Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss Sam68 Regulates Osteogenesis and Bone Mass Abstract The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism; however, its physiologic role has remained elusive. Herein we report the gener