Ang II binds to two major types of receptors, namely, Ang II type 1 (AT 1 ) and Ang II type 2 (AT 2 ) receptors, 1 the signaling pathways of which have been well studied, including in the identification of new signalingrelated molecules, such as AT 1 receptor-associated protein (ATRAP) 2 and AT 2 receptor-interacting protein (ATIP).