In fact, an antagonizing action or the counter-regulation of AT 2 -receptor stimulation has been reported previously. [13] [14] [15] ROLES OF ACE2, ANG-(1-7) AND THE MAS AXIS-A NEW RAS PATHWAY Possible effects such as vasodilation mediated by Ang-(1-7) have been reported; however, the mechanisms leading to Ang-(1-7) production and its receptor were unclear, resulting in the delay of Ang-(1-7)based researches.