Figure 7  Fasting-Induced Hepatic Steatosis Develops in PGC-1α−/− Mice
(A) The photograph depicts the development of a pale liver in PGC-1α−/− mice subjected to a 24-h fast.
(B) Oil red O staining of histologic sections of liver taken from PGC-1α−/− mice under fed and 24 h fasted conditions. The red staining indicates neutral lipid.
(C) Representative electron micrographs of the liver from PGC-1α+/+ and PGC-1α−/− mice following a 24-h fast. The droplets are indicative of neutral lipid accumulation.
(D) Mean liver TAG levels in PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) mice under fed and 24-h fasted conditions. * p < 0.05.