PMC:1420314 / 8729-10244 JSONTXT

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In the rotating rod test, the retention time of (+/-) and (-/-) mice on the rod was not significantly different from that of (+/+) mice at 0 rpm (stationary) [+/-: F (1, 80) = 1.67, p = 0.21; -/-: F (1, 88) = 0.002, p = 0.96] (Fig. 3A). In (+/-) mice, the tendency of decreased retention times was seen at 5, 10 and 15 rpm, but there was no significant difference between (+/+) and (+/-) mice [5 rpm: F (1, 20) = 1.27, p = 0.27; 10 rpm: F (1, 20) = 1.07, p = 0.31; 15 rpm: F (1, 20) = 2.716, p = 0.11] (Figs. 3B, 3C and 3D). However, (-/-) mice fell more quickly from the rod than (+/+) mice at 5, 10 and 15 rpm [5 rpm: F (1, 27.3) = 17.51, p = 0.0002; 10 rpm: F (1, 22) = 11.05, p = 0.003; 15 rpm: F (1, 22) = 19.22, p = 0.0002] (Figs. 3B, 3C and 3D). The retention time was not significantly improved in (-/-) mice across trials of training at 5, 10 and 15 rpm [5 rpm: F (3, 15.3) = 2.05, p = 0.15; 10 rpm: F (7, 11) = 2.61, p = 0.07; 15 rpm: F (19, 26.6) = 1.57, p = 0.14] (Figs. 3B, 3C and 3D). In a traction test, (-/-) mice showed a high grip strength similar to that of (+/+) and (+/-) mice (Fig. 4). The hanging score and time of (-/-) mice were also similar to those of (+/+) and (+/-) mice (Figs. 5A and 5B). A footprint test did not reveal any abnormalities in walking patterns, including stride length and step width, as a function of genotypes (Figs. 6A and 6B)."}

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study the functions of ADAM11 in the cerebellum, we examined the motor function of ADAM11-deficient mice using a rotating rod task [28]. In the rotating rod test, the retention time of (+/-) and (-/-) mice on the rod was not significantly different from that of (+/+) mice at 0 rpm (stationary) [+/-: F (1, 80) = 1.67, p = 0.21; -/-: F (1, 88) = 0.002, p = 0.96] (Fig. 3A). In (+/-) mice, the tendency of decreased retention times was seen at 5, 10 and 15 rpm, but there was no significant difference between (+/+) and (+/-) mice [5 rpm: F (1, 20) = 1.27, p = 0.27; 10 rpm: F (1, 20) = 1.07, p = 0.31; 15 rpm: F (1, 20) = 2.716, p = 0.11] (Figs. 3B, 3C and 3D). However, (-/-) mice fell more quickly from the rod than (+/+) mice at 5, 10 and 15 rpm [5 rpm: F (1, 27.3) = 17.51, p = 0.0002; 10 rpm: F (1, 22) = 11.05, p = 0.003; 15 rpm: F (1, 22) = 19.22, p = 0.0002] (Figs. 3B, 3C and 3D). The retention time was not significantly improved in (-/-) mice across trials of training at 5, 10 and 15 rpm [5 rpm: F (3, 15.3) = 2.05, p = 0.15; 10 rpm: F (7, 11) = 2.61, p = 0.07; 15 rpm: F (19, 26.6) = 1.57, p = 0.14] (Figs. 3B, 3C and 3D). In a traction test, (-/-) mice showed a high grip strength similar to that of (+/+) and (+/-) mice (Fig. 4). The hanging score and time of (-/-) mice were also similar to those of (+/+) and (+/-) mice (Figs. 5A and 5B). A footprint test did not reveal any abnormalities in walking patterns, including stride length and step width, as a function of genotypes (Figs. 6A and 6B)."}