PMC:1420314 / 1389-1719
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1420314","sourcedb":"PMC","sourceid":"1420314","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1420314","text":"se) family comprises membrane-spanning multi-domain proteins containing a metalloproteinase-like domain and a disintegrin-like domain. Approximately half of the ADAMs are catalytically active metalloproteases that shed a broad range of substrates, such as cytokines, growth factors, receptors, adhesion molecules [1,2]. Recent gen","tracks":[{"project":"craft-ca-core-dev","denotations":[{"id":"T1984","span":{"begin":21,"end":29},"obj":"GO:0016020"},{"id":"T1985","span":{"begin":45,"end":51},"obj":"SO:0000417"},{"id":"T1986","span":{"begin":97,"end":103},"obj":"SO:0000417"},{"id":"T1987","span":{"begin":127,"end":133},"obj":"SO:0000417"},{"id":"T1988","span":{"begin":303,"end":312},"obj":"CHEBI:36357"}],"attributes":[{"subj":"T1984","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T1985","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T1986","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T1987","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T1988","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2070","span":{"begin":21,"end":29},"obj":"GO:0016020"},{"id":"T2071","span":{"begin":45,"end":51},"obj":"SO_EXT:0000417"},{"id":"T2072","span":{"begin":52,"end":60},"obj":"CHEBI_PR_EXT:protein"},{"id":"T2073","span":{"begin":74,"end":91},"obj":"GO_EXT:0008237"},{"id":"T2074","span":{"begin":97,"end":103},"obj":"SO_EXT:0000417"},{"id":"T2075","span":{"begin":127,"end":133},"obj":"SO_EXT:0000417"},{"id":"T2076","span":{"begin":171,"end":184},"obj":"GO_MOP_EXT:catalysis"},{"id":"T2077","span":{"begin":192,"end":208},"obj":"GO_EXT:0008237"},{"id":"T2078","span":{"begin":256,"end":265},"obj":"GO_EXT:0005125"},{"id":"T2079","span":{"begin":267,"end":273},"obj":"GO_EXT:biological_growth_entity_or_process"},{"id":"T2080","span":{"begin":267,"end":281},"obj":"GO_EXT:0008083"},{"id":"T2081","span":{"begin":283,"end":292},"obj":"GO_EXT:0004872"},{"id":"T2082","span":{"begin":294,"end":302},"obj":"GO_PATO_EXT:biological_adhesion_entity_or_process"},{"id":"T2083","span":{"begin":303,"end":312},"obj":"CHEBI:36357"}],"attributes":[{"subj":"T2070","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2071","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2072","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2073","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2074","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2075","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2076","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2077","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2078","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2079","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2080","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2081","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2082","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2083","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-sa-dev","denotations":[{"id":"T2209","span":{"begin":4,"end":10},"obj":"NN"},{"id":"T2216","span":{"begin":2,"end":3},"obj":"-RRB-"},{"id":"T2217","span":{"begin":11,"end":20},"obj":"VBZ"},{"id":"T2218","span":{"begin":21,"end":29},"obj":"NN"},{"id":"T2219","span":{"begin":30,"end":38},"obj":"VBG"},{"id":"T2220","span":{"begin":29,"end":30},"obj":"HYPH"},{"id":"T2221","span":{"begin":52,"end":60},"obj":"NN"},{"id":"T2222","span":{"begin":39,"end":51},"obj":"JJ"},{"id":"T2223","span":{"begin":61,"end":71},"obj":"VBG"},{"id":"T2224","span":{"begin":72,"end":73},"obj":"DT"},{"id":"T2225","span":{"begin":97,"end":103},"obj":"NN"},{"id":"T2226","span":{"begin":74,"end":91},"obj":"NN"},{"id":"T2227","span":{"begin":92,"end":96},"obj":"JJ"},{"id":"T2228","span":{"begin":91,"end":92},"obj":"HYPH"},{"id":"T2229","span":{"begin":104,"end":107},"obj":"CC"},{"id":"T2230","span":{"begin":108,"end":109},"obj":"DT"},{"id":"T2231","span":{"begin":127,"end":133},"obj":"NN"},{"id":"T2232","span":{"begin":110,"end":121},"obj":"NN"},{"id":"T2233","span":{"begin":122,"end":126},"obj":"JJ"},{"id":"T2234","span":{"begin":121,"end":122},"obj":"HYPH"},{"id":"T2235","span":{"begin":133,"end":134},"obj":"."},{"id":"T2236","span":{"begin":134,"end":319},"obj":"sentence"},{"id":"T2237","span":{"begin":135,"end":148},"obj":"RB"},{"id":"T2238","span":{"begin":149,"end":153},"obj":"NN"},{"id":"T2239","span":{"begin":167,"end":170},"obj":"VBP"},{"id":"T2240","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T2241","span":{"begin":157,"end":160},"obj":"DT"},{"id":"T2242","span":{"begin":161,"end":166},"obj":"NNS"},{"id":"T2243","span":{"begin":171,"end":184},"obj":"RB"},{"id":"T2244","span":{"begin":185,"end":191},"obj":"JJ"},{"id":"T2245","span":{"begin":192,"end":208},"obj":"NNS"},{"id":"T2246","span":{"begin":209,"end":213},"obj":"WDT"},{"id":"T2247","span":{"begin":214,"end":218},"obj":"VBD"},{"id":"T2248","span":{"begin":219,"end":220},"obj":"DT"},{"id":"T2249","span":{"begin":227,"end":232},"obj":"NN"},{"id":"T2250","span":{"begin":221,"end":226},"obj":"JJ"},{"id":"T2251","span":{"begin":233,"end":235},"obj":"IN"},{"id":"T2252","span":{"begin":236,"end":246},"obj":"NNS"},{"id":"T2253","span":{"begin":246,"end":248},"obj":","},{"id":"T2254","span":{"begin":248,"end":252},"obj":"JJ"},{"id":"T2255","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T2256","span":{"begin":256,"end":265},"obj":"NNS"},{"id":"T2257","span":{"begin":265,"end":267},"obj":","},{"id":"T2258","span":{"begin":267,"end":273},"obj":"NN"},{"id":"T2259","span":{"begin":274,"end":281},"obj":"NNS"},{"id":"T2260","span":{"begin":281,"end":283},"obj":","},{"id":"T2261","span":{"begin":283,"end":292},"obj":"NNS"},{"id":"T2262","span":{"begin":292,"end":294},"obj":","},{"id":"T2263","span":{"begin":294,"end":302},"obj":"NN"},{"id":"T2264","span":{"begin":303,"end":312},"obj":"NNS"},{"id":"T2265","span":{"begin":313,"end":314},"obj":"-LRB-"},{"id":"T2266","span":{"begin":316,"end":317},"obj":"CD"},{"id":"T2267","span":{"begin":314,"end":315},"obj":"CD"},{"id":"T2268","span":{"begin":315,"end":316},"obj":","},{"id":"T2269","span":{"begin":317,"end":318},"obj":"-RRB-"},{"id":"T2270","span":{"begin":318,"end":319},"obj":"."},{"id":"T2272","span":{"begin":320,"end":326},"obj":"JJ"}],"relations":[{"id":"R223","pred":"nsubj","subj":"T2209","obj":"T2217"},{"id":"R230","pred":"punct","subj":"T2216","obj":"T2209"},{"id":"R231","pred":"npadvmod","subj":"T2218","obj":"T2219"},{"id":"R232","pred":"amod","subj":"T2219","obj":"T2221"},{"id":"R233","pred":"punct","subj":"T2220","obj":"T2219"},{"id":"R234","pred":"dobj","subj":"T2221","obj":"T2217"},{"id":"R235","pred":"amod","subj":"T2222","obj":"T2221"},{"id":"R236","pred":"acl","subj":"T2223","obj":"T2221"},{"id":"R237","pred":"det","subj":"T2224","obj":"T2225"},{"id":"R238","pred":"dobj","subj":"T2225","obj":"T2223"},{"id":"R239","pred":"npadvmod","subj":"T2226","obj":"T2227"},{"id":"R240","pred":"amod","subj":"T2227","obj":"T2225"},{"id":"R241","pred":"punct","subj":"T2228","obj":"T2227"},{"id":"R242","pred":"cc","subj":"T2229","obj":"T2225"},{"id":"R243","pred":"det","subj":"T2230","obj":"T2231"},{"id":"R244","pred":"conj","subj":"T2231","obj":"T2225"},{"id":"R245","pred":"npadvmod","subj":"T2232","obj":"T2233"},{"id":"R246","pred":"amod","subj":"T2233","obj":"T2231"},{"id":"R247","pred":"punct","subj":"T2234","obj":"T2233"},{"id":"R248","pred":"punct","subj":"T2235","obj":"T2217"},{"id":"R249","pred":"advmod","subj":"T2237","obj":"T2238"},{"id":"R250","pred":"nsubj","subj":"T2238","obj":"T2239"},{"id":"R251","pred":"prep","subj":"T2240","obj":"T2238"},{"id":"R252","pred":"det","subj":"T2241","obj":"T2242"},{"id":"R253","pred":"pobj","subj":"T2242","obj":"T2240"},{"id":"R254","pred":"advmod","subj":"T2243","obj":"T2244"},{"id":"R255","pred":"amod","subj":"T2244","obj":"T2245"},{"id":"R256","pred":"attr","subj":"T2245","obj":"T2239"},{"id":"R257","pred":"dep","subj":"T2246","obj":"T2247"},{"id":"R258","pred":"relcl","subj":"T2247","obj":"T2245"},{"id":"R259","pred":"det","subj":"T2248","obj":"T2249"},{"id":"R260","pred":"dobj","subj":"T2249","obj":"T2247"},{"id":"R261","pred":"amod","subj":"T2250","obj":"T2249"},{"id":"R262","pred":"prep","subj":"T2251","obj":"T2249"},{"id":"R263","pred":"pobj","subj":"T2252","obj":"T2251"},{"id":"R264","pred":"punct","subj":"T2253","obj":"T2252"},{"id":"R265","pred":"amod","subj":"T2254","obj":"T2255"},{"id":"R266","pred":"prep","subj":"T2255","obj":"T2252"},{"id":"R267","pred":"pobj","subj":"T2256","obj":"T2255"},{"id":"R268","pred":"punct","subj":"T2257","obj":"T2256"},{"id":"R269","pred":"compound","subj":"T2258","obj":"T2259"},{"id":"R270","pred":"appos","subj":"T2259","obj":"T2256"},{"id":"R271","pred":"punct","subj":"T2260","obj":"T2256"},{"id":"R272","pred":"appos","subj":"T2261","obj":"T2256"},{"id":"R273","pred":"punct","subj":"T2262","obj":"T2256"},{"id":"R274","pred":"compound","subj":"T2263","obj":"T2264"},{"id":"R275","pred":"appos","subj":"T2264","obj":"T2256"},{"id":"R276","pred":"punct","subj":"T2265","obj":"T2266"},{"id":"R277","pred":"parataxis","subj":"T2266","obj":"T2247"},{"id":"R278","pred":"nummod","subj":"T2267","obj":"T2266"},{"id":"R279","pred":"punct","subj":"T2268","obj":"T2266"},{"id":"R280","pred":"punct","subj":"T2269","obj":"T2266"},{"id":"R281","pred":"punct","subj":"T2270","obj":"T2239"}],"attributes":[{"subj":"T2209","pred":"source","obj":"craft-sa-dev"},{"subj":"T2216","pred":"source","obj":"craft-sa-dev"},{"subj":"T2217","pred":"source","obj":"craft-sa-dev"},{"subj":"T2218","pred":"source","obj":"craft-sa-dev"},{"subj":"T2219","pred":"source","obj":"craft-sa-dev"},{"subj":"T2220","pred":"source","obj":"craft-sa-dev"},{"subj":"T2221","pred":"source","obj":"craft-sa-dev"},{"subj":"T2222","pred":"source","obj":"craft-sa-dev"},{"subj":"T2223","pred":"source","obj":"craft-sa-dev"},{"subj":"T2224","pred":"source","obj":"craft-sa-dev"},{"subj":"T2225","pred":"source","obj":"craft-sa-dev"},{"subj":"T2226","pred":"source","obj":"craft-sa-dev"},{"subj":"T2227","pred":"source","obj":"craft-sa-dev"},{"subj":"T2228","pred":"source","obj":"craft-sa-dev"},{"subj":"T2229","pred":"source","obj":"craft-sa-dev"},{"subj":"T2230","pred":"source","obj":"craft-sa-dev"},{"subj":"T2231","pred":"source","obj":"craft-sa-dev"},{"subj":"T2232","pred":"source","obj":"craft-sa-dev"},{"subj":"T2233","pred":"source","obj":"craft-sa-dev"},{"subj":"T2234","pred":"source","obj":"craft-sa-dev"},{"subj":"T2235","pred":"source","obj":"craft-sa-dev"},{"subj":"T2236","pred":"source","obj":"craft-sa-dev"},{"subj":"T2237","pred":"source","obj":"craft-sa-dev"},{"subj":"T2238","pred":"source","obj":"craft-sa-dev"},{"subj":"T2239","pred":"source","obj":"craft-sa-dev"},{"subj":"T2240","pred":"source","obj":"craft-sa-dev"},{"subj":"T2241","pred":"source","obj":"craft-sa-dev"},{"subj":"T2242","pred":"source","obj":"craft-sa-dev"},{"subj":"T2243","pred":"source","obj":"craft-sa-dev"},{"subj":"T2244","pred":"source","obj":"craft-sa-dev"},{"subj":"T2245","pred":"source","obj":"craft-sa-dev"},{"subj":"T2246","pred":"source","obj":"craft-sa-dev"},{"subj":"T2247","pred":"source","obj":"craft-sa-dev"},{"subj":"T2248","pred":"source","obj":"craft-sa-dev"},{"subj":"T2249","pred":"source","obj":"craft-sa-dev"},{"subj":"T2250","pred":"source","obj":"craft-sa-dev"},{"subj":"T2251","pred":"source","obj":"craft-sa-dev"},{"subj":"T2252","pred":"source","obj":"craft-sa-dev"},{"subj":"T2253","pred":"source","obj":"craft-sa-dev"},{"subj":"T2254","pred":"source","obj":"craft-sa-dev"},{"subj":"T2255","pred":"source","obj":"craft-sa-dev"},{"subj":"T2256","pred":"source","obj":"craft-sa-dev"},{"subj":"T2257","pred":"source","obj":"craft-sa-dev"},{"subj":"T2258","pred":"source","obj":"craft-sa-dev"},{"subj":"T2259","pred":"source","obj":"craft-sa-dev"},{"subj":"T2260","pred":"source","obj":"craft-sa-dev"},{"subj":"T2261","pred":"source","obj":"craft-sa-dev"},{"subj":"T2262","pred":"source","obj":"craft-sa-dev"},{"subj":"T2263","pred":"source","obj":"craft-sa-dev"},{"subj":"T2264","pred":"source","obj":"craft-sa-dev"},{"subj":"T2265","pred":"source","obj":"craft-sa-dev"},{"subj":"T2266","pred":"source","obj":"craft-sa-dev"},{"subj":"T2267","pred":"source","obj":"craft-sa-dev"},{"subj":"T2268","pred":"source","obj":"craft-sa-dev"},{"subj":"T2269","pred":"source","obj":"craft-sa-dev"},{"subj":"T2270","pred":"source","obj":"craft-sa-dev"},{"subj":"T2272","pred":"source","obj":"craft-sa-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-ca-core-dev","color":"#93ec9b","default":true},{"id":"craft-ca-core-ex-dev","color":"#ec93a4"},{"id":"craft-sa-dev","color":"#93beec"}]}]}}