Topiramate dosage
Topiramate dose was increased in steps of 25–50 mg every one to two weeks. After some of the first patients complained of paraesthesia and headaches, we routinely started making the increases only at 2-weekly intervals. The final dose of topiramate ranged between 200 and 600 mg, with a mean of 296 mg. The dose was increased until we could see a clear effect on the weight, or the patient reported some side effects. The patient whose topiramate was increased to 600 mg/day suffers with poorly controlled epilepsy and we increased the dose in order to achieve a better seizures control, rather than weight loss.