Fig 3 shows how LC stimulation increased extracellular NA by 78 and 56%, in the mPFC and Occ, respectively, the levels returning to baseline values within 20 min (ANOVA results: mPFC: F(8,40) = 16.103, P < 0.0001; Occ: F(8,40) = 11.349, P < 0.0001). Extracellular DA concentration in the mPFC increased by 29%, and returned to baseline within 20 min. In the Occ extracellular DA reached a maximal increase of about 54% at 20 min after the end of stimulation and remained elevated by about 30% throughout the experimental period (ANOVA results: mPFC: F(8,40) = 5.043, P = 0.0002; Occ: F(8,40) = 5.386, P = 0.0001).