Table 9  Example of a modified GRADE evidence profile quality assessment. Table 9 and 10 is what Table 1 and 2 became when including the improvements made based on the pilot study experience. 
Question: Should depressed patients be treated with SSRIs rather than tricyclics?
Setting: Primary care 
Patients: Moderately depressed adult patients 
Reference: North of England Evidence Based Guideline Development Project. Evidence based clinical practice guideline: the choice of antidepressants for depression in primary care. Newcastle upon Tyne: Centre for Health Services Research, 1997.  *There was uncertainty about the directness of the outcome measure because of the short duration of the trials.
**It is possible that people at lower risk were more likely to have been given SSRI's and it is uncertain if changing antidepressant would have deterred suicide attempts.
SD = Sparse data (Yes or No)
SA = Strong association (No, + = strong, ++ = very strong)
RB = Reporting bias (Yes or No)
DR = Dose response (Yes or No)
PC = All plausible confounders would have reduced the effect (Yes or No)
CI = confidence interval
WMD = weighted mean difference
RRR = relative risk reduction