3100 |
T3098 |
nmod |
DNA,repeat |
R1847 |
T3101 |
T3100 |
punct |
(,DNA |
R1848 |
T3102 |
T3100 |
appos |
rDNA,DNA |
R1849 |
T3103 |
T3098 |
punct |
),repeat |
R1850 |
T3104 |
T3091 |
auxpass |
was,found |
R1851 |
T3105 |
T3106 |
aux |
to,hypomethylated |
R1852 |
T3106 |
T3091 |
xcomp |
hypomethylated,found |
R1853 |
T3107 |
T3106 |
auxpass |
be,hypomethylated |
R1854 |
T3108 |
T3106 |
advmod |
significantly,hypomethylated |
R1855 |
T3109 |
T3106 |
prep |
in,hypomethylated |
R1856 |
T3110 |
T3111 |
compound |
ATR,X |
R1857 |
T3111 |
T3113 |
compound |
X,patients |
R1858 |
T3112 |
T3111 |
punct |
-,X |
R1859 |
T3113 |
T3109 |
pobj |
patients,in |
R1860 |
T3114 |
T3106 |
advcl |
relative,hypomethylated |
R1861 |
T3115 |
T3114 |
prep |
to,relative |
R1862 |
T3116 |
T3117 |
amod |
normal,individuals |
R1863 |
T3117 |
T3115 |
pobj |
individuals,to |
R1864 |
T3118 |
T3091 |
punct |
.,found |
R1865 |
T3120 |
T3121 |
advcl |
Using,observed |
R1866 |
T3122 |
T3123 |
npadvmod |
methylation,sensitive |
R1867 |
T3123 |
T3125 |
amod |
sensitive,enzymes |
R1868 |
T3124 |
T3123 |
punct |
-,sensitive |
R1869 |
T3125 |
T3120 |
dobj |
enzymes,Using |
R1870 |
T3126 |
T3125 |
compound |
restriction,enzymes |
R1871 |
T3127 |
T3121 |
punct |
", ",observed |
R1872 |
T3128 |
T3121 |
nsubj |
we,observed |
R1873 |
T3129 |
T3121 |
advmod |
also,observed |
R1874 |
T3130 |
T3131 |
amod |
significant,hypomethylation |
R1875 |
T3131 |
T3121 |
dobj |
hypomethylation,observed |
R1876 |
T3132 |
T3121 |
prep |
at,observed |
R1877 |
T3133 |
T3134 |
amod |
several,sites |
R1878 |
T3134 |
T3132 |
pobj |
sites,at |
R1879 |
T3135 |
T3134 |
acl |
tested,sites |
R1880 |
T3136 |
T3135 |
prep |
within,tested |
R1881 |
T3137 |
T3138 |
det |
the,repeats |
R1882 |
T3138 |
T3136 |
pobj |
repeats,within |
R1883 |
T3139 |
T3140 |
compound |
mouse,rDNA |
R1884 |
T3140 |
T3138 |
compound |
rDNA,repeats |
R1885 |
T3141 |
T3138 |
prep |
in,repeats |
R1886 |
T3142 |
T3143 |
amod |
Atrxnull,cells |
R1887 |
T3143 |
T3141 |
pobj |
cells,in |
R1888 |
T3144 |
T3143 |
compound |
ES,cells |
R1889 |
T3145 |
T3143 |
cc |
and,cells |
R1890 |
T3146 |
T3147 |
nummod |
12,d |
R1891 |
T3147 |
T3149 |
nmod |
d,bodies |
R1892 |
T3148 |
T3147 |
punct |
-,d |
R1893 |
T3149 |
T3143 |
conj |
bodies,cells |
R1894 |
T3150 |
T3149 |
amod |
embryoid,bodies |
R1895 |
T3151 |
T3121 |
advcl |
relative,observed |
R1896 |
T3152 |
T3151 |
prep |
to,relative |
R1897 |
T3153 |
T3154 |
compound |
ES,cells |
R1898 |
T3154 |
T3152 |
pobj |
cells,to |
R1899 |
T3155 |
T3154 |
cc |
and,cells |
R1900 |
T3156 |
T3157 |
amod |
embryoid,bodies |
R1901 |
T3157 |
T3154 |
conj |
bodies,cells |
R1902 |
T3158 |
T3154 |
acl |
bearing,cells |
R1903 |
T3159 |
T3160 |
det |
a,allele |
R1904 |
T3160 |
T3158 |
dobj |
allele,bearing |
R1905 |
T3161 |
T3160 |
amod |
functional,allele |
R1906 |
T3162 |
T3160 |
compound |
Atrx,allele |
R1907 |
T3163 |
T3160 |
punct |
(,allele |
R1908 |
T3164 |
T3160 |
appos |
Atrx WT,allele |
R1909 |
T3165 |
T3164 |
cc |
or,Atrx WT |
R1910 |
T3166 |
T3164 |
conj |
Atrx flox,Atrx WT |
R1911 |
T3167 |
T3121 |
punct |
),observed |
R1912 |
T3168 |
T3169 |
punct |
(,3B |
R1913 |
T3169 |
T3121 |
parataxis |
3B,observed |
R1914 |
T3170 |
T3169 |
compound |
Figure,3B |
R1915 |
T3171 |
T3169 |
cc |
and,3B |
R1916 |
T3172 |
T3169 |
conj |
3C,3B |
R1917 |
T3173 |
T3169 |
punct |
),3B |
R1918 |
T3174 |
T3121 |
punct |
.,observed |
R1919 |
T3176 |
T3177 |
det |
The,observation |
R1920 |
T3177 |
T3178 |
nsubj |
observation,is |
R1921 |
T3179 |
T3180 |
mark |
that,hypomethylated |
R1922 |
T3180 |
T3177 |
acl |
hypomethylated,observation |
R1923 |
T3181 |
T3180 |
nsubjpass |
rDNA,hypomethylated |
R1924 |
T3182 |
T3180 |
auxpass |
is,hypomethylated |
R1925 |
T3183 |
T3180 |
prep |
in,hypomethylated |
R1926 |
T3184 |
T3185 |
det |
the,absence |
R1927 |
T3185 |
T3183 |
pobj |
absence,in |
R1928 |
T3186 |
T3185 |
prep |
of,absence |
R1929 |
T3187 |
T3186 |
pobj |
Atrx,of |
R1930 |
T3188 |
T3180 |
punct |
", ",hypomethylated |
R1931 |
T3189 |
T3190 |
advmod |
even,in |
R1932 |
T3190 |
T3180 |
prep |
in,hypomethylated |
R1933 |
T3191 |
T3192 |
compound |
ES,cells |
R1934 |
T3192 |
T3190 |
pobj |
cells,in |
R1935 |
T3193 |
T3178 |
punct |
", ",is |
R1936 |
T3194 |
T3178 |
acomp |
consistent,is |
R1937 |
T3195 |
T3194 |
prep |
with,consistent |
R1938 |
T3196 |
T3197 |
det |
the,finding |
R1939 |
T3197 |
T3195 |
pobj |
finding,with |
R1940 |
T3198 |
T3199 |
mark |
that,is |
R1941 |
T3199 |
T3197 |
acl |
is,finding |
R1942 |
T3200 |
T3199 |
nsubj |
hypomethylation,is |
R1943 |
T3201 |
T3200 |
prep |
of,hypomethylation |
R1944 |
T3202 |
T3203 |
det |
the,repeats |
R1945 |
T3203 |
T3201 |
pobj |
repeats,of |
R1946 |
T3204 |
T3205 |
amod |
human,rDNA |
R1947 |
T3205 |
T3203 |
compound |
rDNA,repeats |
R1948 |
T3206 |
T3199 |
acomp |
detectable,is |
R1949 |
T3207 |
T3199 |
prep |
from,is |
R1950 |
T3208 |
T3209 |
det |
an,stage |
R1951 |
T3209 |
T3207 |
pobj |
stage,from |
R1952 |
T3210 |
T3209 |
amod |
early,stage |
R1953 |
T3211 |
T3209 |
amod |
developmental,stage |
R1954 |
T3212 |
T3199 |
prep |
in,is |
R1955 |
T3213 |
T3214 |
compound |
ATR,X |
R1956 |
T3214 |
T3216 |
compound |
X,patients |
R1957 |
T3215 |
T3214 |
punct |
-,X |
R1958 |
T3216 |
T3212 |
pobj |
patients,in |
R1959 |
T3217 |
T3178 |
punct |
.,is |
R1960 |
T3219 |
T3220 |
amod |
Other,elements |
R1961 |
T3220 |
T3224 |
nsubj |
elements,include |
R1962 |
T3221 |
T3220 |
nmod |
mouse,elements |
R1963 |
T3222 |
T3223 |
amod |
repetitive,sequence |
R1964 |
T3223 |
T3220 |
compound |
sequence,elements |
R1965 |
T3225 |
T3220 |
acl |
surveyed,elements |
R1966 |
T3226 |
T3225 |
prep |
in,surveyed |
R1967 |
T3227 |
T3228 |
compound |
ES,DNA |
R1968 |
T3228 |
T3226 |
pobj |
DNA,in |
R1969 |
T3229 |
T3228 |
compound |
cell,DNA |
R1970 |
T3230 |
T3231 |
det |
the,repeats |
R1971 |
T3231 |
T3224 |
dobj |
repeats,include |
R1972 |
T3232 |
T3233 |
amod |
heterochromatic,satellite |
R1973 |
T3233 |
T3231 |
nmod |
satellite,repeats |
R1974 |
T3234 |
T3233 |
amod |
major,satellite |
R1975 |
T3235 |
T3236 |
punct |
(,assayed |
R1976 |
T3236 |
T3233 |
parataxis |
assayed,satellite |
R1977 |
T3237 |
T3236 |
prep |
with,assayed |
R1978 |
T3238 |
T3237 |
pobj |
MaeII,with |
R1979 |
T3239 |
T3236 |
punct |
),assayed |
R1980 |
T3240 |
T3233 |
cc |
and,satellite |
R1981 |
T3241 |
T3242 |
amod |
minor,satellite |
R1982 |
T3242 |
T3233 |
conj |
satellite,satellite |
R1983 |
T3243 |
T3244 |
punct |
(,assayed |
R1984 |
T3244 |
T3242 |
parataxis |
assayed,satellite |
R1985 |
T3245 |
T3244 |
prep |
with,assayed |
R1986 |
T3246 |
T3245 |
pobj |
HpaII,with |
R1987 |
T3247 |
T3244 |
punct |
),assayed |
R1988 |
T3248 |
T3231 |
punct |
", ",repeats |
R1989 |
T3249 |
T3250 |
advmod |
as,as |
R1990 |
T3250 |
T3231 |
cc |
as,repeats |
R1991 |
T3251 |
T3250 |
advmod |
well,as |
R1992 |
T3252 |
T3253 |
amod |
interspersed,repeats |
R1993 |
T3253 |
T3231 |
conj |
repeats,repeats |
R1994 |
T3254 |
T3253 |
amod |
retroviral,repeats |
R1995 |
T3255 |
T3253 |
prep |
of,repeats |
R1996 |
T3256 |
T3257 |
det |
the,type |
R1997 |
T3257 |
T3255 |
pobj |
type,of |
R1998 |
T3258 |
T3259 |
amod |
intracisternal,particle |
R1999 |
T3259 |
T3257 |
nmod |
particle,type |
R2000 |
T3260 |
T3259 |
nmod |
A,particle |
R2001 |
T3261 |
T3259 |
punct |
(,particle |
R2002 |
T3262 |
T3259 |
appos |
IAP,particle |
R2003 |
T3263 |
T3257 |
punct |
),type |
R2004 |
T3264 |
T3257 |
cc |
and,type |
R2005 |
T3265 |
T3266 |
det |
the,families |
R2006 |
T3266 |
T3257 |
conj |
families,type |
R2007 |
T3267 |
T3266 |
nmod |
Line,families |
R2008 |
T3268 |
T3267 |
nummod |
1,Line |
R2009 |
T3269 |
T3267 |
cc |
and,Line |
R2010 |
T3270 |
T3271 |
compound |
Sine,B1 |
R2011 |
T3271 |
T3267 |
conj |
B1,Line |
R2012 |
T3272 |
T3273 |
punct |
(,all |
R2013 |
T3273 |
T3266 |
parataxis |
all,families |
R2014 |
T3274 |
T3273 |
acl |
assayed,all |
R2015 |
T3275 |
T3274 |
prep |
with,assayed |
R2016 |
T3276 |
T3275 |
pobj |
HpaII,with |
R2017 |
T3277 |
T3273 |
punct |
),all |
R2018 |
T3278 |
T3224 |
punct |
.,include |
R2019 |
T3280 |
T3281 |
det |
These,repeats |
R2020 |
T3281 |
T3282 |
nsubjpass |
repeats,found |
R2021 |
T3283 |
T3282 |
auxpass |
were,found |
R2022 |
T3284 |
T3285 |
aux |
to,be |
R2023 |
T3285 |
T3282 |
xcomp |
be,found |
R2024 |
T3286 |
T3287 |
advmod |
moderately,methylated |
R2025 |
T3287 |
T3285 |
acomp |
methylated,be |
R2026 |
T3288 |
T3289 |
punct |
(,Line |
R2027 |
T3289 |
T3286 |
parataxis |
Line,moderately |
R2028 |
T3290 |
T3289 |
nummod |
1,Line |
R2029 |
T3291 |
T3289 |
cc |
and,Line |
R2030 |
T3292 |
T3293 |
compound |
Sine,B1 |
R2031 |
T3293 |
T3289 |
conj |
B1,Line |
R2032 |
T3294 |
T3289 |
punct |
),Line |
R2033 |
T3295 |
T3286 |
cc |
or,moderately |
R2034 |
T3296 |
T3286 |
conj |
highly,moderately |
R2035 |
T3297 |
T3298 |
punct |
(,IAP |
R2036 |
T3298 |
T3296 |
parataxis |
IAP,highly |
R2037 |
T3299 |
T3298 |
punct |
", ",IAP |
R2038 |
T3300 |
T3301 |
amod |
major,satellite |
R2039 |
T3301 |
T3298 |
appos |
satellite,IAP |
R2040 |
T3302 |
T3298 |
punct |
", ",IAP |
R2041 |
T3303 |
T3304 |
amod |
minor,satellite |
R2042 |
T3304 |
T3298 |
appos |
satellite,IAP |
R2043 |
T3305 |
T3298 |
punct |
),IAP |
R2044 |
T3306 |
T3285 |
prep |
in,be |
R2045 |
T3307 |
T3308 |
amod |
wild,type |
R2046 |
T3308 |
T3310 |
compound |
type,cells |
R2047 |
T3309 |
T3308 |
punct |
-,type |
R2048 |
T3310 |
T3306 |
pobj |
cells,in |
R2049 |
T3311 |
T3310 |
compound |
ES,cells |
R2050 |
T3312 |
T3282 |
punct |
", ",found |
R2051 |
T3313 |
T3282 |
cc |
and,found |
R2052 |
T3314 |
T3315 |
det |
this,methylation |
R2053 |
T3315 |
T3316 |
nsubjpass |
methylation,perturbed |
R2054 |
T3316 |
T3282 |
conj |
perturbed,found |
R2055 |
T3317 |
T3316 |
auxpass |
was,perturbed |
R2056 |
T3318 |
T3316 |
neg |
not,perturbed |
R2057 |
T3319 |
T3316 |
advmod |
detectably,perturbed |
R2058 |
T3320 |
T3316 |
agent |
by,perturbed |
R2059 |
T3321 |
T3322 |
det |
the,absence |
R2060 |
T3322 |
T3320 |
pobj |
absence,by |
R2061 |
T3323 |
T3322 |
prep |
of,absence |
R2062 |
T3324 |
T3323 |
pobj |
Atrx,of |
R2063 |
T3325 |
T3326 |
punct |
(,S3 |
R2064 |
T3326 |
T3316 |
parataxis |
S3,perturbed |
R2065 |
T3327 |
T3326 |
compound |
Figure,S3 |
R2066 |
T3328 |
T3326 |
cc |
and,S3 |
R2067 |
T3329 |
T3330 |
amod |
unpublished,data |
R2068 |
T3330 |
T3326 |
conj |
data,S3 |
R2069 |
T3331 |
T3326 |
punct |
),S3 |
R2070 |
T3332 |
T3316 |
punct |
.,perturbed |
R2071 |
T3334 |
T3335 |
advcl |
Taken,indicate |
R2072 |
T3336 |
T3334 |
advmod |
together,Taken |
R2073 |
T3337 |
T3335 |
punct |
", ",indicate |
R2074 |
T3338 |
T3339 |
det |
these,data |
R2075 |
T3339 |
T3335 |
nsubj |
data,indicate |
R2076 |
T3340 |
T3341 |
mark |
that,is |
R2077 |
T3341 |
T3335 |
ccomp |
is,indicate |
R2078 |
T3342 |
T3343 |
det |
the,interplay |
R2079 |
T3343 |
T3341 |
nsubj |
interplay,is |
R2080 |
T3344 |
T3343 |
amod |
subtle,interplay |
R2081 |
T3345 |
T3343 |
prep |
between,interplay |
R2082 |
T3346 |
T3347 |
det |
the,protein |
R2083 |
T3347 |
T3345 |
pobj |
protein,between |
R2084 |
T3348 |
T3347 |
compound |
ATRX,protein |
R2085 |
T3349 |
T3347 |
cc |
and,protein |
R2086 |
T3350 |
T3351 |
compound |
DNA,methylation |
R2087 |
T3351 |
T3347 |
conj |
methylation,protein |
R2088 |
T3352 |
T3343 |
acl |
observed,interplay |
R2089 |
T3353 |
T3352 |
prep |
in,observed |
R2090 |
T3354 |
T3355 |
amod |
human,patients |
R2091 |
T3355 |
T3353 |
pobj |
patients,in |
R2092 |
T3356 |
T3341 |
advmod |
also,is |
R2093 |
T3357 |
T3341 |
acomp |
present,is |
R2094 |
T3358 |
T3341 |
prep |
in,is |
R2095 |
T3359 |
T3360 |
compound |
mouse,cells |
R2096 |
T3360 |
T3358 |
pobj |
cells,in |
R2097 |
T3361 |
T3335 |
punct |
.,indicate |