of bone was lost over the same timeframe. Table 2 Morphology and Bone Mineral Density in 4- and 12-Month-Old Female Mice Figure 3 Radiologic Assessment of the Femur of Young and Old Sam68+/+ and Sam68−/− Mice (A) Mice were given a lethal dose of anesthetic at the indicated times, and contact radiographs of the distal femora were obtained on a Faxitron MX20 equipped with an FPX-2 Imaging system. Representative radiogra