Id |
Subject |
Object |
Predicate |
Lexical cue |
T10117 |
0-5 |
NN |
denotes |
Ndrg1 |
T10118 |
49-54 |
VBN |
denotes |
named |
T10119 |
5-7 |
, |
denotes |
, |
T10120 |
7-14 |
DT |
denotes |
another |
T10121 |
40-44 |
NN |
denotes |
gene |
T10122 |
15-26 |
JJ |
denotes |
interesting |
T10123 |
27-30 |
NN |
denotes |
MTF |
T10124 |
30-31 |
HYPH |
denotes |
- |
T10125 |
31-32 |
CD |
denotes |
1 |
T10126 |
33-39 |
NN |
denotes |
target |
T10127 |
45-48 |
VBD |
denotes |
was |
T10128 |
55-56 |
NN |
denotes |
N |
T10129 |
57-60 |
NN |
denotes |
myc |
T10130 |
56-57 |
HYPH |
denotes |
- |
T10131 |
82-86 |
NN |
denotes |
gene |
T10132 |
61-71 |
RB |
denotes |
downstream |
T10133 |
72-81 |
VBN |
denotes |
regulated |
T10134 |
87-88 |
CD |
denotes |
1 |
T10135 |
89-98 |
VBG |
denotes |
following |
T10136 |
99-102 |
DT |
denotes |
the |
T10137 |
103-112 |
NN |
denotes |
discovery |
T10138 |
113-117 |
IN |
denotes |
that |
T10139 |
149-158 |
VBZ |
denotes |
represses |
T10140 |
118-121 |
DT |
denotes |
the |
T10141 |
136-142 |
NN |
denotes |
factor |
T10142 |
122-135 |
NN |
denotes |
transcription |
T10143 |
143-144 |
NN |
denotes |
N |
T10144 |
145-148 |
NN |
denotes |
myc |
T10145 |
144-145 |
HYPH |
denotes |
- |
T10146 |
159-162 |
DT |
denotes |
the |
T10147 |
163-173 |
NN |
denotes |
expression |
T10148 |
174-176 |
IN |
denotes |
of |
T10149 |
177-182 |
NN |
denotes |
mouse |
T10150 |
183-188 |
NN |
denotes |
Ndrg1 |
T10151 |
189-190 |
-LRB- |
denotes |
( |
T10152 |
190-192 |
CD |
denotes |
51 |
T10153 |
192-193 |
-RRB- |
denotes |
) |
T10154 |
193-194 |
. |
denotes |
. |
T10155 |
194-384 |
sentence |
denotes |
Transcription of Ndrg1 and/or its human ortholog is induced by different physiological and cell stress conditions, such as androgens, nickel compounds, DNA damage and hypoxia (37–40,52,53). |
T10156 |
195-208 |
NN |
denotes |
Transcription |
T10157 |
247-254 |
VBN |
denotes |
induced |
T10158 |
209-211 |
IN |
denotes |
of |
T10159 |
212-217 |
NN |
denotes |
Ndrg1 |
T10160 |
218-221 |
CC |
denotes |
and |
T10161 |
221-222 |
HYPH |
denotes |
/ |
T10162 |
222-224 |
CC |
denotes |
or |
T10163 |
225-228 |
PRP$ |
denotes |
its |
T10164 |
235-243 |
NN |
denotes |
ortholog |
T10165 |
229-234 |
JJ |
denotes |
human |
T10166 |
244-246 |
VBZ |
denotes |
is |
T10167 |
255-257 |
IN |
denotes |
by |
T10168 |
258-267 |
JJ |
denotes |
different |
T10169 |
298-308 |
NNS |
denotes |
conditions |
T10170 |
268-281 |
JJ |
denotes |
physiological |
T10171 |
282-285 |
CC |
denotes |
and |
T10172 |
286-290 |
NN |
denotes |
cell |
T10173 |
291-297 |
NN |
denotes |
stress |
T10174 |
308-310 |
, |
denotes |
, |
T10175 |
310-314 |
JJ |
denotes |
such |
T10176 |
315-317 |
IN |
denotes |
as |
T10177 |
318-327 |
NNS |
denotes |
androgens |
T10178 |
327-329 |
, |
denotes |
, |
T10179 |
329-335 |
NN |
denotes |
nickel |
T10180 |
336-345 |
NNS |
denotes |
compounds |
T10181 |
345-347 |
, |
denotes |
, |
T10182 |
347-350 |
NN |
denotes |
DNA |
T10183 |
351-357 |
NN |
denotes |
damage |
T10184 |
358-361 |
CC |
denotes |
and |
T10185 |
362-369 |
NN |
denotes |
hypoxia |
T10186 |
370-371 |
-LRB- |
denotes |
( |
T10187 |
380-382 |
CD |
denotes |
53 |
T10188 |
371-373 |
CD |
denotes |
37 |
T10189 |
373-374 |
SYM |
denotes |
– |
T10190 |
374-376 |
CD |
denotes |
40 |
T10191 |
376-377 |
, |
denotes |
, |
T10192 |
377-379 |
CD |
denotes |
52 |
T10193 |
379-380 |
, |
denotes |
, |
T10194 |
382-383 |
-RRB- |
denotes |
) |
T10195 |
383-384 |
. |
denotes |
. |
T10196 |
384-518 |
sentence |
denotes |
In addition, the protein is overexpressed in human cancers of many tissues, such as lung, liver, brain, breast, kidney and skin (40). |
T10197 |
385-387 |
IN |
denotes |
In |
T10198 |
413-426 |
VBN |
denotes |
overexpressed |
T10199 |
388-396 |
NN |
denotes |
addition |
T10200 |
396-398 |
, |
denotes |
, |
T10201 |
398-401 |
DT |
denotes |
the |
T10202 |
402-409 |
NN |
denotes |
protein |
T10203 |
410-412 |
VBZ |
denotes |
is |
T10204 |
427-429 |
IN |
denotes |
in |
T10205 |
430-435 |
JJ |
denotes |
human |
T10206 |
436-443 |
NNS |
denotes |
cancers |
T10207 |
444-446 |
IN |
denotes |
of |
T10208 |
447-451 |
JJ |
denotes |
many |
T10209 |
452-459 |
NNS |
denotes |
tissues |
T10210 |
459-461 |
, |
denotes |
, |
T10211 |
461-465 |
JJ |
denotes |
such |
T10212 |
466-468 |
IN |
denotes |
as |
T10213 |
469-473 |
NN |
denotes |
lung |
T10214 |
473-475 |
, |
denotes |
, |
T10215 |
475-480 |
NN |
denotes |
liver |
T10216 |
480-482 |
, |
denotes |
, |
T10217 |
482-487 |
NN |
denotes |
brain |
T10218 |
487-489 |
, |
denotes |
, |
T10219 |
489-495 |
NN |
denotes |
breast |
T10220 |
495-497 |
, |
denotes |
, |
T10221 |
497-503 |
NN |
denotes |
kidney |
T10222 |
504-507 |
CC |
denotes |
and |
T10223 |
508-512 |
NN |
denotes |
skin |
T10224 |
513-514 |
-LRB- |
denotes |
( |
T10225 |
514-516 |
CD |
denotes |
40 |
T10226 |
516-517 |
-RRB- |
denotes |
) |
T10227 |
517-518 |
. |
denotes |
. |
T10228 |
518-743 |
sentence |
denotes |
Although Ndrg1 and especially its human ortholog have been quite intensely studied, its function remains unclear; however, the induction by stimuli like nickel and hypoxia suggests an involvement in the cell stress response. |
T10229 |
519-527 |
IN |
denotes |
Although |
T10230 |
594-601 |
VBN |
denotes |
studied |
T10231 |
528-533 |
NN |
denotes |
Ndrg1 |
T10232 |
534-537 |
CC |
denotes |
and |
T10233 |
538-548 |
RB |
denotes |
especially |
T10234 |
559-567 |
NN |
denotes |
ortholog |
T10235 |
549-552 |
PRP$ |
denotes |
its |
T10236 |
553-558 |
JJ |
denotes |
human |
T10237 |
568-572 |
VBP |
denotes |
have |
T10238 |
573-577 |
VBN |
denotes |
been |
T10239 |
578-583 |
RB |
denotes |
quite |
T10240 |
584-593 |
RB |
denotes |
intensely |
T10241 |
616-623 |
VBZ |
denotes |
remains |
T10242 |
601-603 |
, |
denotes |
, |
T10243 |
603-606 |
PRP$ |
denotes |
its |
T10244 |
607-615 |
NN |
denotes |
function |
T10245 |
691-699 |
VBZ |
denotes |
suggests |
T10246 |
624-631 |
JJ |
denotes |
unclear |
T10247 |
631-632 |
: |
denotes |
; |
T10248 |
633-640 |
RB |
denotes |
however |
T10249 |
640-642 |
, |
denotes |
, |
T10250 |
642-645 |
DT |
denotes |
the |
T10251 |
646-655 |
NN |
denotes |
induction |
T10252 |
656-658 |
IN |
denotes |
by |
T10253 |
659-666 |
NNS |
denotes |
stimuli |
T10254 |
667-671 |
IN |
denotes |
like |
T10255 |
672-678 |
NN |
denotes |
nickel |
T10256 |
679-682 |
CC |
denotes |
and |
T10257 |
683-690 |
NN |
denotes |
hypoxia |
T10258 |
700-702 |
DT |
denotes |
an |
T10259 |
703-714 |
NN |
denotes |
involvement |
T10260 |
715-717 |
IN |
denotes |
in |
T10261 |
718-721 |
DT |
denotes |
the |
T10262 |
734-742 |
NN |
denotes |
response |
T10263 |
722-726 |
NN |
denotes |
cell |
T10264 |
727-733 |
NN |
denotes |
stress |
T10265 |
742-743 |
. |
denotes |
. |
T10266 |
743-901 |
sentence |
denotes |
Such a role is strongly endorsed by our finding that Ndrg1 gene expression is also induced by cadmium, and that MTF-1 plays a crucial role in this induction. |
T10267 |
744-748 |
PDT |
denotes |
Such |
T10268 |
751-755 |
NN |
denotes |
role |
T10269 |
749-750 |
DT |
denotes |
a |
T10270 |
768-776 |
VBN |
denotes |
endorsed |
T10271 |
756-758 |
VBZ |
denotes |
is |
T10272 |
759-767 |
RB |
denotes |
strongly |
T10273 |
777-779 |
IN |
denotes |
by |
T10274 |
780-783 |
PRP$ |
denotes |
our |
T10275 |
784-791 |
NN |
denotes |
finding |
T10276 |
792-796 |
IN |
denotes |
that |
T10277 |
827-834 |
VBN |
denotes |
induced |
T10278 |
797-802 |
NN |
denotes |
Ndrg1 |
T10279 |
808-818 |
NN |
denotes |
expression |
T10280 |
803-807 |
NN |
denotes |
gene |
T10281 |
819-821 |
VBZ |
denotes |
is |
T10282 |
822-826 |
RB |
denotes |
also |
T10283 |
835-837 |
IN |
denotes |
by |
T10284 |
838-845 |
NN |
denotes |
cadmium |
T10285 |
845-847 |
, |
denotes |
, |
T10286 |
847-850 |
CC |
denotes |
and |
T10287 |
851-855 |
IN |
denotes |
that |
T10288 |
862-867 |
VBZ |
denotes |
plays |
T10289 |
856-859 |
NN |
denotes |
MTF |
T10290 |
859-860 |
HYPH |
denotes |
- |
T10291 |
860-861 |
CD |
denotes |
1 |
T10292 |
868-869 |
DT |
denotes |
a |
T10293 |
878-882 |
NN |
denotes |
role |
T10294 |
870-877 |
JJ |
denotes |
crucial |
T10295 |
883-885 |
IN |
denotes |
in |
T10296 |
886-890 |
DT |
denotes |
this |
T10297 |
891-900 |
NN |
denotes |
induction |
T10298 |
900-901 |
. |
denotes |
. |
R5876 |
T10117 |
T10118 |
nsubjpass |
Ndrg1,named |
R5877 |
T10119 |
T10117 |
punct |
", ",Ndrg1 |
R5878 |
T10120 |
T10121 |
det |
another,gene |
R5879 |
T10121 |
T10117 |
appos |
gene,Ndrg1 |
R5880 |
T10122 |
T10121 |
amod |
interesting,gene |
R5881 |
T10123 |
T10121 |
nmod |
MTF,gene |
R5882 |
T10124 |
T10123 |
punct |
-,MTF |
R5883 |
T10125 |
T10123 |
nummod |
1,MTF |
R5884 |
T10126 |
T10121 |
compound |
target,gene |
R5885 |
T10127 |
T10118 |
auxpass |
was,named |
R5886 |
T10128 |
T10129 |
nmod |
N,myc |
R5887 |
T10129 |
T10131 |
nmod |
myc,gene |
R5888 |
T10130 |
T10129 |
punct |
-,myc |
R5889 |
T10131 |
T10118 |
oprd |
gene,named |
R5890 |
T10132 |
T10133 |
advmod |
downstream,regulated |
R5891 |
T10133 |
T10131 |
amod |
regulated,gene |
R5892 |
T10134 |
T10131 |
nummod |
1,gene |
R5893 |
T10135 |
T10118 |
advcl |
following,named |
R5894 |
T10136 |
T10137 |
det |
the,discovery |
R5895 |
T10137 |
T10135 |
dobj |
discovery,following |
R5896 |
T10138 |
T10139 |
mark |
that,represses |
R5897 |
T10139 |
T10137 |
acl |
represses,discovery |
R5898 |
T10140 |
T10141 |
det |
the,factor |
R5899 |
T10141 |
T10139 |
nsubj |
factor,represses |
R5900 |
T10142 |
T10141 |
compound |
transcription,factor |
R5901 |
T10143 |
T10144 |
compound |
N,myc |
R5902 |
T10144 |
T10141 |
appos |
myc,factor |
R5903 |
T10145 |
T10144 |
punct |
-,myc |
R5904 |
T10146 |
T10147 |
det |
the,expression |
R5905 |
T10147 |
T10139 |
dobj |
expression,represses |
R5906 |
T10148 |
T10147 |
prep |
of,expression |
R5907 |
T10149 |
T10150 |
compound |
mouse,Ndrg1 |
R5908 |
T10150 |
T10148 |
pobj |
Ndrg1,of |
R5909 |
T10151 |
T10152 |
punct |
(,51 |
R5910 |
T10152 |
T10118 |
parataxis |
51,named |
R5911 |
T10153 |
T10152 |
punct |
),51 |
R5912 |
T10154 |
T10118 |
punct |
.,named |
R5913 |
T10156 |
T10157 |
nsubjpass |
Transcription,induced |
R5914 |
T10158 |
T10156 |
prep |
of,Transcription |
R5915 |
T10159 |
T10158 |
pobj |
Ndrg1,of |
R5916 |
T10160 |
T10159 |
cc |
and,Ndrg1 |
R5917 |
T10161 |
T10160 |
punct |
/,and |
R5918 |
T10162 |
T10160 |
cc |
or,and |
R5919 |
T10163 |
T10164 |
poss |
its,ortholog |
R5920 |
T10164 |
T10159 |
conj |
ortholog,Ndrg1 |
R5921 |
T10165 |
T10164 |
amod |
human,ortholog |
R5922 |
T10166 |
T10157 |
auxpass |
is,induced |
R5923 |
T10167 |
T10157 |
agent |
by,induced |
R5924 |
T10168 |
T10169 |
amod |
different,conditions |
R5925 |
T10169 |
T10167 |
pobj |
conditions,by |
R5926 |
T10170 |
T10169 |
amod |
physiological,conditions |
R5927 |
T10171 |
T10170 |
cc |
and,physiological |
R5928 |
T10172 |
T10173 |
compound |
cell,stress |
R5929 |
T10173 |
T10170 |
conj |
stress,physiological |
R5930 |
T10174 |
T10169 |
punct |
", ",conditions |
R5931 |
T10175 |
T10176 |
amod |
such,as |
R5932 |
T10176 |
T10169 |
prep |
as,conditions |
R5933 |
T10177 |
T10176 |
pobj |
androgens,as |
R5934 |
T10178 |
T10177 |
punct |
", ",androgens |
R5935 |
T10179 |
T10180 |
compound |
nickel,compounds |
R5936 |
T10180 |
T10177 |
conj |
compounds,androgens |
R5937 |
T10181 |
T10180 |
punct |
", ",compounds |
R5938 |
T10182 |
T10180 |
conj |
DNA,compounds |
R5939 |
T10183 |
T10182 |
nmod |
damage,DNA |
R5940 |
T10184 |
T10182 |
cc |
and,DNA |
R5941 |
T10185 |
T10182 |
conj |
hypoxia,DNA |
R5942 |
T10186 |
T10187 |
punct |
(,53 |
R5943 |
T10187 |
T10185 |
parataxis |
53,hypoxia |
R5944 |
T10188 |
T10187 |
dep |
37,53 |
R5945 |
T10189 |
T10190 |
punct |
–,40 |
R5946 |
T10190 |
T10188 |
prep |
40,37 |
R5947 |
T10191 |
T10187 |
punct |
",",53 |
R5948 |
T10192 |
T10187 |
dep |
52,53 |
R5949 |
T10193 |
T10187 |
punct |
",",53 |
R5950 |
T10194 |
T10187 |
punct |
),53 |
R5951 |
T10195 |
T10157 |
punct |
.,induced |
R5952 |
T10197 |
T10198 |
prep |
In,overexpressed |
R5953 |
T10199 |
T10197 |
pobj |
addition,In |
R5954 |
T10200 |
T10198 |
punct |
", ",overexpressed |
R5955 |
T10201 |
T10202 |
det |
the,protein |
R5956 |
T10202 |
T10198 |
nsubjpass |
protein,overexpressed |
R5957 |
T10203 |
T10198 |
auxpass |
is,overexpressed |
R5958 |
T10204 |
T10198 |
prep |
in,overexpressed |
R5959 |
T10205 |
T10206 |
amod |
human,cancers |
R5960 |
T10206 |
T10204 |
pobj |
cancers,in |
R5961 |
T10207 |
T10206 |
prep |
of,cancers |
R5962 |
T10208 |
T10209 |
amod |
many,tissues |
R5963 |
T10209 |
T10207 |
pobj |
tissues,of |
R5964 |
T10210 |
T10209 |
punct |
", ",tissues |
R5965 |
T10211 |
T10212 |
amod |
such,as |
R5966 |
T10212 |
T10209 |
prep |
as,tissues |
R5967 |
T10213 |
T10212 |
pobj |
lung,as |
R5968 |
T10214 |
T10213 |
punct |
", ",lung |
R5969 |
T10215 |
T10213 |
conj |
liver,lung |
R5970 |
T10216 |
T10215 |
punct |
", ",liver |
R5971 |
T10217 |
T10215 |
conj |
brain,liver |
R5972 |
T10218 |
T10217 |
punct |
", ",brain |
R5973 |
T10219 |
T10217 |
conj |
breast,brain |
R5974 |
T10220 |
T10219 |
punct |
", ",breast |
R5975 |
T10221 |
T10219 |
conj |
kidney,breast |
R5976 |
T10222 |
T10221 |
cc |
and,kidney |
R5977 |
T10223 |
T10221 |
conj |
skin,kidney |
R5978 |
T10224 |
T10225 |
punct |
(,40 |
R5979 |
T10225 |
T10198 |
parataxis |
40,overexpressed |
R5980 |
T10226 |
T10225 |
punct |
),40 |
R5981 |
T10227 |
T10198 |
punct |
.,overexpressed |
R5982 |
T10229 |
T10230 |
mark |
Although,studied |
R5983 |
T10230 |
T10241 |
advcl |
studied,remains |
R5984 |
T10231 |
T10230 |
nsubjpass |
Ndrg1,studied |
R5985 |
T10232 |
T10231 |
cc |
and,Ndrg1 |
R5986 |
T10233 |
T10234 |
advmod |
especially,ortholog |
R5987 |
T10234 |
T10231 |
conj |
ortholog,Ndrg1 |
R5988 |
T10235 |
T10234 |
poss |
its,ortholog |
R5989 |
T10236 |
T10234 |
amod |
human,ortholog |
R5990 |
T10237 |
T10230 |
aux |
have,studied |
R5991 |
T10238 |
T10230 |
auxpass |
been,studied |
R5992 |
T10239 |
T10240 |
advmod |
quite,intensely |
R5993 |
T10240 |
T10230 |
advmod |
intensely,studied |
R5994 |
T10241 |
T10245 |
ccomp |
remains,suggests |
R5995 |
T10242 |
T10241 |
punct |
", ",remains |
R5996 |
T10243 |
T10244 |
poss |
its,function |
R5997 |
T10244 |
T10241 |
nsubj |
function,remains |
R5998 |
T10246 |
T10241 |
acomp |
unclear,remains |
R5999 |
T10247 |
T10245 |
punct |
;,suggests |
R6000 |
T10248 |
T10245 |
advmod |
however,suggests |
R6001 |
T10249 |
T10245 |
punct |
", ",suggests |
R6002 |
T10250 |
T10251 |
det |
the,induction |
R6003 |
T10251 |
T10245 |
nsubj |
induction,suggests |
R6004 |
T10252 |
T10251 |
prep |
by,induction |
R6005 |
T10253 |
T10252 |
pobj |
stimuli,by |
R6006 |
T10254 |
T10253 |
prep |
like,stimuli |
R6007 |
T10255 |
T10254 |
pobj |
nickel,like |
R6008 |
T10256 |
T10255 |
cc |
and,nickel |
R6009 |
T10257 |
T10255 |
conj |
hypoxia,nickel |
R6010 |
T10258 |
T10259 |
det |
an,involvement |
R6011 |
T10259 |
T10245 |
dobj |
involvement,suggests |
R6012 |
T10260 |
T10259 |
prep |
in,involvement |
R6013 |
T10261 |
T10262 |
det |
the,response |
R6014 |
T10262 |
T10260 |
pobj |
response,in |
R6015 |
T10263 |
T10262 |
compound |
cell,response |
R6016 |
T10264 |
T10262 |
compound |
stress,response |
R6017 |
T10265 |
T10245 |
punct |
.,suggests |
R6018 |
T10267 |
T10268 |
predet |
Such,role |
R6019 |
T10268 |
T10270 |
nsubjpass |
role,endorsed |
R6020 |
T10269 |
T10268 |
det |
a,role |
R6021 |
T10271 |
T10270 |
auxpass |
is,endorsed |
R6022 |
T10272 |
T10270 |
advmod |
strongly,endorsed |
R6023 |
T10273 |
T10270 |
agent |
by,endorsed |
R6024 |
T10274 |
T10275 |
poss |
our,finding |
R6025 |
T10275 |
T10273 |
pobj |
finding,by |
R6026 |
T10276 |
T10277 |
mark |
that,induced |
R6027 |
T10277 |
T10275 |
advcl |
induced,finding |
R6028 |
T10278 |
T10279 |
compound |
Ndrg1,expression |
R6029 |
T10279 |
T10277 |
nsubjpass |
expression,induced |
R6030 |
T10280 |
T10279 |
compound |
gene,expression |
R6031 |
T10281 |
T10277 |
auxpass |
is,induced |
R6032 |
T10282 |
T10277 |
advmod |
also,induced |
R6033 |
T10283 |
T10277 |
agent |
by,induced |
R6034 |
T10284 |
T10283 |
pobj |
cadmium,by |
R6035 |
T10285 |
T10277 |
punct |
", ",induced |
R6036 |
T10286 |
T10277 |
cc |
and,induced |
R6037 |
T10287 |
T10288 |
mark |
that,plays |
R6038 |
T10288 |
T10277 |
conj |
plays,induced |
R6039 |
T10289 |
T10288 |
nsubj |
MTF,plays |
R6040 |
T10290 |
T10289 |
punct |
-,MTF |
R6041 |
T10291 |
T10289 |
nummod |
1,MTF |
R6042 |
T10292 |
T10293 |
det |
a,role |
R6043 |
T10293 |
T10288 |
dobj |
role,plays |
R6044 |
T10294 |
T10293 |
amod |
crucial,role |
R6045 |
T10295 |
T10288 |
prep |
in,plays |
R6046 |
T10296 |
T10297 |
det |
this,induction |
R6047 |
T10297 |
T10295 |
pobj |
induction,in |
R6048 |
T10298 |
T10270 |
punct |
.,endorsed |