Figure 10  Neuropathology of the Central Nervous System of PGC-1α−/− Mice
(A) Light microscopic appearance of representative cerebral cortex of 2-mo-old PGC-1α−/− mice demonstrates marked vacuolation of the neuropil (arrows) and scattered neuronal perikarya, which are absent in PGC-1α+/+ mice (hematoxylin and eosin). The scale bar shown is applicable to all sections.
(B) Ultrastructural appearance of typical vacuoles containing membranous debris, denoted by the arrow, in the cerebral cortex of a representative PGC-1α−/− mouse in comparison to PGC-1α+/+ (magnification 4000×).