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PMC:1435744 / 33207-34811 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T20442 40-46 SO_EXT:0000417 denotes domain
T20443 52-59 CHEBI_PR_EXT:protein denotes protein
T20444 60-67 CHEBI_PR_EXT:protein denotes protein
T20445 80-86 SO_EXT:0000417 denotes module
T20446 96-102 SO_EXT:0000417 denotes domain
T20447 110-114 PR_EXT:000014441 denotes mr-s
T20448 115-122 CHEBI_PR_EXT:protein denotes protein
T20449 160-163 PR_EXT:000007229 denotes TEL
T20450 175-182 SO_EXT:0000417 denotes domains
T20451 194-201 SO_EXT:0001114 denotes helical
T20452 216-225 CHEBI:33839 denotes polymeric
T20453 280-289 GO:0000785 denotes chromatin
T20454 321-332 CHEBI_EXT:biochemical denotes biochemical
T20455 345-349 PR_EXT:000014441 denotes mr-s
T20456 364-369 NCBITaxon_EXT:yeast denotes yeast
T20457 409-413 PR_EXT:000014441 denotes mr-s
T20458 467-473 SO_EXT:sequence_cloned_entity denotes clones
T20459 507-511 SO_EXT:cDNA denotes cDNA
T20460 541-547 SO_EXT:0000417 denotes domain
T20461 551-555 PR_EXT:000014441 denotes mr-s
T20462 585-589 PR_EXT:000014441 denotes mr-s
T20463 622-628 SO_EXT:0000417 denotes domain
T20464 675-683 GO_EXT:biological_direction_or_guidance denotes directed
T20465 684-691 SO_EXT:sequence_altered_entity denotes mutants
T20466 703-709 SO_EXT:0000417 denotes domain
T20467 713-717 PR_EXT:000014441 denotes mr-s
T20468 741-745 PR_EXT:000014441 denotes mr-s
T20469 746-753 CHEBI_PR_EXT:protein denotes protein
T20470 789-795 SO_EXT:0000417 denotes domain
T20471 799-808 NCBITaxon:40674 denotes mammalian
T20472 809-814 CL_GO_EXT:cell denotes cells
T20473 870-876 SO_EXT:0000417 denotes domain
T20474 880-884 PR_EXT:000014441 denotes mr-s
T20475 893-902 CHEBI:33839 denotes polymeric
T20476 968-974 SO_EXT:0000417 denotes domain
T20477 978-982 PR_EXT:000014441 denotes mr-s
T20478 997-1003 SO_EXT:0000417 denotes domain
T20479 1015-1024 CHEBI:36357 denotes molecules
T20480 1039-1043 PR_EXT:000014441 denotes mr-s
T20481 1066-1073 CHEBI:33839 denotes polymer
T20482 1086-1090 SO_EXT:0000704 denotes gene
T20483 1086-1100 GO:0016458 denotes gene silencing
T20484 1125-1134 GO:0032991 denotes complexes
T20485 1145-1154 GO:0000785 denotes chromatin
T20486 1176-1179 PR_EXT:000007229 denotes TEL
T20487 1257-1267 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T20488 1268-1278 SO_EXT:engineered_biological_sequence denotes constructs
T20489 1293-1299 SO_EXT:0000417 denotes domain
T20490 1379-1386 CHEBI:33839 denotes polymer
T20491 1447-1454 CHEBI_PR_EXT:protein denotes protein
T20492 1455-1462 CHEBI_PR_EXT:protein denotes protein
T20493 1478-1482 PR_EXT:000014441 denotes mr-s
T20494 1509-1519 GO:0010467 denotes expression
T20495 1560-1564 PR_EXT:000014441 denotes mr-s
T20496 1573-1580 CHEBI:33839 denotes polymer

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T20202 40-46 SO:0000417 denotes domain
T20203 80-86 SO:0000417 denotes module
T20204 96-102 SO:0000417 denotes domain
T20205 110-114 PR:000014441 denotes mr-s
T20206 160-163 PR:000007229 denotes TEL
T20207 175-182 SO:0000417 denotes domains
T20208 194-201 SO:0001114 denotes helical
T20209 216-225 CHEBI:33839 denotes polymeric
T20210 280-289 GO:0000785 denotes chromatin
T20211 345-349 PR:000014441 denotes mr-s
T20212 409-413 PR:000014441 denotes mr-s
T20213 541-547 SO:0000417 denotes domain
T20214 551-555 PR:000014441 denotes mr-s
T20215 585-589 PR:000014441 denotes mr-s
T20216 622-628 SO:0000417 denotes domain
T20217 703-709 SO:0000417 denotes domain
T20218 713-717 PR:000014441 denotes mr-s
T20219 741-745 PR:000014441 denotes mr-s
T20220 789-795 SO:0000417 denotes domain
T20221 799-808 NCBITaxon:40674 denotes mammalian
T20222 870-876 SO:0000417 denotes domain
T20223 880-884 PR:000014441 denotes mr-s
T20224 893-902 CHEBI:33839 denotes polymeric
T20225 968-974 SO:0000417 denotes domain
T20226 978-982 PR:000014441 denotes mr-s
T20227 997-1003 SO:0000417 denotes domain
T20228 1015-1024 CHEBI:36357 denotes molecules
T20229 1039-1043 PR:000014441 denotes mr-s
T20230 1066-1073 CHEBI:33839 denotes polymer
T20231 1086-1090 SO:0000704 denotes gene
T20232 1086-1100 GO:0016458 denotes gene silencing
T20233 1125-1134 GO:0032991 denotes complexes
T20234 1145-1154 GO:0000785 denotes chromatin
T20235 1176-1179 PR:000007229 denotes TEL
T20236 1293-1299 SO:0000417 denotes domain
T20237 1379-1386 CHEBI:33839 denotes polymer
T20238 1478-1482 PR:000014441 denotes mr-s
T20239 1509-1519 GO:0010467 denotes expression
T20240 1560-1564 PR:000014441 denotes mr-s
T20241 1573-1580 CHEBI:33839 denotes polymer

craft-sa-dev

Id Subject Object Predicate Lexical cue
T21040 0-8 JJ denotes Previous
T21041 9-16 NNS denotes reports
T21042 17-26 VBD denotes suggested
T21043 27-31 IN denotes that
T21044 47-49 VBZ denotes is
T21045 32-35 DT denotes the
T21046 40-46 NN denotes domain
T21047 36-39 NN denotes SAM
T21048 50-51 DT denotes a
T21049 80-86 NN denotes module
T21050 52-59 NN denotes protein
T21051 60-67 NN denotes protein
T21052 59-60 HYPH denotes -
T21053 68-79 NN denotes interaction
T21054 86-87 . denotes .
T21055 87-300 sentence denotes The SAM domain of the mr-s protein is closely related to that of ph and TEL, whose SAM domains can form a helical, head-to-tail polymeric structure and mediate the formation of a higher order chromatin structure.
T21056 88-91 DT denotes The
T21057 96-102 NN denotes domain
T21058 92-95 NN denotes SAM
T21059 134-141 VBN denotes related
T21060 103-105 IN denotes of
T21061 106-109 DT denotes the
T21062 115-122 NN denotes protein
T21063 110-112 NN denotes mr
T21064 113-114 NN denotes s
T21065 112-113 HYPH denotes -
T21066 123-125 VBZ denotes is
T21067 126-133 RB denotes closely
T21068 142-144 IN denotes to
T21069 145-149 DT denotes that
T21070 150-152 IN denotes of
T21071 153-155 NN denotes ph
T21072 156-159 CC denotes and
T21073 160-163 NN denotes TEL
T21074 163-165 , denotes ,
T21075 165-170 WP$ denotes whose
T21076 175-182 NNS denotes domains
T21077 171-174 NN denotes SAM
T21078 187-191 VB denotes form
T21079 183-186 MD denotes can
T21080 192-193 DT denotes a
T21081 226-235 NN denotes structure
T21082 194-201 JJ denotes helical
T21083 201-203 , denotes ,
T21084 203-207 NN denotes head
T21085 207-208 HYPH denotes -
T21086 208-210 IN denotes to
T21087 210-211 HYPH denotes -
T21088 211-215 NN denotes tail
T21089 216-225 JJ denotes polymeric
T21090 236-239 CC denotes and
T21091 240-247 VB denotes mediate
T21092 248-251 DT denotes the
T21093 252-261 NN denotes formation
T21094 262-264 IN denotes of
T21095 265-266 DT denotes a
T21096 290-299 NN denotes structure
T21097 267-273 JJR denotes higher
T21098 274-279 NN denotes order
T21099 280-289 NN denotes chromatin
T21100 299-300 . denotes .
T21101 300-426 sentence denotes To characterize the biochemical function of mr-s, we performed yeast two-hybrid screening using full-length mr-s as the bait.
T21102 301-303 TO denotes To
T21103 304-316 VB denotes characterize
T21104 354-363 VBD denotes performed
T21105 317-320 DT denotes the
T21106 333-341 NN denotes function
T21107 321-332 JJ denotes biochemical
T21108 342-344 IN denotes of
T21109 345-347 NN denotes mr
T21110 348-349 NN denotes s
T21111 347-348 HYPH denotes -
T21112 349-351 , denotes ,
T21113 351-353 PRP denotes we
T21114 364-369 NN denotes yeast
T21115 381-390 NN denotes screening
T21116 370-373 CD denotes two
T21117 374-380 NN denotes hybrid
T21118 373-374 HYPH denotes -
T21119 391-396 VBG denotes using
T21120 397-401 JJ denotes full
T21121 402-408 NN denotes length
T21122 401-402 HYPH denotes -
T21123 412-413 NN denotes s
T21124 409-411 NN denotes mr
T21125 411-412 HYPH denotes -
T21126 414-416 IN denotes as
T21127 417-420 DT denotes the
T21128 421-425 NN denotes bait
T21129 425-426 . denotes .
T21130 426-556 sentence denotes As a result, the most frequent positive clones (5/28) in the screening were the cDNA fragments containing the SAM domain of mr-s.
T21131 427-429 IN denotes As
T21132 498-502 VBD denotes were
T21133 430-431 DT denotes a
T21134 432-438 NN denotes result
T21135 438-440 , denotes ,
T21136 440-443 DT denotes the
T21137 467-473 NNS denotes clones
T21138 444-448 RBS denotes most
T21139 449-457 JJ denotes frequent
T21140 458-466 JJ denotes positive
T21141 474-475 -LRB- denotes (
T21142 475-476 CD denotes 5
T21143 476-477 SYM denotes /
T21144 477-479 CD denotes 28
T21145 479-480 -RRB- denotes )
T21146 481-483 IN denotes in
T21147 484-487 DT denotes the
T21148 488-497 NN denotes screening
T21149 503-506 DT denotes the
T21150 512-521 NNS denotes fragments
T21151 507-511 NN denotes cDNA
T21152 522-532 VBG denotes containing
T21153 533-536 DT denotes the
T21154 541-547 NN denotes domain
T21155 537-540 NN denotes SAM
T21156 548-550 IN denotes of
T21157 551-553 NN denotes mr
T21158 554-555 NN denotes s
T21159 553-554 HYPH denotes -
T21160 555-556 . denotes .
T21161 556-629 sentence denotes This strongly suggests that mr-s self-associates through its SAM domain.
T21162 557-561 DT denotes This
T21163 571-579 VBZ denotes suggests
T21164 562-570 RB denotes strongly
T21165 580-584 IN denotes that
T21166 595-605 VBZ denotes associates
T21167 585-587 NN denotes mr
T21168 588-589 NN denotes s
T21169 587-588 HYPH denotes -
T21170 590-594 NN denotes self
T21171 594-595 HYPH denotes -
T21172 606-613 IN denotes through
T21173 614-617 PRP$ denotes its
T21174 622-628 NN denotes domain
T21175 618-621 NN denotes SAM
T21176 628-629 . denotes .
T21177 629-815 sentence denotes An immunoprecipitation assay, using two site-directed mutants of the SAM domain of mr-s, demonstrated that the mr-s protein can self-associate through its SAM domain in mammalian cells.
T21178 630-632 DT denotes An
T21179 653-658 NN denotes assay
T21180 633-652 NN denotes immunoprecipitation
T21181 719-731 VBD denotes demonstrated
T21182 658-660 , denotes ,
T21183 660-665 VBG denotes using
T21184 666-669 CD denotes two
T21185 684-691 NNS denotes mutants
T21186 670-674 NN denotes site
T21187 675-683 VBN denotes directed
T21188 674-675 HYPH denotes -
T21189 692-694 IN denotes of
T21190 695-698 DT denotes the
T21191 703-709 NN denotes domain
T21192 699-702 NN denotes SAM
T21193 710-712 IN denotes of
T21194 713-715 NN denotes mr
T21195 716-717 NN denotes s
T21196 715-716 HYPH denotes -
T21197 717-719 , denotes ,
T21198 732-736 IN denotes that
T21199 763-772 VB denotes associate
T21200 737-740 DT denotes the
T21201 746-753 NN denotes protein
T21202 741-743 NN denotes mr
T21203 744-745 NN denotes s
T21204 743-744 HYPH denotes -
T21205 754-757 MD denotes can
T21206 758-762 NN denotes self
T21207 762-763 HYPH denotes -
T21208 773-780 IN denotes through
T21209 781-784 PRP$ denotes its
T21210 789-795 NN denotes domain
T21211 785-788 NN denotes SAM
T21212 796-798 IN denotes in
T21213 799-808 JJ denotes mammalian
T21214 809-814 NNS denotes cells
T21215 814-815 . denotes .
T21216 815-1180 sentence denotes While we did not address the question whether the SAM domain of mr-s forms a polymeric structure in the present study, the phylogenetic analysis of SAM domain of mr-s and other SAM domain-containing molecules suggests that mr-s can form head-to-tail polymer and mediate gene silencing by spreading repressive complexes along the chromatin similar to ph and/or TEL.
T21217 816-821 IN denotes While
T21218 833-840 VB denotes address
T21219 822-824 PRP denotes we
T21220 825-828 VBD denotes did
T21221 829-832 RB denotes not
T21222 1025-1033 VBZ denotes suggests
T21223 841-844 DT denotes the
T21224 845-853 NN denotes question
T21225 854-861 IN denotes whether
T21226 885-890 VBZ denotes forms
T21227 862-865 DT denotes the
T21228 870-876 NN denotes domain
T21229 866-869 NN denotes SAM
T21230 877-879 IN denotes of
T21231 880-882 NN denotes mr
T21232 883-884 NN denotes s
T21233 882-883 HYPH denotes -
T21234 891-892 DT denotes a
T21235 903-912 NN denotes structure
T21236 893-902 JJ denotes polymeric
T21237 913-915 IN denotes in
T21238 916-919 DT denotes the
T21239 928-933 NN denotes study
T21240 920-927 JJ denotes present
T21241 933-935 , denotes ,
T21242 935-938 DT denotes the
T21243 952-960 NN denotes analysis
T21244 939-951 JJ denotes phylogenetic
T21245 961-963 IN denotes of
T21246 964-967 NN denotes SAM
T21247 968-974 NN denotes domain
T21248 975-977 IN denotes of
T21249 978-980 NN denotes mr
T21250 981-982 NN denotes s
T21251 980-981 HYPH denotes -
T21252 983-986 CC denotes and
T21253 987-992 JJ denotes other
T21254 1015-1024 NNS denotes molecules
T21255 993-996 NN denotes SAM
T21256 997-1003 NN denotes domain
T21257 1004-1014 VBG denotes containing
T21258 1003-1004 HYPH denotes -
T21259 1034-1038 IN denotes that
T21260 1048-1052 VB denotes form
T21261 1039-1041 NN denotes mr
T21262 1042-1043 NN denotes s
T21263 1041-1042 HYPH denotes -
T21264 1044-1047 MD denotes can
T21265 1053-1057 NN denotes head
T21266 1066-1073 NN denotes polymer
T21267 1057-1058 HYPH denotes -
T21268 1058-1060 IN denotes to
T21269 1060-1061 HYPH denotes -
T21270 1061-1065 NN denotes tail
T21271 1074-1077 CC denotes and
T21272 1078-1085 VBP denotes mediate
T21273 1086-1090 NN denotes gene
T21274 1091-1100 NN denotes silencing
T21275 1101-1103 IN denotes by
T21276 1104-1113 VBG denotes spreading
T21277 1114-1124 JJ denotes repressive
T21278 1125-1134 NNS denotes complexes
T21279 1135-1140 IN denotes along
T21280 1141-1144 DT denotes the
T21281 1145-1154 NN denotes chromatin
T21282 1155-1162 JJ denotes similar
T21283 1163-1165 IN denotes to
T21284 1166-1168 NN denotes ph
T21285 1169-1172 CC denotes and
T21286 1172-1173 HYPH denotes /
T21287 1173-1175 CC denotes or
T21288 1176-1179 NN denotes TEL
T21289 1179-1180 . denotes .
T21290 1180-1393 sentence denotes Although our results in the immunoprecipitation assay demonstrated that the N-terminal constructs lacking a SAM domain still interact with each other, these results do not fit into the head-to-tail polymer model.
T21291 1181-1189 IN denotes Although
T21292 1235-1247 VBD denotes demonstrated
T21293 1190-1193 PRP$ denotes our
T21294 1194-1201 NNS denotes results
T21295 1202-1204 IN denotes in
T21296 1205-1208 DT denotes the
T21297 1229-1234 NN denotes assay
T21298 1209-1228 NN denotes immunoprecipitation
T21299 1353-1356 VB denotes fit
T21300 1248-1252 IN denotes that
T21301 1306-1314 VBP denotes interact
T21302 1253-1256 DT denotes the
T21303 1268-1278 NNS denotes constructs
T21304 1257-1258 NN denotes N
T21305 1259-1267 JJ denotes terminal
T21306 1258-1259 HYPH denotes -
T21307 1279-1286 VBG denotes lacking
T21308 1287-1288 DT denotes a
T21309 1293-1299 NN denotes domain
T21310 1289-1292 NN denotes SAM
T21311 1300-1305 RB denotes still
T21312 1315-1319 IN denotes with
T21313 1320-1324 DT denotes each
T21314 1325-1330 JJ denotes other
T21315 1330-1332 , denotes ,
T21316 1332-1337 DT denotes these
T21317 1338-1345 NNS denotes results
T21318 1346-1348 VBP denotes do
T21319 1349-1352 RB denotes not
T21320 1357-1361 IN denotes into
T21321 1362-1365 DT denotes the
T21322 1387-1392 NN denotes model
T21323 1366-1370 NN denotes head
T21324 1370-1371 HYPH denotes -
T21325 1371-1373 IN denotes to
T21326 1373-1374 HYPH denotes -
T21327 1374-1378 NN denotes tail
T21328 1379-1386 NN denotes polymer
T21329 1392-1393 . denotes .
T21330 1393-1531 sentence denotes We cannot exclude the possibility that the resulting protein-protein interaction of mr-s is an artifact of the overexpression conditions.
T21331 1394-1396 PRP denotes We
T21332 1404-1411 VB denotes exclude
T21333 1397-1400 MD denotes can
T21334 1400-1403 RB denotes not
T21335 1412-1415 DT denotes the
T21336 1416-1427 NN denotes possibility
T21337 1428-1432 IN denotes that
T21338 1483-1485 VBZ denotes is
T21339 1433-1436 DT denotes the
T21340 1463-1474 NN denotes interaction
T21341 1437-1446 VBG denotes resulting
T21342 1447-1454 NN denotes protein
T21343 1455-1462 NN denotes protein
T21344 1454-1455 HYPH denotes -
T21345 1475-1477 IN denotes of
T21346 1478-1480 NN denotes mr
T21347 1481-1482 NN denotes s
T21348 1480-1481 HYPH denotes -
T21349 1486-1488 DT denotes an
T21350 1489-1497 NN denotes artifact
T21351 1498-1500 IN denotes of
T21352 1501-1504 DT denotes the
T21353 1520-1530 NNS denotes conditions
T21354 1505-1519 NN denotes overexpression
T21355 1530-1531 . denotes .
T21356 1531-1604 sentence denotes The issue of whether or not mr-s forms a polymer awaits future analysis.
T21357 1532-1535 DT denotes The
T21358 1536-1541 NN denotes issue
T21359 1581-1587 VBZ denotes awaits
T21360 1542-1544 IN denotes of
T21361 1545-1552 IN denotes whether
T21362 1565-1570 VBZ denotes forms
T21363 1553-1555 CC denotes or
T21364 1556-1559 RB denotes not
T21365 1560-1562 NN denotes mr
T21366 1563-1564 NN denotes s
T21367 1562-1563 HYPH denotes -
T21368 1571-1572 DT denotes a
T21369 1573-1580 NN denotes polymer
T21370 1588-1594 JJ denotes future
T21371 1595-1603 NN denotes analysis
T21372 1603-1604 . denotes .
R5194 T21040 T21041 amod Previous,reports
R5195 T21041 T21042 nsubj reports,suggested
R5196 T21043 T21044 mark that,is
R5197 T21044 T21042 ccomp is,suggested
R5198 T21045 T21046 det the,domain
R5199 T21046 T21044 nsubj domain,is
R5200 T21047 T21046 compound SAM,domain
R5201 T21048 T21049 det a,module
R5202 T21049 T21044 attr module,is
R5203 T21050 T21051 compound protein,protein
R5204 T21051 T21049 compound protein,module
R5205 T21052 T21051 punct -,protein
R5206 T21053 T21049 compound interaction,module
R5207 T21054 T21042 punct .,suggested
R5208 T21056 T21057 det The,domain
R5209 T21057 T21059 nsubjpass domain,related
R5210 T21058 T21057 compound SAM,domain
R5211 T21060 T21057 prep of,domain
R5212 T21061 T21062 det the,protein
R5213 T21062 T21060 pobj protein,of
R5214 T21063 T21064 compound mr,s
R5215 T21064 T21062 compound s,protein
R5216 T21065 T21064 punct -,s
R5217 T21066 T21059 auxpass is,related
R5218 T21067 T21059 advmod closely,related
R5219 T21068 T21059 prep to,related
R5220 T21069 T21068 pobj that,to
R5221 T21070 T21069 prep of,that
R5222 T21071 T21070 pobj ph,of
R5223 T21072 T21071 cc and,ph
R5224 T21073 T21071 conj TEL,ph
R5225 T21074 T21071 punct ", ",ph
R5226 T21075 T21076 poss whose,domains
R5227 T21076 T21078 dep domains,form
R5228 T21077 T21076 compound SAM,domains
R5229 T21078 T21071 relcl form,ph
R5230 T21079 T21078 aux can,form
R5231 T21080 T21081 det a,structure
R5232 T21081 T21078 dobj structure,form
R5233 T21082 T21081 amod helical,structure
R5234 T21083 T21081 punct ", ",structure
R5235 T21084 T21081 nmod head,structure
R5236 T21085 T21084 punct -,head
R5237 T21086 T21084 prep to,head
R5238 T21087 T21086 punct -,to
R5239 T21088 T21086 pobj tail,to
R5240 T21089 T21081 amod polymeric,structure
R5241 T21090 T21078 cc and,form
R5242 T21091 T21078 conj mediate,form
R5243 T21092 T21093 det the,formation
R5244 T21093 T21091 dobj formation,mediate
R5245 T21094 T21093 prep of,formation
R5246 T21095 T21096 det a,structure
R5247 T21096 T21094 pobj structure,of
R5248 T21097 T21098 amod higher,order
R5249 T21098 T21096 compound order,structure
R5250 T21099 T21096 compound chromatin,structure
R5251 T21100 T21059 punct .,related
R5252 T21102 T21103 aux To,characterize
R5253 T21103 T21104 advcl characterize,performed
R5254 T21105 T21106 det the,function
R5255 T21106 T21103 dobj function,characterize
R5256 T21107 T21106 amod biochemical,function
R5257 T21108 T21106 prep of,function
R5258 T21109 T21110 compound mr,s
R5259 T21110 T21108 pobj s,of
R5260 T21111 T21110 punct -,s
R5261 T21112 T21104 punct ", ",performed
R5262 T21113 T21104 nsubj we,performed
R5263 T21114 T21115 nmod yeast,screening
R5264 T21115 T21104 dobj screening,performed
R5265 T21116 T21117 nummod two,hybrid
R5266 T21117 T21115 compound hybrid,screening
R5267 T21118 T21117 punct -,hybrid
R5268 T21119 T21104 advcl using,performed
R5269 T21120 T21121 amod full,length
R5270 T21121 T21123 compound length,s
R5271 T21122 T21121 punct -,length
R5272 T21123 T21119 dobj s,using
R5273 T21124 T21123 compound mr,s
R5274 T21125 T21123 punct -,s
R5275 T21126 T21119 prep as,using
R5276 T21127 T21128 det the,bait
R5277 T21128 T21126 pobj bait,as
R5278 T21129 T21104 punct .,performed
R5279 T21131 T21132 prep As,were
R5280 T21133 T21134 det a,result
R5281 T21134 T21131 pobj result,As
R5282 T21135 T21132 punct ", ",were
R5283 T21136 T21137 det the,clones
R5284 T21137 T21132 nsubj clones,were
R5285 T21138 T21139 advmod most,frequent
R5286 T21139 T21137 amod frequent,clones
R5287 T21140 T21137 amod positive,clones
R5288 T21141 T21142 punct (,5
R5289 T21142 T21137 parataxis 5,clones
R5290 T21143 T21144 punct /,28
R5291 T21144 T21142 prep 28,5
R5292 T21145 T21142 punct ),5
R5293 T21146 T21137 prep in,clones
R5294 T21147 T21148 det the,screening
R5295 T21148 T21146 pobj screening,in
R5296 T21173 T21174 poss its,domain
R5297 T21149 T21150 det the,fragments
R5298 T21174 T21172 pobj domain,through
R5299 T21150 T21132 attr fragments,were
R5300 T21175 T21174 compound SAM,domain
R5301 T21176 T21163 punct .,suggests
R5302 T21151 T21150 compound cDNA,fragments
R5303 T21178 T21179 det An,assay
R5304 T21152 T21150 acl containing,fragments
R5305 T21179 T21181 nsubj assay,demonstrated
R5306 T21180 T21179 compound immunoprecipitation,assay
R5307 T21153 T21154 det the,domain
R5308 T21182 T21179 punct ", ",assay
R5309 T21154 T21152 dobj domain,containing
R5310 T21183 T21179 acl using,assay
R5311 T21184 T21185 nummod two,mutants
R5312 T21185 T21183 dobj mutants,using
R5313 T21155 T21154 compound SAM,domain
R5314 T21186 T21187 npadvmod site,directed
R5315 T21187 T21185 amod directed,mutants
R5316 T21188 T21187 punct -,directed
R5317 T21156 T21154 prep of,domain
R5318 T21189 T21185 prep of,mutants
R5319 T21190 T21191 det the,domain
R5320 T21157 T21158 compound mr,s
R5321 T21191 T21189 pobj domain,of
R5322 T21192 T21191 compound SAM,domain
R5323 T21193 T21191 prep of,domain
R5324 T21158 T21156 pobj s,of
R5325 T21194 T21195 compound mr,s
R5326 T21195 T21193 pobj s,of
R5327 T21159 T21158 punct -,s
R5328 T21196 T21195 punct -,s
R5329 T21160 T21132 punct .,were
R5330 T21162 T21163 nsubj This,suggests
R5331 T21197 T21181 punct ", ",demonstrated
R5332 T21198 T21199 mark that,associate
R5333 T21164 T21163 advmod strongly,suggests
R5334 T21199 T21181 ccomp associate,demonstrated
R5335 T21200 T21201 det the,protein
R5336 T21201 T21199 nsubj protein,associate
R5337 T21202 T21203 compound mr,s
R5338 T21203 T21201 compound s,protein
R5339 T21165 T21166 mark that,associates
R5340 T21204 T21203 punct -,s
R5341 T21166 T21163 ccomp associates,suggests
R5342 T21205 T21199 aux can,associate
R5343 T21206 T21199 dep self,associate
R5344 T21207 T21199 punct -,associate
R5345 T21208 T21199 prep through,associate
R5346 T21209 T21210 poss its,domain
R5347 T21167 T21168 compound mr,s
R5348 T21210 T21208 pobj domain,through
R5349 T21211 T21210 compound SAM,domain
R5350 T21168 T21166 nsubj s,associates
R5351 T21212 T21199 prep in,associate
R5352 T21213 T21214 amod mammalian,cells
R5353 T21214 T21212 pobj cells,in
R5354 T21169 T21168 punct -,s
R5355 T21215 T21181 punct .,demonstrated
R5356 T21170 T21166 dep self,associates
R5357 T21217 T21218 mark While,address
R5358 T21218 T21222 advcl address,suggests
R5359 T21171 T21166 punct -,associates
R5360 T21219 T21218 nsubj we,address
R5361 T21220 T21218 aux did,address
R5362 T21221 T21218 neg not,address
R5363 T21172 T21166 prep through,associates
R5364 T21223 T21224 det the,question
R5365 T21224 T21218 dobj question,address
R5366 T21279 T21276 prep along,spreading
R5367 T21225 T21226 mark whether,forms
R5368 T21226 T21224 acl forms,question
R5369 T21227 T21228 det the,domain
R5370 T21228 T21226 nsubj domain,forms
R5371 T21280 T21281 det the,chromatin
R5372 T21229 T21228 compound SAM,domain
R5373 T21230 T21228 prep of,domain
R5374 T21281 T21279 pobj chromatin,along
R5375 T21231 T21232 compound mr,s
R5376 T21232 T21230 pobj s,of
R5377 T21233 T21232 punct -,s
R5378 T21282 T21272 advcl similar,mediate
R5379 T21234 T21235 det a,structure
R5380 T21235 T21226 dobj structure,forms
R5381 T21283 T21282 prep to,similar
R5382 T21236 T21235 amod polymeric,structure
R5383 T21237 T21218 prep in,address
R5384 T21238 T21239 det the,study
R5385 T21284 T21283 pobj ph,to
R5386 T21239 T21237 pobj study,in
R5387 T21240 T21239 amod present,study
R5388 T21241 T21222 punct ", ",suggests
R5389 T21242 T21243 det the,analysis
R5390 T21243 T21222 nsubj analysis,suggests
R5391 T21244 T21243 amod phylogenetic,analysis
R5392 T21285 T21284 cc and,ph
R5393 T21245 T21243 prep of,analysis
R5394 T21286 T21285 punct /,and
R5395 T21246 T21247 compound SAM,domain
R5396 T21247 T21245 pobj domain,of
R5397 T21248 T21247 prep of,domain
R5398 T21249 T21250 compound mr,s
R5399 T21287 T21285 cc or,and
R5400 T21250 T21248 pobj s,of
R5401 T21251 T21250 punct -,s
R5402 T21252 T21250 cc and,s
R5403 T21288 T21284 conj TEL,ph
R5404 T21253 T21254 amod other,molecules
R5405 T21254 T21250 conj molecules,s
R5406 T21289 T21222 punct .,suggests
R5407 T21255 T21256 compound SAM,domain
R5408 T21256 T21257 npadvmod domain,containing
R5409 T21257 T21254 amod containing,molecules
R5410 T21291 T21292 mark Although,demonstrated
R5411 T21258 T21257 punct -,containing
R5412 T21259 T21260 mark that,form
R5413 T21260 T21222 ccomp form,suggests
R5414 T21261 T21262 compound mr,s
R5415 T21292 T21299 advcl demonstrated,fit
R5416 T21262 T21260 nsubj s,form
R5417 T21263 T21262 punct -,s
R5418 T21293 T21294 poss our,results
R5419 T21264 T21260 aux can,form
R5420 T21265 T21266 nmod head,polymer
R5421 T21266 T21260 dobj polymer,form
R5422 T21294 T21292 nsubj results,demonstrated
R5423 T21267 T21265 punct -,head
R5424 T21268 T21265 prep to,head
R5425 T21295 T21294 prep in,results
R5426 T21269 T21268 punct -,to
R5427 T21270 T21268 pobj tail,to
R5428 T21271 T21260 cc and,form
R5429 T21296 T21297 det the,assay
R5430 T21272 T21260 conj mediate,form
R5431 T21273 T21274 compound gene,silencing
R5432 T21274 T21272 dobj silencing,mediate
R5433 T21297 T21295 pobj assay,in
R5434 T21275 T21272 prep by,mediate
R5435 T21276 T21275 pcomp spreading,by
R5436 T21298 T21297 compound immunoprecipitation,assay
R5437 T21277 T21278 amod repressive,complexes
R5438 T21278 T21276 dobj complexes,spreading
R5439 T21300 T21301 mark that,interact
R5440 T21301 T21292 ccomp interact,demonstrated
R5442 T21302 T21303 det the,constructs
R5445 T21303 T21301 nsubj constructs,interact
R5448 T21304 T21305 npadvmod N,terminal
R5451 T21305 T21303 amod terminal,constructs
R5455 T21306 T21305 punct -,terminal
R5458 T21307 T21303 acl lacking,constructs
R5462 T21308 T21309 det a,domain
R5466 T21309 T21307 dobj domain,lacking
R5469 T21310 T21309 compound SAM,domain
R5472 T21311 T21301 advmod still,interact
R5474 T21312 T21301 prep with,interact
R5478 T21313 T21314 det each,other
R5481 T21314 T21312 pobj other,with
R5485 T21315 T21299 punct ", ",fit
R5489 T21316 T21317 det these,results
R5491 T21317 T21299 nsubj results,fit
R5493 T21318 T21299 aux do,fit
R5496 T21319 T21299 neg not,fit
R5498 T21320 T21299 prep into,fit
R5501 T21321 T21322 det the,model
R5505 T21322 T21320 pobj model,into
R5508 T21323 T21322 nmod head,model
R5512 T21324 T21323 punct -,head
R5516 T21325 T21323 prep to,head
R5520 T21326 T21325 punct -,to
R5524 T21327 T21325 pobj tail,to
R5527 T21328 T21322 compound polymer,model
R5530 T21329 T21299 punct .,fit
R5533 T21331 T21332 nsubj We,exclude
R5534 T21333 T21332 aux can,exclude
R5536 T21334 T21332 neg not,exclude
R5540 T21335 T21336 det the,possibility
R5544 T21336 T21332 dobj possibility,exclude
R5549 T21337 T21338 mark that,is
R5553 T21338 T21336 acl is,possibility
R5556 T21339 T21340 det the,interaction
R5559 T21340 T21338 nsubj interaction,is
R5563 T21341 T21340 amod resulting,interaction
R5566 T21342 T21343 compound protein,protein
R5570 T21343 T21340 compound protein,interaction
R5573 T21344 T21343 punct -,protein
R5577 T21345 T21340 prep of,interaction
R5580 T21346 T21347 compound mr,s
R5581 T21347 T21345 pobj s,of
R5582 T21348 T21347 punct -,s
R5583 T21349 T21350 det an,artifact
R5584 T21350 T21338 attr artifact,is
R5588 T21351 T21350 prep of,artifact
R5592 T21352 T21353 det the,conditions
R5596 T21353 T21351 pobj conditions,of
R5603 T21354 T21353 compound overexpression,conditions
R5606 T21355 T21332 punct .,exclude
R5609 T21357 T21358 det The,issue
R5614 T21358 T21359 nsubj issue,awaits
R5617 T21360 T21358 prep of,issue
R5621 T21361 T21362 mark whether,forms
R5625 T21362 T21360 pcomp forms,of
R5629 T21363 T21362 cc or,forms
R5633 T21364 T21362 neg not,forms
R5637 T21365 T21366 compound mr,s
R5641 T21366 T21362 nsubj s,forms
R5645 T21367 T21366 punct -,s
R5648 T21368 T21369 det a,polymer
R5650 T21369 T21362 dobj polymer,forms
R5654 T21370 T21371 amod future,analysis
R5658 T21371 T21359 dobj analysis,awaits
R5661 T21372 T21359 punct .,awaits