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Herein we report the generation of Sam68-null mice by homologous recombination. Aged Sam68−/− mice preserved their bone mass, in sharp contrast with 12-month-old wild-type littermates in which bone mass was decreased up to approximately 75%. In fact, the bone volume of the 12-month-old Sam68−/− mice was virtually indistinguishable from that of 4-month-old wild-type or Sam68−/− mice. Sam68−/− bone marrow s"}

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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T123","span":{"begin":16,"end":21},"obj":"PR_EXT:000009279"},{"id":"T124","span":{"begin":22,"end":25},"obj":"CHEBI_SO_EXT:RNA"},{"id":"T125","span":{"begin":26,"end":33},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T126","span":{"begin":34,"end":41},"obj":"CHEBI_PR_EXT:protein"},{"id":"T127","span":{"begin":51,"end":55},"obj":"NCBITaxon:10088"},{"id":"T128","span":{"begin":73,"end":77},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T129","span":{"begin":140,"end":185},"obj":"PR_EXT:000009279"},{"id":"T130","span":{"begin":168,"end":175},"obj":"GO:0007067"},{"id":"T131","span":{"begin":187,"end":192},"obj":"PR_EXT:000009279"},{"id":"T132","span":{"begin":207,"end":210},"obj":"CHEBI_SO_EXT:RNA"},{"id":"T133","span":{"begin":211,"end":218},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T134","span":{"begin":219,"end":226},"obj":"CHEBI_PR_EXT:protein"},{"id":"T135","span":{"begin":250,"end":258},"obj":"GO:0065007"},{"id":"T136","span":{"begin":278,"end":281},"obj":"CHEBI_SO_EXT:RNA"},{"id":"T137","span":{"begin":278,"end":292},"obj":"GO:0016070"},{"id":"T138","span":{"begin":307,"end":318},"obj":"GO_PATO_EXT:physiological_process_or_quality"},{"id":"T139","span":{"begin":381,"end":386},"obj":"PR_EXT:000009279"},{"id":"T140","span":{"begin":387,"end":391},"obj":"SO_EXT:sequence_nullness"},{"id":"T141","span":{"begin":392,"end":396},"obj":"NCBITaxon:10088"},{"id":"T142","span":{"begin":411,"end":424},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T143","span":{"begin":426,"end":430},"obj":"GO_PATO_EXT:aging_or_agedness"},{"id":"T144","span":{"begin":431,"end":436},"obj":"PR_EXT:000009279"},{"id":"T145","span":{"begin":436,"end":437},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T146","span":{"begin":438,"end":439},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T147","span":{"begin":440,"end":444},"obj":"NCBITaxon:10088"},{"id":"T148","span":{"begin":461,"end":465},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T149","span":{"begin":508,"end":517},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T150","span":{"begin":539,"end":543},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T151","span":{"begin":601,"end":605},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T152","span":{"begin":633,"end":638},"obj":"PR_EXT:000009279"},{"id":"T153","span":{"begin":638,"end":639},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T154","span":{"begin":640,"end":641},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T155","span":{"begin":642,"end":646},"obj":"NCBITaxon:10088"},{"id":"T156","span":{"begin":704,"end":713},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T157","span":{"begin":717,"end":722},"obj":"PR_EXT:000009279"},{"id":"T158","span":{"begin":722,"end":723},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T159","span":{"begin":724,"end":725},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T160","span":{"begin":726,"end":730},"obj":"NCBITaxon:10088"},{"id":"T161","span":{"begin":732,"end":737},"obj":"PR_EXT:000009279"},{"id":"T162","span":{"begin":737,"end":738},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T163","span":{"begin":739,"end":740},"obj":"SO_EXT:sequence_nullness_or_absence"}],"text":"Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss\nSam68 Regulates Osteogenesis and Bone Mass\n\nAbstract\nThe Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism; however, its physiologic role has remained elusive. Herein we report the generation of Sam68-null mice by homologous recombination. Aged Sam68−/− mice preserved their bone mass, in sharp contrast with 12-month-old wild-type littermates in which bone mass was decreased up to approximately 75%. In fact, the bone volume of the 12-month-old Sam68−/− mice was virtually indistinguishable from that of 4-month-old wild-type or Sam68−/− mice. Sam68−/− bone marrow s"}