Figure 5  Some of the Genes Up-Regulated in rd7 Show an Early Photoreceptor Pattern of Expression
Gnb3 and Thrb2 are both previously characterized cone genes that show staining at the scleral edge of the embryonic mouse retina in cells that will differentiate into photoreceptors. Ece1 and Otop3 are two novel cone genes identified in this study that were up-regulated in rd7 and also showed an early photoreceptor pattern of expression. Prdm1 and RIKEN cDNA 1300018I05 (Figure 1, genes G48 and G49, respectively) are two other genes that had either undetectable signal (Prdm1) or no apparent change in expression pattern in adult rd7 mutants (RIKEN cDNA 1300018I05), but which also showed staining in the embryonic retina in a presumptive photoreceptor pattern. All images are from E17.5 retina except Gnb3, which was from E16.