PMC:1382200 / 288-634 JSONTXT

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    craft-sa-dev

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of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. 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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T541","span":{"begin":47,"end":52},"obj":"PR:000005009"},{"id":"T542","span":{"begin":68,"end":73},"obj":"PR:000005015"},{"id":"T543","span":{"begin":100,"end":110},"obj":"GO:0065007"},{"id":"T544","span":{"begin":130,"end":135},"obj":"PR:000005022"},{"id":"T545","span":{"begin":155,"end":160},"obj":"NCBITaxon:10088"},{"id":"T546","span":{"begin":161,"end":166},"obj":"PR:000005022"},{"id":"T547","span":{"begin":167,"end":171},"obj":"SO:0000704"},{"id":"T548","span":{"begin":237,"end":246},"obj":"UBERON:0000922"},{"id":"T549","span":{"begin":333,"end":342},"obj":"NCBITaxon:40674"}],"text":"sed of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. Disruption of the mouse Capn4 gene abolished both μ-calpain and m-calpain activity, and resulted in embryonic lethality, thereby suggesting essential roles for one or both of these enzymes during mammalian emb"}

    craft-ca-core-ex-dev

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