In addition to the ten genes that showed cone-specific expression in the wild-type retina, another 11 novel genes were derepressed in the rd7 retina by in situ hybridization (Figure 1, genes G36–G46). Some of these genes showed faint expression in a cone-like distribution (see Table S1, genes G36, G40, and G44), and one appeared to be expressed throughout the ONL but at greater levels in cones than in rods (Table S1, gene G37). The remainder of the up-regulated genes did not have detectable cone staining in the wild-type retina. Despite this apparent absence of cone staining, the pattern of derepression in rd7 suggests that these genes may also be novel cone-specific genes, albeit expressed at levels below the sensitivity threshold of our in situ hybridization assay.