PMC:1283364 / 41056-41373 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1283364","sourcedb":"PMC","sourceid":"1283364","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1283364","text":" In fact, levels of PBS-soluble Aβ40 and Aβ42 in the 6 mo + 3 mo and 6 mo + 6 mo treated cohorts were most similar to that of the 9 mo untreated cohort, suggesting that age, as opposed to synthetic rate (which would be negligible in the treated animals), may determine the fraction of PBS-soluble Aβ in these animals.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T9021","span":{"begin":0,"end":317},"obj":"sentence"},{"id":"T9022","span":{"begin":1,"end":3},"obj":"IN"},{"id":"T9023","span":{"begin":97,"end":101},"obj":"VBD"},{"id":"T9024","span":{"begin":4,"end":8},"obj":"NN"},{"id":"T9025","span":{"begin":8,"end":10},"obj":","},{"id":"T9026","span":{"begin":10,"end":16},"obj":"NNS"},{"id":"T9027","span":{"begin":17,"end":19},"obj":"IN"},{"id":"T9028","span":{"begin":20,"end":23},"obj":"NN"},{"id":"T9029","span":{"begin":24,"end":31},"obj":"JJ"},{"id":"T9030","span":{"begin":23,"end":24},"obj":"HYPH"},{"id":"T9031","span":{"begin":32,"end":36},"obj":"NN"},{"id":"T9032","span":{"begin":37,"end":40},"obj":"CC"},{"id":"T9033","span":{"begin":41,"end":45},"obj":"NN"},{"id":"T9034","span":{"begin":46,"end":48},"obj":"IN"},{"id":"T9035","span":{"begin":49,"end":52},"obj":"DT"},{"id":"T9036","span":{"begin":89,"end":96},"obj":"NNS"},{"id":"T9037","span":{"begin":53,"end":54},"obj":"CD"},{"id":"T9038","span":{"begin":55,"end":57},"obj":"NN"},{"id":"T9039","span":{"begin":58,"end":59},"obj":"SYM"},{"id":"T9040","span":{"begin":60,"end":61},"obj":"CD"},{"id":"T9041","span":{"begin":62,"end":64},"obj":"NN"},{"id":"T9042","span":{"begin":65,"end":68},"obj":"CC"},{"id":"T9043","span":{"begin":69,"end":70},"obj":"CD"},{"id":"T9044","span":{"begin":71,"end":73},"obj":"NN"},{"id":"T9045","span":{"begin":74,"end":75},"obj":"SYM"},{"id":"T9046","span":{"begin":76,"end":77},"obj":"CD"},{"id":"T9047","span":{"begin":78,"end":80},"obj":"NN"},{"id":"T9048","span":{"begin":81,"end":88},"obj":"VBN"},{"id":"T9049","span":{"begin":102,"end":106},"obj":"RBS"},{"id":"T9050","span":{"begin":107,"end":114},"obj":"JJ"},{"id":"T9051","span":{"begin":115,"end":117},"obj":"IN"},{"id":"T9052","span":{"begin":118,"end":122},"obj":"DT"},{"id":"T9053","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T9054","span":{"begin":126,"end":129},"obj":"DT"},{"id":"T9055","span":{"begin":145,"end":151},"obj":"NN"},{"id":"T9056","span":{"begin":130,"end":131},"obj":"CD"},{"id":"T9057","span":{"begin":132,"end":134},"obj":"NN"},{"id":"T9058","span":{"begin":135,"end":144},"obj":"JJ"},{"id":"T9059","span":{"begin":151,"end":153},"obj":","},{"id":"T9060","span":{"begin":153,"end":163},"obj":"VBG"},{"id":"T9061","span":{"begin":164,"end":168},"obj":"IN"},{"id":"T9062","span":{"begin":259,"end":268},"obj":"VB"},{"id":"T9063","span":{"begin":169,"end":172},"obj":"NN"},{"id":"T9064","span":{"begin":172,"end":174},"obj":","},{"id":"T9065","span":{"begin":174,"end":176},"obj":"IN"},{"id":"T9066","span":{"begin":177,"end":184},"obj":"VBN"},{"id":"T9067","span":{"begin":185,"end":187},"obj":"IN"},{"id":"T9068","span":{"begin":188,"end":197},"obj":"JJ"},{"id":"T9069","span":{"begin":198,"end":202},"obj":"NN"},{"id":"T9070","span":{"begin":203,"end":204},"obj":"-LRB-"},{"id":"T9071","span":{"begin":204,"end":209},"obj":"WDT"},{"id":"T9072","span":{"begin":216,"end":218},"obj":"VB"},{"id":"T9073","span":{"begin":210,"end":215},"obj":"MD"},{"id":"T9074","span":{"begin":219,"end":229},"obj":"JJ"},{"id":"T9075","span":{"begin":230,"end":232},"obj":"IN"},{"id":"T9076","span":{"begin":233,"end":236},"obj":"DT"},{"id":"T9077","span":{"begin":245,"end":252},"obj":"NNS"},{"id":"T9078","span":{"begin":237,"end":244},"obj":"VBN"},{"id":"T9079","span":{"begin":252,"end":253},"obj":"-RRB-"},{"id":"T9080","span":{"begin":253,"end":255},"obj":","},{"id":"T9081","span":{"begin":255,"end":258},"obj":"MD"},{"id":"T9082","span":{"begin":269,"end":272},"obj":"DT"},{"id":"T9083","span":{"begin":273,"end":281},"obj":"NN"},{"id":"T9084","span":{"begin":282,"end":284},"obj":"IN"},{"id":"T9085","span":{"begin":285,"end":288},"obj":"NN"},{"id":"T9086","span":{"begin":289,"end":296},"obj":"JJ"},{"id":"T9087","span":{"begin":288,"end":289},"obj":"HYPH"},{"id":"T9088","span":{"begin":297,"end":299},"obj":"NN"},{"id":"T9089","span":{"begin":300,"end":302},"obj":"IN"},{"id":"T9090","span":{"begin":303,"end":308},"obj":"DT"},{"id":"T9091","span":{"begin":309,"end":316},"obj":"NNS"},{"id":"T9092","span":{"begin":316,"end":317},"obj":"."}],"relations":[{"id":"R6296","pred":"prep","subj":"T9022","obj":"T9023"},{"id":"R6298","pred":"pobj","subj":"T9024","obj":"T9022"},{"id":"R6300","pred":"punct","subj":"T9025","obj":"T9023"},{"id":"R6301","pred":"nsubj","subj":"T9026","obj":"T9023"},{"id":"R6303","pred":"prep","subj":"T9027","obj":"T9026"},{"id":"R6304","pred":"npadvmod","subj":"T9028","obj":"T9029"},{"id":"R6305","pred":"amod","subj":"T9029","obj":"T9031"},{"id":"R6307","pred":"punct","subj":"T9030","obj":"T9029"},{"id":"R6308","pred":"pobj","subj":"T9031","obj":"T9027"},{"id":"R6310","pred":"cc","subj":"T9032","obj":"T9031"},{"id":"R6311","pred":"conj","subj":"T9033","obj":"T9031"},{"id":"R6312","pred":"prep","subj":"T9034","obj":"T9026"},{"id":"R6314","pred":"det","subj":"T9035","obj":"T9036"},{"id":"R6315","pred":"pobj","subj":"T9036","obj":"T9034"},{"id":"R6317","pred":"nummod","subj":"T9037","obj":"T9038"},{"id":"R6318","pred":"nmod","subj":"T9038","obj":"T9036"},{"id":"R6319","pred":"punct","subj":"T9039","obj":"T9038"},{"id":"R6321","pred":"nummod","subj":"T9040","obj":"T9041"},{"id":"R6322","pred":"appos","subj":"T9041","obj":"T9038"},{"id":"R6324","pred":"cc","subj":"T9042","obj":"T9038"},{"id":"R6325","pred":"nummod","subj":"T9043","obj":"T9044"},{"id":"R6326","pred":"conj","subj":"T9044","obj":"T9038"},{"id":"R6328","pred":"punct","subj":"T9045","obj":"T9044"},{"id":"R6329","pred":"nummod","subj":"T9046","obj":"T9047"},{"id":"R6330","pred":"appos","subj":"T9047","obj":"T9044"},{"id":"R6331","pred":"acl","subj":"T9048","obj":"T9044"},{"id":"R6333","pred":"advmod","subj":"T9049","obj":"T9050"},{"id":"R6334","pred":"acomp","subj":"T9050","obj":"T9023"},{"id":"R6335","pred":"prep","subj":"T9051","obj":"T9050"},{"id":"R6338","pred":"pobj","subj":"T9052","obj":"T9051"},{"id":"R6339","pred":"prep","subj":"T9053","obj":"T9052"},{"id":"R6341","pred":"det","subj":"T9054","obj":"T9055"},{"id":"R6342","pred":"pobj","subj":"T9055","obj":"T9053"},{"id":"R6343","pred":"nummod","subj":"T9056","obj":"T9057"},{"id":"R6345","pred":"nmod","subj":"T9057","obj":"T9055"},{"id":"R6346","pred":"amod","subj":"T9058","obj":"T9055"},{"id":"R6348","pred":"punct","subj":"T9059","obj":"T9023"},{"id":"R6349","pred":"advcl","subj":"T9060","obj":"T9023"},{"id":"R6351","pred":"mark","subj":"T9061","obj":"T9062"},{"id":"R6352","pred":"ccomp","subj":"T9062","obj":"T9060"},{"id":"R6353","pred":"nsubj","subj":"T9063","obj":"T9062"},{"id":"R6354","pred":"punct","subj":"T9064","obj":"T9063"},{"id":"R6355","pred":"prep","subj":"T9065","obj":"T9063"},{"id":"R6356","pred":"prep","subj":"T9066","obj":"T9065"},{"id":"R6358","pred":"prep","subj":"T9067","obj":"T9066"},{"id":"R6359","pred":"amod","subj":"T9068","obj":"T9069"},{"id":"R6361","pred":"pobj","subj":"T9069","obj":"T9067"},{"id":"R6362","pred":"punct","subj":"T9070","obj":"T9069"},{"id":"R6363","pred":"dep","subj":"T9071","obj":"T9072"},{"id":"R6365","pred":"relcl","subj":"T9072","obj":"T9069"},{"id":"R6366","pred":"aux","subj":"T9073","obj":"T9072"},{"id":"R6368","pred":"acomp","subj":"T9074","obj":"T9072"},{"id":"R6369","pred":"prep","subj":"T9075","obj":"T9072"},{"id":"R6370","pred":"det","subj":"T9076","obj":"T9077"},{"id":"R6372","pred":"pobj","subj":"T9077","obj":"T9075"},{"id":"R6373","pred":"amod","subj":"T9078","obj":"T9077"},{"id":"R6374","pred":"punct","subj":"T9079","obj":"T9062"},{"id":"R6376","pred":"punct","subj":"T9080","obj":"T9062"},{"id":"R6377","pred":"aux","subj":"T9081","obj":"T9062"},{"id":"R6378","pred":"det","subj":"T9082","obj":"T9083"},{"id":"R6380","pred":"dobj","subj":"T9083","obj":"T9062"},{"id":"R6381","pred":"prep","subj":"T9084","obj":"T9083"},{"id":"R6383","pred":"npadvmod","subj":"T9085","obj":"T9086"},{"id":"R6384","pred":"amod","subj":"T9086","obj":"T9088"},{"id":"R6385","pred":"punct","subj":"T9087","obj":"T9086"},{"id":"R6387","pred":"pobj","subj":"T9088","obj":"T9084"},{"id":"R6388","pred":"prep","subj":"T9089","obj":"T9062"},{"id":"R6389","pred":"det","subj":"T9090","obj":"T9091"},{"id":"R6391","pred":"pobj","subj":"T9091","obj":"T9089"},{"id":"R6392","pred":"punct","subj":"T9092","obj":"T9023"}],"attributes":[{"subj":"T9021","pred":"source","obj":"craft-sa-dev"},{"subj":"T9022","pred":"source","obj":"craft-sa-dev"},{"subj":"T9023","pred":"source","obj":"craft-sa-dev"},{"subj":"T9024","pred":"source","obj":"craft-sa-dev"},{"subj":"T9025","pred":"source","obj":"craft-sa-dev"},{"subj":"T9026","pred":"source","obj":"craft-sa-dev"},{"subj":"T9027","pred":"source","obj":"craft-sa-dev"},{"subj":"T9028","pred":"source","obj":"craft-sa-dev"},{"subj":"T9029","pred":"source","obj":"craft-sa-dev"},{"subj":"T9030","pred":"source","obj":"craft-sa-dev"},{"subj":"T9031","pred":"source","obj":"craft-sa-dev"},{"subj":"T9032","pred":"source","obj":"craft-sa-dev"},{"subj":"T9033","pred":"source","obj":"craft-sa-dev"},{"subj":"T9034","pred":"source","obj":"craft-sa-dev"},{"subj":"T9035","pred":"source","obj":"craft-sa-dev"},{"subj":"T9036","pred":"source","obj":"craft-sa-dev"},{"subj":"T9037","pred":"source","obj":"craft-sa-dev"},{"subj":"T9038","pred":"source","obj":"craft-sa-dev"},{"subj":"T9039","pred":"source","obj":"craft-sa-dev"},{"subj":"T9040","pred":"source","obj":"craft-sa-dev"},{"subj":"T9041","pred":"source","obj":"craft-sa-dev"},{"subj":"T9042","pred":"source","obj":"craft-sa-dev"},{"subj":"T9043","pred":"source","obj":"craft-sa-dev"},{"subj":"T9044","pred":"source","obj":"craft-sa-dev"},{"subj":"T9045","pred":"source","obj":"craft-sa-dev"},{"subj":"T9046","pred":"source","obj":"craft-sa-dev"},{"subj":"T9047","pred":"source","obj":"craft-sa-dev"},{"subj":"T9048","pred":"source","obj":"craft-sa-dev"},{"subj":"T9049","pred":"source","obj":"craft-sa-dev"},{"subj":"T9050","pred":"source","obj":"craft-sa-dev"},{"subj":"T9051","pred":"source","obj":"craft-sa-dev"},{"subj":"T9052","pred":"source","obj":"craft-sa-dev"},{"subj":"T9053","pred":"source","obj":"craft-sa-dev"},{"subj":"T9054","pred":"source","obj":"craft-sa-dev"},{"subj":"T9055","pred":"source","obj":"craft-sa-dev"},{"subj":"T9056","pred":"source","obj":"craft-sa-dev"},{"subj":"T9057","pred":"source","obj":"craft-sa-dev"},{"subj":"T9058","pred":"source","obj":"craft-sa-dev"},{"subj":"T9059","pred":"source","obj":"craft-sa-dev"},{"subj":"T9060","pred":"source","obj":"craft-sa-dev"},{"subj":"T9061","pred":"source","obj":"craft-sa-dev"},{"subj":"T9062","pred":"source","obj":"craft-sa-dev"},{"subj":"T9063","pred":"source","obj":"craft-sa-dev"},{"subj":"T9064","pred":"source","obj":"craft-sa-dev"},{"subj":"T9065","pred":"source","obj":"craft-sa-dev"},{"subj":"T9066","pred":"source","obj":"craft-sa-dev"},{"subj":"T9067","pred":"source","obj":"craft-sa-dev"},{"subj":"T9068","pred":"source","obj":"craft-sa-dev"},{"subj":"T9069","pred":"source","obj":"craft-sa-dev"},{"subj":"T9070","pred":"source","obj":"craft-sa-dev"},{"subj":"T9071","pred":"source","obj":"craft-sa-dev"},{"subj":"T9072","pred":"source","obj":"craft-sa-dev"},{"subj":"T9073","pred":"source","obj":"craft-sa-dev"},{"subj":"T9074","pred":"source","obj":"craft-sa-dev"},{"subj":"T9075","pred":"source","obj":"craft-sa-dev"},{"subj":"T9076","pred":"source","obj":"craft-sa-dev"},{"subj":"T9077","pred":"source","obj":"craft-sa-dev"},{"subj":"T9078","pred":"source","obj":"craft-sa-dev"},{"subj":"T9079","pred":"source","obj":"craft-sa-dev"},{"subj":"T9080","pred":"source","obj":"craft-sa-dev"},{"subj":"T9081","pred":"source","obj":"craft-sa-dev"},{"subj":"T9082","pred":"source","obj":"craft-sa-dev"},{"subj":"T9083","pred":"source","obj":"craft-sa-dev"},{"subj":"T9084","pred":"source","obj":"craft-sa-dev"},{"subj":"T9085","pred":"source","obj":"craft-sa-dev"},{"subj":"T9086","pred":"source","obj":"craft-sa-dev"},{"subj":"T9087","pred":"source","obj":"craft-sa-dev"},{"subj":"T9088","pred":"source","obj":"craft-sa-dev"},{"subj":"T9089","pred":"source","obj":"craft-sa-dev"},{"subj":"T9090","pred":"source","obj":"craft-sa-dev"},{"subj":"T9091","pred":"source","obj":"craft-sa-dev"},{"subj":"T9092","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6437","span":{"begin":32,"end":36},"obj":"CHEBI_PR_EXT:amyloid_beta_40"},{"id":"T6438","span":{"begin":41,"end":45},"obj":"CHEBI_PR_EXT:amyloid_beta_42"},{"id":"T6439","span":{"begin":245,"end":252},"obj":"NCBITaxon:33208"},{"id":"T6440","span":{"begin":297,"end":299},"obj":"CHEBI_PR_EXT:amyloid_beta"},{"id":"T6441","span":{"begin":309,"end":316},"obj":"NCBITaxon:33208"}],"attributes":[{"subj":"T6437","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6438","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6439","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6440","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6441","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T6061","span":{"begin":245,"end":252},"obj":"NCBITaxon:33208"},{"id":"T6062","span":{"begin":309,"end":316},"obj":"NCBITaxon:33208"}],"attributes":[{"subj":"T6061","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T6062","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ecbb93","default":true},{"id":"craft-ca-core-ex-dev","color":"#a193ec"},{"id":"craft-ca-core-dev","color":"#9eec93"}]}]}}