The effect of selective GluR-B depletion in mice indicated that GluR-B-containing AMPARs in the hippocampus, and/or (olfactory) cortex are likely to be important for olfactory memory. The olfactory memory phenotype could be due to depletion of GluR-B in olfactory cortex or hippocampus; enhanced learning and discrimination capabilities might rather be evoked by AMPARs lacking GluR-B in the olfactory bulb.