DNM participated in the design of the study, performed the TF identification, carried out TA measurements, coordinated and participated in the statistical analysis and drafted the manuscript. ELC contributed the preliminary data, participated in the design of the study and carried out TA measurements. SAK performed the statistical analysis for interpretation of data. DAH and YY consented patients and obtained the primary samples necessary for the study according to IRB regulations. JCW conceived of the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.