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Id Subject Object Predicate Lexical cue
T3783 0-1 -RRB- denotes ]
T3784 1-2 . denotes .
T3785 2-187 sentence denotes A cell permeable calpain inhibitor (which likely inhibits other thiol-proteases as well) has been used to select cells lacking μ-calpain which display reduced proliferation rates [30].
T3786 3-4 DT denotes A
T3787 28-37 NN denotes inhibitor
T3788 5-9 NN denotes cell
T3789 10-19 JJ denotes permeable
T3790 20-27 NN denotes calpain
T3791 101-105 VBN denotes used
T3792 38-39 -LRB- denotes (
T3793 39-44 WDT denotes which
T3794 52-60 VBZ denotes inhibits
T3795 45-51 RB denotes likely
T3796 61-66 JJ denotes other
T3797 73-82 NNS denotes proteases
T3798 67-72 NN denotes thiol
T3799 72-73 HYPH denotes -
T3800 83-85 RB denotes as
T3801 86-90 RB denotes well
T3802 90-91 -RRB- denotes )
T3803 92-95 VBZ denotes has
T3804 96-100 VBN denotes been
T3805 106-108 TO denotes to
T3806 109-115 VB denotes select
T3807 116-121 NNS denotes cells
T3808 122-129 VBG denotes lacking
T3809 130-131 NN denotes μ
T3810 132-139 NN denotes calpain
T3811 131-132 HYPH denotes -
T3812 140-145 WDT denotes which
T3813 146-153 VBP denotes display
T3814 154-161 VBN denotes reduced
T3815 176-181 NNS denotes rates
T3816 162-175 NN denotes proliferation
T3817 182-183 -LRB- denotes [
T3818 183-185 CD denotes 30
T3819 185-186 -RRB- denotes ]
T3820 186-187 . denotes .
T3821 187-320 sentence denotes Interestingly, m-calpain expression persisted in these cells, suggesting a possible requirement of m-calpain for cell survival [30].
T3822 188-201 RB denotes Interestingly
T3823 224-233 VBD denotes persisted
T3824 201-203 , denotes ,
T3825 203-204 NN denotes m
T3826 205-212 NN denotes calpain
T3827 204-205 HYPH denotes -
T3828 213-223 NN denotes expression
T3829 234-236 IN denotes in
T3830 237-242 DT denotes these
T3831 243-248 NNS denotes cells
T3832 248-250 , denotes ,
T3833 250-260 VBG denotes suggesting
T3834 261-262 DT denotes a
T3835 272-283 NN denotes requirement
T3836 263-271 JJ denotes possible
T3837 284-286 IN denotes of
T3838 287-288 NN denotes m
T3839 289-296 NN denotes calpain
T3840 288-289 HYPH denotes -
T3841 297-300 IN denotes for
T3842 301-305 NN denotes cell
T3843 306-314 NN denotes survival
T3844 315-316 -LRB- denotes [
T3845 316-318 CD denotes 30
T3846 318-319 -RRB- denotes ]
T3847 319-320 . denotes .
T3848 320-505 sentence denotes Targeted gene deletion in mice provides a powerful approach to determining the physiological roles of μ- and m-calpain and the opportunity to approach their isoform specific functions.
T3849 321-329 VBN denotes Targeted
T3850 335-343 NN denotes deletion
T3851 330-334 NN denotes gene
T3852 352-360 VBZ denotes provides
T3853 344-346 IN denotes in
T3854 347-351 NNS denotes mice
T3855 361-362 DT denotes a
T3856 372-380 NN denotes approach
T3857 363-371 JJ denotes powerful
T3858 381-383 IN denotes to
T3859 384-395 VBG denotes determining
T3860 396-399 DT denotes the
T3861 414-419 NNS denotes roles
T3862 400-413 JJ denotes physiological
T3863 420-422 IN denotes of
T3864 423-424 NN denotes μ
T3865 432-439 NN denotes calpain
T3866 424-425 HYPH denotes -
T3867 426-429 CC denotes and
T3868 430-431 NN denotes m
T3869 431-432 HYPH denotes -
T3870 440-443 CC denotes and
T3871 444-447 DT denotes the
T3872 448-459 NN denotes opportunity
T3873 460-462 TO denotes to
T3874 463-471 VB denotes approach
T3875 472-477 PRP$ denotes their
T3876 495-504 NNS denotes functions
T3877 478-485 NN denotes isoform
T3878 486-494 JJ denotes specific
T3879 504-505 . denotes .
T3880 505-643 sentence denotes Initial studies targeted Capn4 based on the prediction that loss of this calpain subunit would abolish activity of both μ- and m-calpain.
T3881 506-513 JJ denotes Initial
T3882 514-521 NNS denotes studies
T3883 522-530 VBD denotes targeted
T3884 531-536 NN denotes Capn4
T3885 537-542 VBN denotes based
T3886 543-545 IN denotes on
T3887 546-549 DT denotes the
T3888 550-560 NN denotes prediction
T3889 561-565 IN denotes that
T3890 601-608 VB denotes abolish
T3891 566-570 NN denotes loss
T3892 571-573 IN denotes of
T3893 574-578 DT denotes this
T3894 587-594 NN denotes subunit
T3895 579-586 NN denotes calpain
T3896 595-600 MD denotes would
T3897 609-617 NN denotes activity
T3898 618-620 IN denotes of
T3899 621-625 CC denotes both
T3900 626-627 NN denotes μ
T3901 635-642 NN denotes calpain
T3902 627-628 HYPH denotes -
T3903 629-632 CC denotes and
T3904 633-634 NN denotes m
T3905 634-635 HYPH denotes -
T3906 642-643 . denotes .
T3907 643-796 sentence denotes Capn4-/- murine embryos died between days 10 and 11 of gestation, and there was no detectable μ- or m-calpain activity in these or younger embryos [31].
T3908 644-649 NN denotes Capn4
T3909 660-667 NNS denotes embryos
T3910 649-650 SYM denotes -
T3911 650-651 HYPH denotes /
T3912 651-652 SYM denotes -
T3913 653-659 JJ denotes murine
T3914 668-672 VBD denotes died
T3915 673-680 IN denotes between
T3916 681-685 NNS denotes days
T3917 686-688 CD denotes 10
T3918 689-692 CC denotes and
T3919 693-695 CD denotes 11
T3920 696-698 IN denotes of
T3921 699-708 NN denotes gestation
T3922 708-710 , denotes ,
T3923 710-713 CC denotes and
T3924 714-719 EX denotes there
T3925 720-723 VBD denotes was
T3926 724-726 DT denotes no
T3927 754-762 NN denotes activity
T3928 727-737 JJ denotes detectable
T3929 738-739 NN denotes μ
T3930 746-753 NN denotes calpain
T3931 739-740 HYPH denotes -
T3932 741-743 CC denotes or
T3933 744-745 NN denotes m
T3934 745-746 HYPH denotes -
T3935 763-765 IN denotes in
T3936 766-771 DT denotes these
T3937 772-774 CC denotes or
T3938 775-782 JJR denotes younger
T3939 783-790 NNS denotes embryos
T3940 791-792 -LRB- denotes [
T3941 792-794 CD denotes 31
T3942 794-795 -RRB- denotes ]
T3943 795-796 . denotes .
T3944 796-1129 sentence denotes Capn4-/- murine embryonic fibroblasts (MEFs) could be cultured from these embryos, although they also lacked calpain activity as assessed by casein zymography or by the formation of characteristic spectrin breakdown products, and they displayed migration defects consistent with a role for calpain in release of focal adhesions [9].
T3945 797-802 NN denotes Capn4
T3946 851-859 VBN denotes cultured
T3947 802-803 SYM denotes -
T3948 803-804 HYPH denotes /
T3949 804-805 SYM denotes -
T3950 806-812 JJ denotes murine
T3951 823-834 NNS denotes fibroblasts
T3952 813-822 JJ denotes embryonic
T3953 835-836 -LRB- denotes (
T3954 836-840 NNS denotes MEFs
T3955 840-841 -RRB- denotes )
T3956 842-847 MD denotes could
T3957 848-850 VB denotes be
T3958 860-864 IN denotes from
T3959 865-870 DT denotes these
T3960 871-878 NNS denotes embryos
T3961 878-880 , denotes ,
T3962 880-888 IN denotes although
T3963 899-905 VBD denotes lacked
T3964 889-893 PRP denotes they
T3965 894-898 RB denotes also
T3966 906-913 NN denotes calpain
T3967 914-922 NN denotes activity
T3968 923-925 IN denotes as
T3969 926-934 VBN denotes assessed
T3970 935-937 IN denotes by
T3971 938-944 NN denotes casein
T3972 945-955 NN denotes zymography
T3973 956-958 CC denotes or
T3974 959-961 IN denotes by
T3975 962-965 DT denotes the
T3976 966-975 NN denotes formation
T3977 976-978 IN denotes of
T3978 979-993 JJ denotes characteristic
T3979 1013-1021 NNS denotes products
T3980 994-1002 NN denotes spectrin
T3981 1003-1012 NN denotes breakdown
T3982 1021-1023 , denotes ,
T3983 1023-1026 CC denotes and
T3984 1027-1031 PRP denotes they
T3985 1032-1041 VBD denotes displayed
T3986 1042-1051 NN denotes migration
T3987 1052-1059 NNS denotes defects
T3988 1060-1070 JJ denotes consistent
T3989 1071-1075 IN denotes with
T3990 1076-1077 DT denotes a
T3991 1078-1082 NN denotes role
T3992 1083-1086 IN denotes for
T3993 1087-1094 NN denotes calpain
T3994 1095-1097 IN denotes in
T3995 1098-1105 NN denotes release
T3996 1106-1108 IN denotes of
T3997 1109-1114 JJ denotes focal
T3998 1115-1124 NNS denotes adhesions
T3999 1125-1126 -LRB- denotes [
T4000 1126-1127 CD denotes 9
T4001 1127-1128 -RRB- denotes ]
T4002 1128-1129 . denotes .
T4003 1129-1308 sentence denotes An independently derived Capn4 knockout, involving a more extensive deletion of the gene, resulted in an earlier embryonic lethality, apparently at a pre-implantation stage [32].
T4004 1130-1132 DT denotes An
T4005 1161-1169 NN denotes knockout
T4006 1133-1146 RB denotes independently
T4007 1147-1154 VBN denotes derived
T4008 1155-1160 NN denotes Capn4
T4009 1220-1228 VBD denotes resulted
T4010 1169-1171 , denotes ,
T4011 1171-1180 VBG denotes involving
T4012 1181-1182 DT denotes a
T4013 1198-1206 NN denotes deletion
T4014 1183-1187 RBR denotes more
T4015 1188-1197 JJ denotes extensive
T4016 1207-1209 IN denotes of
T4017 1210-1213 DT denotes the
T4018 1214-1218 NN denotes gene
T4019 1218-1220 , denotes ,
T4020 1229-1231 IN denotes in
T4021 1232-1234 DT denotes an
T4022 1253-1262 NN denotes lethality
T4023 1235-1242 JJR denotes earlier
T4024 1243-1252 JJ denotes embryonic
T4025 1262-1264 , denotes ,
T4026 1264-1274 RB denotes apparently
T4027 1275-1277 IN denotes at
T4028 1278-1279 DT denotes a
T4029 1297-1302 NN denotes stage
T4030 1280-1296 JJ denotes pre-implantation
T4031 1303-1304 -LRB- denotes [
T4032 1304-1306 CD denotes 32
T4033 1306-1307 -RRB- denotes ]
T4034 1307-1308 . denotes .
T4035 1308-1625 sentence denotes The different times of embryonic lethality suggested that the first reported Capn4-/- mice [31] were targeted with a hypomorphic mutation, which retained some small level of calpain activity, allowing for their survival to mid-gestation, while the second reported Capn4-/- mice [32] represented a true null mutation.
T4036 1309-1312 DT denotes The
T4037 1323-1328 NNS denotes times
T4038 1313-1322 JJ denotes different
T4039 1352-1361 VBD denotes suggested
T4040 1329-1331 IN denotes of
T4041 1332-1341 JJ denotes embryonic
T4042 1342-1351 NN denotes lethality
T4043 1362-1366 IN denotes that
T4044 1410-1418 VBN denotes targeted
T4045 1367-1370 DT denotes the
T4046 1395-1399 NNS denotes mice
T4047 1371-1376 JJ denotes first
T4048 1377-1385 VBN denotes reported
T4049 1386-1391 NN denotes Capn4
T4050 1391-1392 SYM denotes -
T4051 1392-1393 HYPH denotes /
T4052 1393-1394 SYM denotes -
T4053 1400-1401 -LRB- denotes [
T4054 1401-1403 CD denotes 31
T4055 1403-1404 -RRB- denotes ]
T4056 1405-1409 VBD denotes were
T4057 1419-1423 IN denotes with
T4058 1424-1425 DT denotes a
T4059 1438-1446 NN denotes mutation
T4060 1426-1437 JJ denotes hypomorphic
T4061 1446-1448 , denotes ,
T4062 1448-1453 WDT denotes which
T4063 1454-1462 VBD denotes retained
T4064 1463-1467 DT denotes some
T4065 1474-1479 NN denotes level
T4066 1468-1473 JJ denotes small
T4067 1480-1482 IN denotes of
T4068 1483-1490 NN denotes calpain
T4069 1491-1499 NN denotes activity
T4070 1499-1501 , denotes ,
T4071 1501-1509 VBG denotes allowing
T4072 1510-1513 IN denotes for
T4073 1514-1519 PRP$ denotes their
T4074 1520-1528 NN denotes survival
T4075 1529-1531 IN denotes to
T4076 1532-1545 NN denotes mid-gestation
T4077 1545-1547 , denotes ,
T4078 1547-1552 IN denotes while
T4079 1592-1603 VBD denotes represented
T4080 1553-1556 DT denotes the
T4081 1582-1586 NNS denotes mice
T4082 1557-1563 JJ denotes second
T4083 1564-1572 VBN denotes reported
T4084 1573-1578 NN denotes Capn4
T4085 1578-1579 SYM denotes -
T4086 1579-1580 HYPH denotes /
T4087 1580-1581 SYM denotes -
T4088 1587-1588 -LRB- denotes [
T4089 1588-1590 CD denotes 32
T4090 1590-1591 -RRB- denotes ]
T4091 1604-1605 DT denotes a
T4092 1616-1624 NN denotes mutation
T4093 1606-1610 JJ denotes true
T4094 1611-1615 JJ denotes null
T4095 1624-1625 . denotes .
T4096 1625-1859 sentence denotes Disruption of Capn1, encoding the μ-calpain catalytic subunit, was subsequently reported to result in fertile, viable mice with some mild defects in the μ-calpain rich platelets relating to their aggregation and clot retraction [33].
T4097 1626-1636 NN denotes Disruption
T4098 1706-1714 VBN denotes reported
T4099 1637-1639 IN denotes of
T4100 1640-1645 NN denotes Capn1
T4101 1645-1647 , denotes ,
T4102 1647-1655 VBG denotes encoding
T4103 1656-1659 DT denotes the
T4104 1680-1687 NN denotes subunit
T4105 1660-1661 NN denotes μ
T4106 1662-1669 NN denotes calpain
T4107 1661-1662 HYPH denotes -
T4108 1670-1679 JJ denotes catalytic
T4109 1687-1689 , denotes ,
T4110 1689-1692 VBD denotes was
T4111 1693-1705 RB denotes subsequently
T4112 1715-1717 TO denotes to
T4113 1718-1724 VB denotes result
T4114 1725-1727 IN denotes in
T4115 1728-1735 JJ denotes fertile
T4116 1744-1748 NNS denotes mice
T4117 1735-1737 , denotes ,
T4118 1737-1743 JJ denotes viable
T4119 1749-1753 IN denotes with
T4120 1754-1758 DT denotes some
T4121 1764-1771 NNS denotes defects
T4122 1759-1763 JJ denotes mild
T4123 1772-1774 IN denotes in
T4124 1775-1778 DT denotes the
T4125 1794-1803 NNS denotes platelets
T4126 1779-1780 NN denotes μ
T4127 1781-1788 NN denotes calpain
T4128 1780-1781 HYPH denotes -
T4129 1789-1793 JJ denotes rich
T4130 1804-1812 VBG denotes relating
T4131 1813-1815 IN denotes to
T4132 1816-1821 PRP$ denotes their
T4133 1822-1833 NN denotes aggregation
T4134 1834-1837 CC denotes and
T4135 1838-1842 NN denotes clot
T4136 1843-1853 NN denotes retraction
T4137 1854-1855 -LRB- denotes [
T4138 1855-1857 CD denotes 33
T4139 1857-1858 -RRB- denotes ]
T4140 1858-1859 . denotes .
T4141 1859-2007 sentence denotes The fact that Capn4 null mice die during embryogenesis indicates that at least one of the ubiquitous calpains is essential for development to term.
T4142 1860-1863 DT denotes The
T4143 1864-1868 NN denotes fact
T4144 1915-1924 VBZ denotes indicates
T4145 1869-1873 IN denotes that
T4146 1890-1893 VBP denotes die
T4147 1874-1879 NN denotes Capn4
T4148 1880-1884 JJ denotes null
T4149 1885-1889 NNS denotes mice
T4150 1894-1900 IN denotes during
T4151 1901-1914 NN denotes embryogenesis
T4152 1925-1929 IN denotes that
T4153 1970-1972 VBZ denotes is
T4154 1930-1932 RB denotes at
T4155 1939-1942 CD denotes one
T4156 1933-1938 RBS denotes least
T4157 1943-1945 IN denotes of
T4158 1946-1949 DT denotes the
T4159 1961-1969 NNS denotes calpains
T4160 1950-1960 JJ denotes ubiquitous
T4161 1973-1982 JJ denotes essential
T4162 1983-1986 IN denotes for
T4163 1987-1998 NN denotes development
T4164 1999-2001 IN denotes to
T4165 2002-2006 NN denotes term
T4166 2006-2007 . denotes .
T4167 2007-2270 sentence denotes The viability of Capn1-deficient mice does not however distinguish between two possibilities: either that m-calpain is specifically required during embryogenesis, or that either form of calpain alone is sufficient and can compensate for the absence of the other.
T4168 2008-2011 DT denotes The
T4169 2012-2021 NN denotes viability
T4170 2063-2074 VB denotes distinguish
T4171 2022-2024 IN denotes of
T4172 2025-2030 NN denotes Capn1
T4173 2031-2040 JJ denotes deficient
T4174 2030-2031 HYPH denotes -
T4175 2041-2045 NNS denotes mice
T4176 2046-2050 VBZ denotes does
T4177 2051-2054 RB denotes not
T4178 2055-2062 RB denotes however
T4179 2075-2082 IN denotes between
T4180 2083-2086 CD denotes two
T4181 2087-2100 NNS denotes possibilities
T4182 2100-2102 : denotes :
T4183 2102-2108 CC denotes either
T4184 2140-2148 VBN denotes required
T4185 2109-2113 IN denotes that
T4186 2114-2115 NN denotes m
T4187 2116-2123 NN denotes calpain
T4188 2115-2116 HYPH denotes -
T4189 2124-2126 VBZ denotes is
T4190 2127-2139 RB denotes specifically
T4191 2149-2155 IN denotes during
T4192 2156-2169 NN denotes embryogenesis
T4193 2169-2171 , denotes ,
T4194 2171-2173 CC denotes or
T4195 2174-2178 IN denotes that
T4196 2208-2210 VBZ denotes is
T4197 2179-2185 CC denotes either
T4198 2186-2190 NN denotes form
T4199 2191-2193 IN denotes of
T4200 2194-2201 NN denotes calpain
T4201 2202-2207 RB denotes alone
T4202 2211-2221 JJ denotes sufficient
T4203 2222-2225 CC denotes and
T4204 2226-2229 MD denotes can
T4205 2230-2240 VB denotes compensate
T4206 2241-2244 IN denotes for
T4207 2245-2248 DT denotes the
T4208 2249-2256 NN denotes absence
T4209 2257-2259 IN denotes of
T4210 2260-2263 DT denotes the
T4211 2264-2269 JJ denotes other
T4212 2269-2270 . denotes .
T4213 2270-2372 sentence denotes To resolve this question, we have now knocked out the Capn2 gene encoding the m-80 k subunit in mice.
T4214 2271-2273 TO denotes To
T4215 2274-2281 VB denotes resolve
T4216 2309-2316 VBN denotes knocked
T4217 2282-2286 DT denotes this
T4218 2287-2295 NN denotes question
T4219 2295-2297 , denotes ,
T4220 2297-2299 PRP denotes we
T4221 2300-2304 VBP denotes have
T4222 2305-2308 RB denotes now
T4223 2317-2320 RP denotes out
T4224 2321-2324 DT denotes the
T4225 2331-2335 NN denotes gene
T4226 2325-2330 NN denotes Capn2
T4227 2336-2344 VBG denotes encoding
T4228 2345-2348 DT denotes the
T4229 2356-2363 NN denotes subunit
T4230 2349-2350 NN denotes m
T4231 2354-2355 NN denotes k
T4232 2350-2351 HYPH denotes -
T4233 2351-2353 CD denotes 80
T4234 2364-2366 IN denotes in
T4235 2367-2371 NNS denotes mice
T4236 2371-2372 . denotes .
T4237 2372-2517 sentence denotes We report here that Capn2 null embryos died prior to the implantation stage, indicating that m-calpain is indispensable for early embryogenesis.
T4238 2373-2375 PRP denotes We
T4239 2376-2382 VBP denotes report
T4240 2383-2387 RB denotes here
T4241 2388-2392 IN denotes that
T4242 2412-2416 VBD denotes died
T4243 2393-2398 NN denotes Capn2
T4244 2399-2403 JJ denotes null
T4245 2404-2411 NNS denotes embryos
T4246 2417-2422 JJ denotes prior
T4247 2423-2425 IN denotes to
T4248 2426-2429 DT denotes the
T4249 2443-2448 NN denotes stage
T4250 2430-2442 NN denotes implantation
T4251 2448-2450 , denotes ,
T4252 2450-2460 VBG denotes indicating
T4253 2461-2465 IN denotes that
T4254 2476-2478 VBZ denotes is
T4255 2466-2467 NN denotes m
T4256 2468-2475 NN denotes calpain
T4257 2467-2468 HYPH denotes -
T4258 2479-2492 JJ denotes indispensable
T4259 2493-2496 IN denotes for
T4260 2497-2502 JJ denotes early
T4261 2503-2516 NN denotes embryogenesis
T4262 2516-2517 . denotes .
T4263 2517-2671 sentence denotes This role cannot be fulfilled by μ-calpain, which is expressed in embryonic stem (ES) cells [31] and is assumed to be present at this stage of gestation.
T4264 2518-2522 DT denotes This
T4265 2523-2527 NN denotes role
T4266 2538-2547 VBN denotes fulfilled
T4267 2528-2531 MD denotes can
T4268 2531-2534 RB denotes not
T4269 2535-2537 VB denotes be
T4270 2548-2550 IN denotes by
T4271 2551-2552 NN denotes μ
T4272 2553-2560 NN denotes calpain
T4273 2552-2553 HYPH denotes -
T4274 2560-2562 , denotes ,
T4275 2562-2567 WDT denotes which
T4276 2571-2580 VBN denotes expressed
T4277 2568-2570 VBZ denotes is
T4278 2581-2583 IN denotes in
T4279 2584-2593 JJ denotes embryonic
T4280 2594-2598 NN denotes stem
T4281 2604-2609 NNS denotes cells
T4282 2599-2600 -LRB- denotes (
T4283 2600-2602 NN denotes ES
T4284 2602-2603 -RRB- denotes )
T4285 2610-2611 -LRB- denotes [
T4286 2611-2613 CD denotes 31
T4287 2613-2614 -RRB- denotes ]
T4288 2615-2618 CC denotes and
T4289 2619-2621 VBZ denotes is
T4290 2622-2629 VBN denotes assumed
T4291 2630-2632 TO denotes to
T4292 2633-2635 VB denotes be
T4293 2636-2643 JJ denotes present
T4294 2644-2646 IN denotes at
T4295 2647-2651 DT denotes this
T4296 2652-2657 NN denotes stage
T4297 2658-2660 IN denotes of
T4298 2661-2670 NN denotes gestation
T4299 2670-2671 . denotes .
T4300 2671-2794 sentence denotes This demonstrates unequivocally that m-calpain and μ-calpain have distinct physiological roles during early embryogenesis.
T4301 2672-2676 DT denotes This
T4302 2677-2689 VBZ denotes demonstrates
T4303 2690-2703 RB denotes unequivocally
T4304 2704-2708 IN denotes that
T4305 2733-2737 VBP denotes have
T4306 2709-2710 NN denotes m
T4307 2711-2718 NN denotes calpain
T4308 2710-2711 HYPH denotes -
T4309 2719-2722 CC denotes and
T4310 2723-2724 NN denotes μ
T4311 2725-2732 NN denotes calpain
T4312 2724-2725 HYPH denotes -
T4313 2738-2746 JJ denotes distinct
T4314 2761-2766 NNS denotes roles
T4315 2747-2760 JJ denotes physiological
T4316 2767-2773 IN denotes during
T4317 2774-2779 JJ denotes early
T4318 2780-2793 NN denotes embryogenesis
T4319 2793-2794 . denotes .
T4832 2805-2814 NN denotes Isolation
T4833 2815-2818 CC denotes and
T4834 2819-2835 NN denotes characterization
T4835 2836-2838 IN denotes of
T4836 2839-2844 NN denotes Capn2
T4837 2845-2853 VBN denotes targeted
T4839 2854-2856 NN denotes ES
T4840 2857-2861 NN denotes cell
R723 T3786 T3787 det A,inhibitor
R725 T3787 T3791 nsubjpass inhibitor,used
R726 T3788 T3789 npadvmod cell,permeable
R727 T3789 T3787 amod permeable,inhibitor
R728 T3790 T3787 compound calpain,inhibitor
R730 T3792 T3787 punct (,inhibitor
R732 T3793 T3794 dep which,inhibits
R733 T3794 T3787 relcl inhibits,inhibitor
R734 T3795 T3794 advmod likely,inhibits
R736 T3796 T3797 amod other,proteases
R737 T3797 T3794 dobj proteases,inhibits
R738 T3798 T3797 compound thiol,proteases
R739 T3799 T3797 punct -,proteases
R740 T3800 T3801 advmod as,well
R741 T3801 T3794 advmod well,inhibits
R742 T3802 T3791 punct ),used
R744 T3803 T3791 aux has,used
R745 T3804 T3791 auxpass been,used
R746 T3805 T3806 aux to,select
R748 T3806 T3791 advcl select,used
R749 T3807 T3806 dobj cells,select
R750 T3808 T3807 acl lacking,cells
R751 T3809 T3810 compound μ,calpain
R754 T3810 T3808 dobj calpain,lacking
R756 T3811 T3810 punct -,calpain
R757 T3812 T3813 dep which,display
R758 T3813 T3807 relcl display,cells
R760 T3814 T3815 amod reduced,rates
R761 T3815 T3813 dobj rates,display
R762 T3816 T3815 compound proliferation,rates
R764 T3817 T3818 punct [,30
R765 T3818 T3813 parataxis 30,display
R766 T3819 T3818 punct ],30
R768 T3820 T3791 punct .,used
R770 T3822 T3823 advmod Interestingly,persisted
R772 T3824 T3823 punct ", ",persisted
R773 T3825 T3826 compound m,calpain
R774 T3826 T3828 compound calpain,expression
R776 T3827 T3826 punct -,calpain
R777 T3828 T3823 nsubj expression,persisted
R778 T3829 T3823 prep in,persisted
R780 T3830 T3831 det these,cells
R781 T3831 T3829 pobj cells,in
R782 T3832 T3823 punct ", ",persisted
R784 T3833 T3823 advcl suggesting,persisted
R785 T3834 T3835 det a,requirement
R786 T3835 T3833 dobj requirement,suggesting
R788 T3836 T3835 amod possible,requirement
R789 T3837 T3835 prep of,requirement
R791 T3838 T3839 compound m,calpain
R792 T3839 T3837 pobj calpain,of
R793 T3840 T3839 punct -,calpain
R794 T3841 T3835 prep for,requirement
R795 T3842 T3843 compound cell,survival
R796 T3843 T3841 pobj survival,for
R798 T3844 T3845 punct [,30
R799 T3845 T3823 parataxis 30,persisted
R800 T3846 T3845 punct ],30
R802 T3847 T3823 punct .,persisted
R804 T3849 T3850 amod Targeted,deletion
R807 T3850 T3852 nsubj deletion,provides
R809 T3851 T3850 compound gene,deletion
R810 T3853 T3850 prep in,deletion
R812 T3854 T3853 pobj mice,in
R813 T3855 T3856 det a,approach
R815 T3856 T3852 dobj approach,provides
R817 T3857 T3856 amod powerful,approach
R818 T3858 T3856 prep to,approach
R819 T3859 T3858 pcomp determining,to
R820 T3860 T3861 det the,roles
R822 T3861 T3859 dobj roles,determining
R823 T3862 T3861 amod physiological,roles
R824 T3863 T3861 prep of,roles
R826 T3864 T3865 nmod μ,calpain
R827 T3865 T3863 pobj calpain,of
R829 T3866 T3864 punct -,μ
R830 T3867 T3864 cc and,μ
R831 T3868 T3864 conj m,μ
R833 T3869 T3865 punct -,calpain
R834 T3870 T3856 cc and,approach
R835 T3871 T3872 det the,opportunity
R837 T3872 T3856 conj opportunity,approach
R838 T3873 T3874 aux to,approach
R840 T3874 T3872 acl approach,opportunity
R841 T3875 T3876 poss their,functions
R842 T3876 T3874 dobj functions,approach
R843 T3877 T3878 npadvmod isoform,specific
R844 T3878 T3876 amod specific,functions
R845 T3879 T3852 punct .,provides
R847 T3881 T3882 amod Initial,studies
R848 T3882 T3883 nsubj studies,targeted
R850 T3884 T3883 dobj Capn4,targeted
R851 T3885 T3883 prep based,targeted
R853 T3886 T3885 prep on,based
R854 T3887 T3888 det the,prediction
R855 T3888 T3886 pobj prediction,on
R856 T3889 T3890 mark that,abolish
R858 T3890 T3888 acl abolish,prediction
R860 T3891 T3890 nsubj loss,abolish
R861 T3892 T3891 prep of,loss
R862 T3893 T3894 det this,subunit
R863 T3894 T3892 pobj subunit,of
R865 T3895 T3894 compound calpain,subunit
R866 T3896 T3890 aux would,abolish
R868 T3897 T3890 dobj activity,abolish
R870 T3898 T3897 prep of,activity
R871 T3899 T3900 preconj both,μ
R873 T3900 T3901 nmod μ,calpain
R874 T3901 T3898 pobj calpain,of
R876 T3902 T3900 punct -,μ
R877 T3903 T3900 cc and,μ
R878 T3904 T3900 conj m,μ
R880 T3905 T3901 punct -,calpain
R881 T3906 T3883 punct .,targeted
R882 T3908 T3909 nmod Capn4,embryos
R884 T3909 T3914 nsubj embryos,died
R885 T3910 T3908 punct -,Capn4
R886 T3911 T3908 punct /,Capn4
R888 T3912 T3908 punct -,Capn4
R889 T3913 T3909 amod murine,embryos
R891 T3915 T3914 prep between,died
R892 T3916 T3917 nmod days,10
R894 T3917 T3915 pobj 10,between
R895 T3918 T3917 cc and,10
R896 T3919 T3917 conj 11,10
R897 T3920 T3917 prep of,10
R898 T3921 T3920 pobj gestation,of
R899 T3922 T3914 punct ", ",died
R901 T3923 T3914 cc and,died
R902 T3924 T3925 expl there,was
R903 T3925 T3914 conj was,died
R905 T3926 T3927 det no,activity
R906 T3927 T3925 attr activity,was
R907 T3928 T3927 amod detectable,activity
R909 T3929 T3930 nmod μ,calpain
R910 T3930 T3927 compound calpain,activity
R911 T3931 T3929 punct -,μ
R913 T3932 T3929 cc or,μ
R914 T3933 T3929 conj m,μ
R916 T3934 T3930 punct -,calpain
R917 T3935 T3925 prep in,was
R918 T3936 T3935 pobj these,in
R919 T3937 T3936 cc or,these
R921 T3938 T3939 amod younger,embryos
R922 T3939 T3936 conj embryos,these
R924 T3940 T3941 punct [,31
R925 T3941 T3925 parataxis 31,was
R926 T3942 T3941 punct ],31
R928 T3943 T3925 punct .,was
R929 T3945 T3946 nsubjpass Capn4,cultured
R931 T3947 T3945 punct -,Capn4
R932 T3948 T3945 punct /,Capn4
R934 T3949 T3945 punct -,Capn4
R935 T3950 T3951 amod murine,fibroblasts
R938 T3951 T3945 appos fibroblasts,Capn4
R940 T3952 T3951 amod embryonic,fibroblasts
R942 T3953 T3951 punct (,fibroblasts
R943 T3954 T3951 appos MEFs,fibroblasts
R946 T3955 T3946 punct ),cultured
R948 T3956 T3946 aux could,cultured
R949 T3957 T3946 auxpass be,cultured
R950 T3958 T3946 prep from,cultured
R951 T3959 T3960 det these,embryos
R952 T3960 T3958 pobj embryos,from
R953 T3961 T3946 punct ", ",cultured
R954 T3962 T3963 mark although,lacked
R956 T3963 T3946 advcl lacked,cultured
R957 T3964 T3963 nsubj they,lacked
R958 T3965 T3963 advmod also,lacked
R960 T3966 T3967 compound calpain,activity
R961 T3967 T3963 dobj activity,lacked
R962 T3968 T3969 mark as,assessed
R963 T3969 T3963 advcl assessed,lacked
R965 T3970 T3969 prep by,assessed
R966 T3971 T3972 compound casein,zymography
R967 T3972 T3970 pobj zymography,by
R969 T3973 T3970 cc or,by
R970 T3974 T3970 conj by,by
R972 T3975 T3976 det the,formation
R973 T3976 T3974 pobj formation,by
R975 T3977 T3976 prep of,formation
R976 T3978 T3979 amod characteristic,products
R977 T3979 T3977 pobj products,of
R979 T3980 T3981 compound spectrin,breakdown
R980 T3981 T3979 compound breakdown,products
R983 T3982 T3963 punct ", ",lacked
R984 T3983 T3963 cc and,lacked
R986 T3984 T3985 nsubj they,displayed
R987 T3985 T3963 conj displayed,lacked
R988 T3986 T3987 compound migration,defects
R990 T3987 T3985 dobj defects,displayed
R991 T3988 T3987 amod consistent,defects
R992 T3989 T3988 prep with,consistent
R994 T3990 T3991 det a,role
R995 T3991 T3989 pobj role,with
R997 T3992 T3991 prep for,role
R998 T3993 T3992 pobj calpain,for
R999 T3994 T3991 prep in,role
R1000 T3995 T3994 pobj release,in
R1001 T3996 T3995 prep of,release
R1002 T3997 T3998 amod focal,adhesions
R1003 T4061 T4059 punct ", ",mutation
R1004 T3998 T3996 pobj adhesions,of
R1005 T3999 T4000 punct [,9
R1006 T4000 T3985 parataxis 9,displayed
R1007 T4001 T4000 punct ],9
R1008 T4002 T3946 punct .,cultured
R1009 T4062 T4063 dep which,retained
R1010 T4004 T4005 det An,knockout
R1011 T4005 T4009 nsubj knockout,resulted
R1012 T4063 T4059 relcl retained,mutation
R1013 T4006 T4007 advmod independently,derived
R1014 T4007 T4005 amod derived,knockout
R1015 T4008 T4005 compound Capn4,knockout
R1016 T4064 T4065 det some,level
R1017 T4010 T4005 punct ", ",knockout
R1018 T4011 T4005 prep involving,knockout
R1019 T4065 T4063 dobj level,retained
R1020 T4012 T4013 det a,deletion
R1021 T4013 T4011 pobj deletion,involving
R1022 T4014 T4015 advmod more,extensive
R1023 T4066 T4065 amod small,level
R1024 T4015 T4013 amod extensive,deletion
R1025 T4016 T4013 prep of,deletion
R1026 T4067 T4065 prep of,level
R1027 T4017 T4018 det the,gene
R1028 T4018 T4016 pobj gene,of
R1029 T4019 T4009 punct ", ",resulted
R1030 T4020 T4009 prep in,resulted
R1031 T4068 T4069 compound calpain,activity
R1032 T4021 T4022 det an,lethality
R1033 T4022 T4020 pobj lethality,in
R1034 T4069 T4067 pobj activity,of
R1035 T4023 T4022 amod earlier,lethality
R1036 T4024 T4022 amod embryonic,lethality
R1037 T4025 T4009 punct ", ",resulted
R1038 T4070 T4044 punct ", ",targeted
R1039 T4026 T4027 advmod apparently,at
R1040 T4027 T4009 prep at,resulted
R1041 T4028 T4029 det a,stage
R1042 T4029 T4027 pobj stage,at
R1043 T4071 T4044 advcl allowing,targeted
R1044 T4030 T4029 amod pre-implantation,stage
R1045 T4031 T4032 punct [,32
R1046 T4032 T4009 parataxis 32,resulted
R1047 T4072 T4071 prep for,allowing
R1048 T4033 T4032 punct ],32
R1049 T4034 T4009 punct .,resulted
R1050 T4073 T4074 poss their,survival
R1051 T4036 T4037 det The,times
R1052 T4037 T4039 nsubj times,suggested
R1053 T4038 T4037 amod different,times
R1054 T4040 T4037 prep of,times
R1055 T4074 T4072 pobj survival,for
R1056 T4041 T4042 amod embryonic,lethality
R1057 T4042 T4040 pobj lethality,of
R1058 T4043 T4044 mark that,targeted
R1060 T4044 T4039 ccomp targeted,suggested
R1061 T4045 T4046 det the,mice
R1062 T4046 T4044 nsubjpass mice,targeted
R1063 T4076 T4075 pobj mid-gestation,to
R1064 T4047 T4046 amod first,mice
R1065 T4048 T4046 amod reported,mice
R1066 T4077 T4044 punct ", ",targeted
R1067 T4078 T4079 mark while,represented
R1068 T4079 T4044 advcl represented,targeted
R1069 T4080 T4081 det the,mice
R1071 T4082 T4081 amod second,mice
R1072 T4083 T4081 amod reported,mice
R1073 T4084 T4081 nmod Capn4,mice
R1074 T4085 T4084 punct -,Capn4
R1075 T4086 T4084 punct /,Capn4
R1076 T4087 T4084 punct -,Capn4
R1077 T4088 T4089 punct [,32
R1078 T4049 T4046 nmod Capn4,mice
R1079 T4089 T4081 parataxis 32,mice
R1080 T4090 T4089 punct ],32
R1081 T4050 T4049 punct -,Capn4
R1082 T4091 T4092 det a,mutation
R1083 T4051 T4049 punct /,Capn4
R1084 T4052 T4049 punct -,Capn4
R1085 T4092 T4079 dobj mutation,represented
R1086 T4053 T4054 punct [,31
R1087 T4054 T4046 parataxis 31,mice
R1088 T4093 T4092 amod true,mutation
R1089 T4055 T4054 punct ],31
R1090 T4094 T4092 amod null,mutation
R1091 T4056 T4044 auxpass were,targeted
R1092 T4057 T4044 prep with,targeted
R1093 T4058 T4059 det a,mutation
R1094 T4095 T4039 punct .,suggested
R1095 T4059 T4057 pobj mutation,with
R1096 T4060 T4059 amod hypomorphic,mutation
R1097 T4097 T4098 nsubjpass Disruption,reported
R1098 T4099 T4097 prep of,Disruption
R1099 T4100 T4099 pobj Capn1,of
R1100 T4101 T4097 punct ", ",Disruption
R1101 T4102 T4097 acl encoding,Disruption
R1102 T4168 T4169 det The,viability
R1103 T4169 T4170 nsubj viability,distinguish
R1104 T4171 T4169 prep of,viability
R1105 T4172 T4173 npadvmod Capn1,deficient
R1106 T4173 T4175 amod deficient,mice
R1107 T4174 T4173 punct -,deficient
R1108 T4103 T4104 det the,subunit
R1109 T4175 T4171 pobj mice,of
R1110 T4176 T4170 aux does,distinguish
R1111 T4177 T4170 neg not,distinguish
R1112 T4104 T4102 dobj subunit,encoding
R1113 T4178 T4170 advmod however,distinguish
R1114 T4179 T4170 prep between,distinguish
R1115 T4180 T4181 nummod two,possibilities
R1116 T4105 T4106 nmod μ,calpain
R1117 T4181 T4179 pobj possibilities,between
R1118 T4182 T4181 punct : ,possibilities
R1119 T4106 T4104 nmod calpain,subunit
R1120 T4183 T4184 preconj either,required
R1121 T4184 T4181 advcl required,possibilities
R1122 T4185 T4184 mark that,required
R1123 T4107 T4106 punct -,calpain
R1124 T4186 T4187 compound m,calpain
R1125 T4187 T4184 nsubjpass calpain,required
R1126 T4188 T4187 punct -,calpain
R1127 T4108 T4104 amod catalytic,subunit
R1128 T4189 T4184 auxpass is,required
R1129 T4190 T4184 advmod specifically,required
R1130 T4109 T4098 punct ", ",reported
R1131 T4191 T4184 prep during,required
R1132 T4192 T4191 pobj embryogenesis,during
R1133 T4193 T4184 punct ", ",required
R1134 T4110 T4098 auxpass was,reported
R1135 T4194 T4184 cc or,required
R1136 T4195 T4196 mark that,is
R1137 T4196 T4184 conj is,required
R1138 T4111 T4098 advmod subsequently,reported
R1139 T4197 T4198 preconj either,form
R1140 T4198 T4196 nsubj form,is
R1141 T4199 T4198 prep of,form
R1142 T4112 T4113 aux to,result
R1143 T4200 T4199 pobj calpain,of
R1144 T4201 T4198 advmod alone,form
R1145 T4202 T4196 acomp sufficient,is
R1146 T4113 T4098 xcomp result,reported
R1147 T4203 T4196 cc and,is
R1148 T4204 T4205 aux can,compensate
R1149 T4114 T4113 prep in,result
R1150 T4205 T4196 conj compensate,is
R1151 T4206 T4205 prep for,compensate
R1152 T4207 T4208 det the,absence
R1153 T4115 T4116 amod fertile,mice
R1154 T4208 T4206 pobj absence,for
R1155 T4209 T4208 prep of,absence
R1156 T4210 T4211 det the,other
R1157 T4211 T4209 pobj other,of
R1158 T4212 T4170 punct .,distinguish
R1159 T4116 T4114 pobj mice,in
R1160 T4214 T4215 aux To,resolve
R1161 T4215 T4216 advcl resolve,knocked
R1162 T4117 T4116 punct ", ",mice
R1163 T4217 T4218 det this,question
R1164 T4218 T4215 dobj question,resolve
R1165 T4118 T4116 amod viable,mice
R1166 T4219 T4216 punct ", ",knocked
R1167 T4220 T4216 nsubj we,knocked
R1168 T4221 T4216 aux have,knocked
R1169 T4119 T4116 prep with,mice
R1170 T4222 T4216 advmod now,knocked
R1171 T4223 T4216 prt out,knocked
R1172 T4224 T4225 det the,gene
R1173 T4120 T4121 det some,defects
R1174 T4225 T4216 dobj gene,knocked
R1175 T4226 T4225 compound Capn2,gene
R1176 T4227 T4225 acl encoding,gene
R1177 T4121 T4119 pobj defects,with
R1178 T4228 T4229 det the,subunit
R1179 T4229 T4227 dobj subunit,encoding
R1180 T4230 T4231 nmod m,k
R1181 T4122 T4121 amod mild,defects
R1182 T4231 T4229 compound k,subunit
R1183 T4232 T4231 punct -,k
R1184 T4233 T4231 nummod 80,k
R1185 T4123 T4121 prep in,defects
R1186 T4234 T4227 prep in,encoding
R1187 T4124 T4125 det the,platelets
R1188 T4125 T4123 pobj platelets,in
R1189 T4126 T4127 compound μ,calpain
R1190 T4235 T4234 pobj mice,in
R1191 T4236 T4216 punct .,knocked
R1192 T4127 T4129 npadvmod calpain,rich
R1193 T4238 T4239 nsubj We,report
R1194 T4128 T4127 punct -,calpain
R1195 T4240 T4239 advmod here,report
R1196 T4241 T4242 mark that,died
R1197 T4242 T4239 ccomp died,report
R1198 T4129 T4125 amod rich,platelets
R1199 T4243 T4244 npadvmod Capn2,null
R1200 T4244 T4245 amod null,embryos
R1201 T4130 T4121 acl relating,defects
R1202 T4245 T4242 nsubj embryos,died
R1203 T4246 T4247 amod prior,to
R1204 T4131 T4130 prep to,relating
R1205 T4247 T4242 prep to,died
R1206 T4248 T4249 det the,stage
R1207 T4249 T4247 pobj stage,to
R1208 T4250 T4249 compound implantation,stage
R1209 T4251 T4242 punct ", ",died
R1210 T4252 T4242 advcl indicating,died
R1211 T4132 T4133 poss their,aggregation
R1212 T4253 T4254 mark that,is
R1213 T4254 T4252 ccomp is,indicating
R1214 T4255 T4256 compound m,calpain
R1215 T4133 T4131 pobj aggregation,to
R1216 T4256 T4254 nsubj calpain,is
R1217 T4257 T4256 punct -,calpain
R1218 T4258 T4254 acomp indispensable,is
R1219 T4134 T4133 cc and,aggregation
R1220 T4259 T4258 prep for,indispensable
R1221 T4260 T4261 amod early,embryogenesis
R1222 T4261 T4259 pobj embryogenesis,for
R1223 T4135 T4136 compound clot,retraction
R1224 T4262 T4239 punct .,report
R1225 T4264 T4265 det This,role
R1226 T4136 T4133 conj retraction,aggregation
R1227 T4265 T4266 nsubjpass role,fulfilled
R1228 T4267 T4266 aux can,fulfilled
R1229 T4137 T4138 punct [,33
R1230 T4268 T4266 neg not,fulfilled
R1231 T4269 T4266 auxpass be,fulfilled
R1232 T4270 T4266 agent by,fulfilled
R1233 T4138 T4098 parataxis 33,reported
R1234 T4271 T4272 compound μ,calpain
R1235 T4272 T4270 pobj calpain,by
R1236 T4139 T4138 punct ],33
R1237 T4140 T4098 punct .,reported
R1238 T4142 T4143 det The,fact
R1239 T4273 T4272 punct -,calpain
R1240 T4274 T4272 punct ", ",calpain
R1241 T4275 T4276 dep which,expressed
R1242 T4143 T4144 nsubj fact,indicates
R1243 T4276 T4272 relcl expressed,calpain
R1244 T4277 T4276 auxpass is,expressed
R1245 T4278 T4276 prep in,expressed
R1246 T4145 T4146 mark that,die
R1247 T4279 T4280 amod embryonic,stem
R1248 T4280 T4281 nmod stem,cells
R1249 T4281 T4278 pobj cells,in
R1250 T4282 T4280 punct (,stem
R1251 T4146 T4143 acl die,fact
R1252 T4283 T4280 appos ES,stem
R1253 T4284 T4281 punct ),cells
R1254 T4285 T4286 punct [,31
R1255 T4147 T4148 npadvmod Capn4,null
R1256 T4286 T4276 parataxis 31,expressed
R1257 T4287 T4286 punct ],31
R1258 T4288 T4276 cc and,expressed
R1259 T4148 T4149 amod null,mice
R1260 T4289 T4290 auxpass is,assumed
R1261 T4290 T4276 conj assumed,expressed
R1262 T4291 T4292 aux to,be
R1263 T4292 T4290 xcomp be,assumed
R1264 T4293 T4292 acomp present,be
R1265 T4294 T4293 prep at,present
R1266 T4149 T4146 nsubj mice,die
R1270 T4150 T4146 prep during,die
R1271 T4298 T4297 pobj gestation,of
R1272 T4299 T4266 punct .,fulfilled
R1273 T4151 T4150 pobj embryogenesis,during
R1274 T4301 T4302 nsubj This,demonstrates
R1275 T4152 T4153 mark that,is
R1276 T4303 T4302 advmod unequivocally,demonstrates
R1277 T4304 T4305 mark that,have
R1278 T4305 T4302 ccomp have,demonstrates
R1279 T4153 T4144 ccomp is,indicates
R1280 T4306 T4307 compound m,calpain
R1281 T4307 T4305 nsubj calpain,have
R1282 T4308 T4307 punct -,calpain
R1283 T4154 T4155 advmod at,one
R1284 T4309 T4307 cc and,calpain
R1285 T4310 T4311 compound μ,calpain
R1286 T4311 T4307 conj calpain,calpain
R1287 T4155 T4153 nsubj one,is
R1288 T4312 T4311 punct -,calpain
R1289 T4313 T4314 amod distinct,roles
R1290 T4314 T4305 dobj roles,have
R1291 T4156 T4155 advmod least,one
R1292 T4315 T4314 amod physiological,roles
R1293 T4316 T4305 prep during,have
R1294 T4317 T4318 amod early,embryogenesis
R1295 T4157 T4155 prep of,one
R1296 T4318 T4316 pobj embryogenesis,during
R1297 T4319 T4302 punct .,demonstrates
R1298 T4158 T4159 det the,calpains
R1299 T4159 T4157 pobj calpains,of
R1300 T4160 T4159 amod ubiquitous,calpains
R1301 T4161 T4153 acomp essential,is
R1302 T4162 T4161 prep for,essential
R1303 T4163 T4162 pobj development,for
R1304 T4164 T4163 prep to,development
R1305 T4165 T4164 pobj term,to
R1306 T4166 T4144 punct .,indicates
R1307 T4833 T4832 cc and,Isolation
R1308 T4834 T4832 conj characterization,Isolation
R1309 T4835 T4832 prep of,Isolation
R1310 T4836 T4837 npadvmod Capn2,targeted
R1313 T4839 T4840 compound ES,cell
R1059 T4075 T4074 prep to,survival
R1070 T4081 T4079 nsubj mice,represented
R1267 T4295 T4296 det this,stage
R1268 T4296 T4294 pobj stage,at
R1269 T4297 T4296 prep of,stage

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2980 20-37 CHEBI:82824 denotes calpain inhibitor
T2981 67-72 CHEBI:29917 denotes thiol
T2982 162-175 GO:0008283 denotes proliferation
T2983 213-223 GO:0010467 denotes expression
T2984 330-334 SO:0000704 denotes gene
T2985 347-351 NCBITaxon:10088 denotes mice
T2986 478-485 SO:0001060 denotes isoform
T2987 531-536 PR:000005022 denotes Capn4
T2988 644-649 PR:000005022 denotes Capn4
T2989 653-659 NCBITaxon:39107 denotes murine
T2990 660-667 UBERON:0000922 denotes embryos
T2991 668-672 GO:0016265 denotes died
T2992 699-708 GO:0007565 denotes gestation
T2993 783-790 UBERON:0000922 denotes embryos
T2994 797-802 PR:000005022 denotes Capn4
T2995 806-812 NCBITaxon:39107 denotes murine
T2996 813-822 UBERON:0000922 denotes embryonic
T2997 823-834 CL:0000057 denotes fibroblasts
T2998 871-878 UBERON:0000922 denotes embryos
T2999 1109-1124 GO:0005925 denotes focal adhesions
T3000 1155-1160 PR:000005022 denotes Capn4
T3001 1214-1218 SO:0000704 denotes gene
T3002 1243-1252 UBERON:0000922 denotes embryonic
T3003 1284-1296 GO:0007566 denotes implantation
T3004 1332-1341 UBERON:0000922 denotes embryonic
T3005 1386-1391 PR:000005022 denotes Capn4
T3006 1395-1399 NCBITaxon:10088 denotes mice
T3007 1536-1545 GO:0007565 denotes gestation
T3008 1573-1578 PR:000005022 denotes Capn4
T3009 1582-1586 NCBITaxon:10088 denotes mice
T3010 1640-1645 PR:000005009 denotes Capn1
T3011 1660-1687 PR:000005009 denotes μ-calpain catalytic subunit
T3012 1744-1748 NCBITaxon:10088 denotes mice
T3013 1794-1803 CL:0000233 denotes platelets
T3014 1874-1879 PR:000005022 denotes Capn4
T3015 1885-1889 NCBITaxon:10088 denotes mice
T3016 1890-1893 GO:0016265 denotes die
T3017 1901-1914 GO:0009790 denotes embryogenesis
T3018 2025-2030 PR:000005009 denotes Capn1
T3019 2041-2045 NCBITaxon:10088 denotes mice
T3020 2156-2169 GO:0009790 denotes embryogenesis
T3021 2325-2330 PR:000005015 denotes Capn2
T3022 2331-2335 SO:0000704 denotes gene
T3023 2349-2363 PR:000005015 denotes m-80 k subunit
T3024 2367-2371 NCBITaxon:10088 denotes mice
T3025 2393-2398 PR:000005015 denotes Capn2
T3026 2404-2411 UBERON:0000922 denotes embryos
T3027 2412-2416 GO:0016265 denotes died
T3028 2430-2442 GO:0007566 denotes implantation
T3029 2503-2516 GO:0009790 denotes embryogenesis
T3030 2571-2580 GO:0010467 denotes expressed
T3031 2584-2593 UBERON:0000922 denotes embryonic
T3032 2584-2598 _FRAGMENT denotes embryonic stem
T3033 2604-2609 CL:0002322 denotes cells
T3034 2600-2602 _FRAGMENT denotes ES
T3035 2661-2670 GO:0007565 denotes gestation
T3036 2780-2793 GO:0009790 denotes embryogenesis
T4751 2839-2844 PR:000005015 denotes Capn2
T4752 2854-2861 CL:0002322 denotes ES cell
R273 T3033 T3032 _lexicallyChainedTo cells,embryonic stem
R276 T3033 T3034 _lexicallyChainedTo cells,ES

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3136 5-9 CL_GO_EXT:cell denotes cell
T3137 20-37 CHEBI_EXT:82824 denotes calpain inhibitor
T3138 67-72 CHEBI:29917 denotes thiol
T3139 67-82 GO_EXT:0008234 denotes thiol-proteases
T3140 116-121 CL_GO_EXT:cell denotes cells
T3141 130-139 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3142 162-175 GO:0008283 denotes proliferation
T3143 203-212 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3144 213-223 GO:0010467 denotes expression
T3145 243-248 CL_GO_EXT:cell denotes cells
T3146 287-296 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3147 301-305 CL_GO_EXT:cell denotes cell
T3148 330-334 SO_EXT:0000704 denotes gene
T3149 335-343 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3150 347-351 NCBITaxon:10088 denotes mice
T3151 400-413 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T3152 423-425 _FRAGMENT denotes μ-
T3153 432-439 GO_PR_EXT:calpain_1_complex denotes calpain
T3154 430-439 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3155 478-485 SO_EXT:0001060 denotes isoform
T3156 531-536 PR_EXT:000005022 denotes Capn4
T3157 626-628 _FRAGMENT denotes μ-
T3158 635-642 GO_PR_EXT:calpain_1_complex denotes calpain
T3159 633-642 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3160 644-649 PR_EXT:000005022 denotes Capn4
T3161 649-650 SO_EXT:sequence_nullness_or_absence denotes -
T3162 651-652 SO_EXT:sequence_nullness_or_absence denotes -
T3163 653-659 NCBITaxon:39107 denotes murine
T3164 660-667 UBERON:0000922 denotes embryos
T3165 668-672 GO:0016265 denotes died
T3166 699-708 GO:0007565 denotes gestation
T3167 738-740 _FRAGMENT denotes μ-
T3168 746-753 GO_PR_EXT:calpain_1_complex denotes calpain
T3169 744-753 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3170 783-790 UBERON:0000922 denotes embryos
T3171 797-802 PR_EXT:000005022 denotes Capn4
T3172 802-803 SO_EXT:sequence_nullness_or_absence denotes -
T3173 804-805 SO_EXT:sequence_nullness_or_absence denotes -
T3174 806-812 NCBITaxon:39107 denotes murine
T3175 813-822 UBERON:0000922 denotes embryonic
T3176 823-834 CL:0000057 denotes fibroblasts
T3177 871-878 UBERON:0000922 denotes embryos
T3178 994-1002 GO_PR_EXT:spectrin denotes spectrin
T3179 1042-1051 GO_EXT:biological_movement_or_translocation_process denotes migration
T3180 1098-1105 GO_EXT:biological_release denotes release
T3181 1109-1124 GO:0005925 denotes focal adhesions
T3182 1115-1124 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesions
T3183 1155-1160 PR_EXT:000005022 denotes Capn4
T3184 1198-1206 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3185 1214-1218 SO_EXT:0000704 denotes gene
T3186 1243-1252 UBERON:0000922 denotes embryonic
T3187 1253-1262 GO_EXT:fatality_or_lethality denotes lethality
T3188 1284-1296 GO:0007566 denotes implantation
T3189 1332-1341 UBERON:0000922 denotes embryonic
T3190 1342-1351 GO_EXT:fatality_or_lethality denotes lethality
T3191 1386-1391 PR_EXT:000005022 denotes Capn4
T3192 1391-1392 SO_EXT:sequence_nullness_or_absence denotes -
T3193 1393-1394 SO_EXT:sequence_nullness_or_absence denotes -
T3194 1395-1399 NCBITaxon:10088 denotes mice
T3195 1438-1446 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3196 1536-1545 GO:0007565 denotes gestation
T3197 1573-1578 PR_EXT:000005022 denotes Capn4
T3198 1578-1579 SO_EXT:sequence_nullness_or_absence denotes -
T3199 1580-1581 SO_EXT:sequence_nullness_or_absence denotes -
T3200 1582-1586 NCBITaxon:10088 denotes mice
T3201 1611-1615 SO_EXT:sequence_nullness denotes null
T3202 1616-1624 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3203 1640-1645 PR_EXT:000005009 denotes Capn1
T3204 1647-1655 SO_EXT:sequence_coding_function denotes encoding
T3205 1660-1669 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3206 1660-1687 PR_EXT:000005009 denotes μ-calpain catalytic subunit
T3207 1670-1679 GO_MOP_EXT:catalysis denotes catalytic
T3208 1744-1748 NCBITaxon:10088 denotes mice
T3209 1779-1788 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3210 1794-1803 CL:0000233 denotes platelets
T3211 1874-1879 PR_EXT:000005022 denotes Capn4
T3212 1880-1884 SO_EXT:sequence_nullness denotes null
T3213 1885-1889 NCBITaxon:10088 denotes mice
T3214 1890-1893 GO:0016265 denotes die
T3215 1901-1914 GO:0009790 denotes embryogenesis
T3216 2025-2030 PR_EXT:000005009 denotes Capn1
T3217 2041-2045 NCBITaxon:10088 denotes mice
T3218 2114-2123 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3219 2156-2169 GO:0009790 denotes embryogenesis
T3220 2325-2330 PR_EXT:000005015 denotes Capn2
T3221 2331-2335 SO_EXT:0000704 denotes gene
T3222 2336-2344 SO_EXT:sequence_coding_function denotes encoding
T3223 2349-2363 PR_EXT:000005015 denotes m-80 k subunit
T3224 2367-2371 NCBITaxon:10088 denotes mice
T3225 2393-2398 PR_EXT:000005015 denotes Capn2
T3226 2399-2403 SO_EXT:sequence_nullness denotes null
T3227 2404-2411 UBERON:0000922 denotes embryos
T3228 2412-2416 GO:0016265 denotes died
T3229 2430-2442 GO:0007566 denotes implantation
T3230 2466-2475 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3231 2503-2516 GO:0009790 denotes embryogenesis
T3232 2551-2560 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3233 2571-2580 GO:0010467 denotes expressed
T3234 2584-2593 UBERON:0000922 denotes embryonic
T3235 2584-2598 _FRAGMENT denotes embryonic stem
T3236 2604-2609 CL:0002322 denotes cells
T3237 2600-2602 _FRAGMENT denotes ES
T3238 2604-2609 CL_GO_EXT:cell denotes cells
T3239 2661-2670 GO:0007565 denotes gestation
T3240 2709-2718 GO_PR_EXT:calpain_2_complex denotes m-calpain
T3241 2723-2732 GO_PR_EXT:calpain_1_complex denotes μ-calpain
T3242 2747-2760 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T3243 2780-2793 GO:0009790 denotes embryogenesis
T4774 2839-2844 PR_EXT:000005015 denotes Capn2
T4775 2854-2861 CL:0002322 denotes ES cell
T4776 2857-2861 CL_GO_EXT:cell denotes cell
R277 T3153 T3152 _lexicallyChainedTo calpain,μ-
R280 T3158 T3157 _lexicallyChainedTo calpain,μ-
R281 T3168 T3167 _lexicallyChainedTo calpain,μ-
R285 T3236 T3235 _lexicallyChainedTo cells,embryonic stem
R286 T3236 T3237 _lexicallyChainedTo cells,ES