Weight changes
Patients have received topiramate for between 6 months and one year by the time of writing this report. Six of them are still continuing the treatment. The weight changes are shown in Figure 1 and Table 1. All post-treatment levels and the pre-treatment levels from the previous two years, where available, are shown in Figure 1. At 3 and 6 months, 12 patients lost a mean of 4.96 and 7.75 kg respectively. The nine patients who completed 12 months treatment showed a weight loss of 10.2 and 9.61 kg at the 9th and 12th month respectively. All these changes are significant at p < = 0.005.
Figure 1  Weight changes in the patients described in the study. The day of treatment is on the x-axis. The day when topiramate was started is day 0 and weight measurements before that point are supplied where available. Each patient's number as referred to in the text is given on the right of the figure.

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