Relative importance of each outcome
Specification of outcomes in the question that each example addressed resulted in some confusion regarding the relative importance of each outcome and the overall quality of evidence across outcomes. We therefore agreed that outcomes should not be included in the questions and that all important outcomes should be considered. There was good agreement about the relative importance of the 48 outcomes that were considered. We reached a consensus about the relative importance of all but two of the outcomes. This was due to uncertainty and true disagreement about the importance of these two outcomes, dental fluorosis and bone fractures, in relation to the question about water fluoridation.