Figure 9  Female PGC-1α−/− Mice Are More Glucose Tolerant and Insulin Sensitive Compared to PGC-1α+/+ on High-Fat Diet
(A) At 4.5 mo of age, glucose tolerance testing (GTT) was performed on female PGC-1α+/+ (n = 6) and PGC-1α−/− (n = 6) mice maintained on standard chow.
(B) At 8 wk of age, PGC-1α+/+ (n = 8) and PGC-1α−/− (n = 11) mice were provided a diet containing 43% of its calories from fat (HF chow). The graphs depict blood glucose levels ± SEM in PGC-1α−/− mice during GTT (left graph) and ITT (right graph) studies. Studies were performed 5 wk (GTT) and 6 wk (ITT) after the initiation of the high-fat diet. * p < 0.05 compared to PGC-1α+/+ mice at the same time point.