Clinical fields
The presence or absence of autoantibodies to p53 was compared with the clinical status of each patient, which was classified: (i) primary remission; (ii) secondary remission following a previous relapse; (iii) active relapsed disease; or (iv) continuous active disease since first diagnosis. For those patients who were anti-p53 positive, their clinical history was compared with levels of measured p53 autoantibodies throughout their follow-up period.