Clinical changes
We do not perform regular formal ratings of the mood of our patients. However we regularly record their condition and changes since the previous appointment. Clear improvement of the course of illness was noticed only in one patient (N 3), while eight patients continued to display a similar pattern of illness, as they had done before the treatment. None of them was judged to have deteriorated. The patients in remission remained well. One patient (N 12) whose carbamazepine was changed to topiramate developed a manic episode, therefore we stopped his topiramate after 6 months and asked him to resume carbamazepine.