AMPAR properties were altered specifically in neurons of forebrain areas, most notably olfactory bulb, olfactory cortex, and other cortical areas and hippocampus, leading to enhanced odor discrimination and learning. Interestingly, transgenic expression of GFPGluR-B in GluR-BΔFB mice (genetic “rescue”), specifically in piriform cortex and hippocampus with no detectable expression in the olfactory bulb, did not alter enhanced discrimination and learning capabilities. This is consistent with a primary role of the olfactory bulb in olfactory discrimination and learning. Alternatively, transgenic protein levels might have been too low to alter discrimination and learning capabilities, although memory was clearly affected. This notion will be further tested in mice with piriform cortex-specific GluR-B ablation.