Figure 6  The Effects of Sex on Trans-eQTL Correlated with Gonadal Fat Mass
(A) Example of the effect of genotype at a trans locus on gene expression. Presence of homozygous B6 (BB), C3H (CC), or heterozygous (BC) genotype at a trans locus affects transcript MMT00016118 levels (reported as mlratio) in a sex-specific manner, with effects detectable only in females. Coefficients of determination (R 2, or proportion variance explained) are shown along with associated ANOVA p-values. Several trans-eQTLs correlated with gonadal fat mass localize to regions overlapping with cQTLs for this trait, specifically, to Chromosome 19, 40 cM.
(B) For Chromosome 19, the vast majority of these correlated trans-eQTLs are biased toward larger effects on gene expression in females (red lines). The effect of any given trans-eQTL is approximated as R 2 determined in a manner similar to that depicted in (A).