Competing interests DA has competing interests with the US Preventive Services Task Force (USPSTF), PAB has a competing interest with the US Task Force on Community Preventive Services (USTFCPS), ME has and JM had competing interests with the National Institute for Clinical Excellence (NICE), GHG, RJ and HS have competing interests with the American College of Chest Physicians (ACCP), RTH has competing interests with the Scottish Intercollegiate Guidelines Network (SIGN), SH and DO'C have competing interests with the Australian National Health and Medical Research Council (ANHMRC), BP has competing interests with the Oxford Centre for Evidence-Based Medicine (OCEBM). Most of the other members of the GRADE Working Group have experience with the use of one or more systems for grading evidence and recommendations.