al differences cannot be excluded. Aims: The goal of this study was to investigate the expressions of ERC4, ERD5 and ERD3 variant messenger RNAs in normal breast tissues and their matched adjacent primary breast tumor tissues. Materials and methods: Eighteen cases were selected from the Manitoba Breast Tumor Bank, which had well separated and histopathologically characterized normal and adjacent neoplastic components. All tumors were classified as primary invasive ductal carcinomas. Six tumors were ER-negative/progesterone receptor (PR)-negative, nine were ER-positive/PR-positive, two were ER-positive/PR-negative, and one was ER-negative/PR-positive, as measured by ligand-binding assay. For each specimen, total RNA wa