PMC:1208879 / 15768-16045
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1208879","sourcedb":"PMC","sourceid":"1208879","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1208879","text":" This frame-shifting deletion occurs just before the PAX6 stop codon and is predicted to cause translational read-through into the 3' untranslated region, generating a protein in which the last 5 amino acids of the C-terminal peptide are replaced by a 103 amino acid-extension.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T4005","span":{"begin":276,"end":277},"obj":"."},{"id":"T4004","span":{"begin":266,"end":267},"obj":"HYPH"},{"id":"T4003","span":{"begin":256,"end":261},"obj":"NN"},{"id":"T4002","span":{"begin":262,"end":266},"obj":"NN"},{"id":"T4001","span":{"begin":252,"end":255},"obj":"CD"},{"id":"T4000","span":{"begin":267,"end":276},"obj":"NN"},{"id":"T3999","span":{"begin":250,"end":251},"obj":"DT"},{"id":"T3998","span":{"begin":247,"end":249},"obj":"IN"},{"id":"T3997","span":{"begin":234,"end":237},"obj":"VBP"},{"id":"T3996","span":{"begin":216,"end":217},"obj":"HYPH"},{"id":"T3995","span":{"begin":217,"end":225},"obj":"JJ"},{"id":"T3994","span":{"begin":215,"end":216},"obj":"NN"},{"id":"T3993","span":{"begin":226,"end":233},"obj":"NN"},{"id":"T3992","span":{"begin":211,"end":214},"obj":"DT"},{"id":"T3991","span":{"begin":208,"end":210},"obj":"IN"},{"id":"T3990","span":{"begin":196,"end":201},"obj":"NN"},{"id":"T3989","span":{"begin":194,"end":195},"obj":"CD"},{"id":"T3988","span":{"begin":189,"end":193},"obj":"JJ"},{"id":"T3987","span":{"begin":202,"end":207},"obj":"NNS"},{"id":"T3986","span":{"begin":185,"end":188},"obj":"DT"},{"id":"T3985","span":{"begin":179,"end":184},"obj":"WDT"},{"id":"T3984","span":{"begin":238,"end":246},"obj":"VBN"},{"id":"T3983","span":{"begin":176,"end":178},"obj":"IN"},{"id":"T3982","span":{"begin":168,"end":175},"obj":"NN"},{"id":"T3981","span":{"begin":166,"end":167},"obj":"DT"},{"id":"T3980","span":{"begin":155,"end":165},"obj":"VBG"},{"id":"T3979","span":{"begin":153,"end":155},"obj":","},{"id":"T3978","span":{"begin":134,"end":146},"obj":"JJ"},{"id":"T3977","span":{"begin":132,"end":133},"obj":"SYM"},{"id":"T3976","span":{"begin":131,"end":132},"obj":"CD"},{"id":"T3975","span":{"begin":147,"end":153},"obj":"NN"},{"id":"T3974","span":{"begin":127,"end":130},"obj":"DT"},{"id":"T3973","span":{"begin":122,"end":126},"obj":"IN"},{"id":"T3972","span":{"begin":113,"end":114},"obj":"HYPH"},{"id":"T3971","span":{"begin":109,"end":113},"obj":"NN"},{"id":"T3970","span":{"begin":114,"end":121},"obj":"NN"},{"id":"T3969","span":{"begin":95,"end":108},"obj":"JJ"},{"id":"T3968","span":{"begin":89,"end":94},"obj":"VB"},{"id":"T3967","span":{"begin":86,"end":88},"obj":"TO"},{"id":"T3966","span":{"begin":76,"end":85},"obj":"VBN"},{"id":"T3965","span":{"begin":73,"end":75},"obj":"VBZ"},{"id":"T3964","span":{"begin":69,"end":72},"obj":"CC"},{"id":"T3963","span":{"begin":58,"end":62},"obj":"NN"},{"id":"T3962","span":{"begin":53,"end":57},"obj":"NN"},{"id":"T3961","span":{"begin":63,"end":68},"obj":"NN"},{"id":"T3960","span":{"begin":49,"end":52},"obj":"DT"},{"id":"T3959","span":{"begin":42,"end":48},"obj":"IN"},{"id":"T3958","span":{"begin":37,"end":41},"obj":"RB"},{"id":"T3957","span":{"begin":30,"end":36},"obj":"VBZ"},{"id":"T3956","span":{"begin":11,"end":12},"obj":"HYPH"},{"id":"T3955","span":{"begin":12,"end":20},"obj":"VBG"},{"id":"T3954","span":{"begin":6,"end":11},"obj":"NN"},{"id":"T3953","span":{"begin":21,"end":29},"obj":"NN"},{"id":"T3952","span":{"begin":1,"end":5},"obj":"DT"},{"id":"T3951","span":{"begin":0,"end":277},"obj":"sentence"}],"relations":[{"id":"R2431","pred":"det","subj":"T3952","obj":"T3953"},{"id":"R2432","pred":"nsubj","subj":"T3953","obj":"T3957"},{"id":"R2433","pred":"npadvmod","subj":"T3954","obj":"T3955"},{"id":"R2434","pred":"amod","subj":"T3955","obj":"T3953"},{"id":"R2435","pred":"punct","subj":"T3956","obj":"T3955"},{"id":"R2436","pred":"advmod","subj":"T3958","obj":"T3959"},{"id":"R2437","pred":"prep","subj":"T3959","obj":"T3957"},{"id":"R2438","pred":"det","subj":"T3960","obj":"T3961"},{"id":"R2439","pred":"pobj","subj":"T3961","obj":"T3959"},{"id":"R2440","pred":"compound","subj":"T3962","obj":"T3961"},{"id":"R2441","pred":"compound","subj":"T3963","obj":"T3961"},{"id":"R2442","pred":"cc","subj":"T3964","obj":"T3957"},{"id":"R2443","pred":"auxpass","subj":"T3965","obj":"T3966"},{"id":"R2444","pred":"conj","subj":"T3966","obj":"T3957"},{"id":"R2445","pred":"aux","subj":"T3967","obj":"T3968"},{"id":"R2446","pred":"xcomp","subj":"T3968","obj":"T3966"},{"id":"R2447","pred":"amod","subj":"T3969","obj":"T3970"},{"id":"R2448","pred":"dobj","subj":"T3970","obj":"T3968"},{"id":"R2449","pred":"compound","subj":"T3971","obj":"T3970"},{"id":"R2450","pred":"punct","subj":"T3972","obj":"T3970"},{"id":"R2451","pred":"prep","subj":"T3973","obj":"T3970"},{"id":"R2452","pred":"det","subj":"T3974","obj":"T3975"},{"id":"R2453","pred":"pobj","subj":"T3975","obj":"T3973"},{"id":"R2454","pred":"nummod","subj":"T3976","obj":"T3975"},{"id":"R2455","pred":"punct","subj":"T3977","obj":"T3976"},{"id":"R2456","pred":"amod","subj":"T3978","obj":"T3975"},{"id":"R2457","pred":"punct","subj":"T3979","obj":"T3968"},{"id":"R2458","pred":"advcl","subj":"T3980","obj":"T3968"},{"id":"R2459","pred":"det","subj":"T3981","obj":"T3982"},{"id":"R2460","pred":"dobj","subj":"T3982","obj":"T3980"},{"id":"R2461","pred":"prep","subj":"T3983","obj":"T3984"},{"id":"R2462","pred":"relcl","subj":"T3984","obj":"T3982"},{"id":"R2463","pred":"pobj","subj":"T3985","obj":"T3983"},{"id":"R2464","pred":"det","subj":"T3986","obj":"T3987"},{"id":"R2465","pred":"nsubjpass","subj":"T3987","obj":"T3984"},{"id":"R2466","pred":"amod","subj":"T3988","obj":"T3987"},{"id":"R2467","pred":"nummod","subj":"T3989","obj":"T3987"},{"id":"R2468","pred":"compound","subj":"T3990","obj":"T3987"},{"id":"R2469","pred":"prep","subj":"T3991","obj":"T3987"},{"id":"R2470","pred":"det","subj":"T3992","obj":"T3993"},{"id":"R2471","pred":"pobj","subj":"T3993","obj":"T3991"},{"id":"R2472","pred":"npadvmod","subj":"T3994","obj":"T3995"},{"id":"R2473","pred":"amod","subj":"T3995","obj":"T3993"},{"id":"R2474","pred":"punct","subj":"T3996","obj":"T3995"},{"id":"R2475","pred":"auxpass","subj":"T3997","obj":"T3984"},{"id":"R2476","pred":"agent","subj":"T3998","obj":"T3984"},{"id":"R2477","pred":"det","subj":"T3999","obj":"T4000"},{"id":"R2478","pred":"pobj","subj":"T4000","obj":"T3998"},{"id":"R2479","pred":"nummod","subj":"T4001","obj":"T4002"},{"id":"R2480","pred":"compound","subj":"T4002","obj":"T4000"},{"id":"R2481","pred":"compound","subj":"T4003","obj":"T4002"},{"id":"R2482","pred":"punct","subj":"T4004","obj":"T4000"},{"id":"R2483","pred":"punct","subj":"T4005","obj":"T3957"}],"attributes":[{"subj":"T4005","pred":"source","obj":"craft-sa-dev"},{"subj":"T4004","pred":"source","obj":"craft-sa-dev"},{"subj":"T4003","pred":"source","obj":"craft-sa-dev"},{"subj":"T4002","pred":"source","obj":"craft-sa-dev"},{"subj":"T4001","pred":"source","obj":"craft-sa-dev"},{"subj":"T4000","pred":"source","obj":"craft-sa-dev"},{"subj":"T3999","pred":"source","obj":"craft-sa-dev"},{"subj":"T3998","pred":"source","obj":"craft-sa-dev"},{"subj":"T3997","pred":"source","obj":"craft-sa-dev"},{"subj":"T3996","pred":"source","obj":"craft-sa-dev"},{"subj":"T3995","pred":"source","obj":"craft-sa-dev"},{"subj":"T3994","pred":"source","obj":"craft-sa-dev"},{"subj":"T3993","pred":"source","obj":"craft-sa-dev"},{"subj":"T3992","pred":"source","obj":"craft-sa-dev"},{"subj":"T3991","pred":"source","obj":"craft-sa-dev"},{"subj":"T3990","pred":"source","obj":"craft-sa-dev"},{"subj":"T3989","pred":"source","obj":"craft-sa-dev"},{"subj":"T3988","pred":"source","obj":"craft-sa-dev"},{"subj":"T3987","pred":"source","obj":"craft-sa-dev"},{"subj":"T3986","pred":"source","obj":"craft-sa-dev"},{"subj":"T3985","pred":"source","obj":"craft-sa-dev"},{"subj":"T3984","pred":"source","obj":"craft-sa-dev"},{"subj":"T3983","pred":"source","obj":"craft-sa-dev"},{"subj":"T3982","pred":"source","obj":"craft-sa-dev"},{"subj":"T3981","pred":"source","obj":"craft-sa-dev"},{"subj":"T3980","pred":"source","obj":"craft-sa-dev"},{"subj":"T3979","pred":"source","obj":"craft-sa-dev"},{"subj":"T3978","pred":"source","obj":"craft-sa-dev"},{"subj":"T3977","pred":"source","obj":"craft-sa-dev"},{"subj":"T3976","pred":"source","obj":"craft-sa-dev"},{"subj":"T3975","pred":"source","obj":"craft-sa-dev"},{"subj":"T3974","pred":"source","obj":"craft-sa-dev"},{"subj":"T3973","pred":"source","obj":"craft-sa-dev"},{"subj":"T3972","pred":"source","obj":"craft-sa-dev"},{"subj":"T3971","pred":"source","obj":"craft-sa-dev"},{"subj":"T3970","pred":"source","obj":"craft-sa-dev"},{"subj":"T3969","pred":"source","obj":"craft-sa-dev"},{"subj":"T3968","pred":"source","obj":"craft-sa-dev"},{"subj":"T3967","pred":"source","obj":"craft-sa-dev"},{"subj":"T3966","pred":"source","obj":"craft-sa-dev"},{"subj":"T3965","pred":"source","obj":"craft-sa-dev"},{"subj":"T3964","pred":"source","obj":"craft-sa-dev"},{"subj":"T3963","pred":"source","obj":"craft-sa-dev"},{"subj":"T3962","pred":"source","obj":"craft-sa-dev"},{"subj":"T3961","pred":"source","obj":"craft-sa-dev"},{"subj":"T3960","pred":"source","obj":"craft-sa-dev"},{"subj":"T3959","pred":"source","obj":"craft-sa-dev"},{"subj":"T3958","pred":"source","obj":"craft-sa-dev"},{"subj":"T3957","pred":"source","obj":"craft-sa-dev"},{"subj":"T3956","pred":"source","obj":"craft-sa-dev"},{"subj":"T3955","pred":"source","obj":"craft-sa-dev"},{"subj":"T3954","pred":"source","obj":"craft-sa-dev"},{"subj":"T3953","pred":"source","obj":"craft-sa-dev"},{"subj":"T3952","pred":"source","obj":"craft-sa-dev"},{"subj":"T3951","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3332","span":{"begin":256,"end":266},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T3331","span":{"begin":238,"end":246},"obj":"SO_EXT:sequence_substitution_process"},{"id":"T3330","span":{"begin":226,"end":233},"obj":"CHEBI_SO_EXT:peptide_or_peptide_region"},{"id":"T3329","span":{"begin":215,"end":225},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T3328","span":{"begin":196,"end":207},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T3327","span":{"begin":168,"end":175},"obj":"CHEBI_PR_EXT:protein"},{"id":"T3326","span":{"begin":136,"end":146},"obj":"GO:0006412"},{"id":"T3325","span":{"begin":131,"end":153},"obj":"SO_EXT:0000205"},{"id":"T3324","span":{"begin":95,"end":121},"obj":"GO:0006451"},{"id":"T3323","span":{"begin":58,"end":68},"obj":"SO_EXT:0000319"},{"id":"T3322","span":{"begin":53,"end":57},"obj":"PR_EXT:000012318"},{"id":"T3321","span":{"begin":21,"end":29},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T3320","span":{"begin":6,"end":20},"obj":"GO_SO_EXT:frameshift_entity_or_process"}],"attributes":[{"subj":"T3332","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3331","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3330","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3329","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3328","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3327","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3326","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3325","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3324","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3323","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3322","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3321","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3320","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T3193","span":{"begin":136,"end":146},"obj":"GO:0006412"},{"id":"T3192","span":{"begin":131,"end":153},"obj":"SO:0000205"},{"id":"T3191","span":{"begin":95,"end":121},"obj":"GO:0006451"},{"id":"T3190","span":{"begin":58,"end":68},"obj":"SO:0000319"},{"id":"T3189","span":{"begin":53,"end":57},"obj":"PR:000012318"}],"attributes":[{"subj":"T3193","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T3192","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T3191","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T3190","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T3189","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#eccf93","default":true},{"id":"craft-ca-core-ex-dev","color":"#b593ec"},{"id":"craft-ca-core-dev","color":"#93ec9b"}]}]}}