Table 1 Genotyping of the progeny of Adam22 heterozygous intercrosses. Adam22 genotype +/+ +/- -/- total Day 10 16 43 19 78 Day 15 16 43 8 67 Day 20 16 43 0 59 From heterozygous intercrosses, 78 mice were produced. Numbers of mice in each genotype were counted on postnatal day 10, 15 and 20. No homozygotes were survived more than postnatal day 20. +/+, wild-type; +/-, heterozygote; -/-, homozygote.