In agreement with this hypothesis, a molten globular character was described for circularly permuted dihydrofolate reductase (DHFR), 196, 197 and urease G from Bacillus pasteurii (BpUreG). [198] [199] [200] Of these three enzymatic molten globules UreG is the only natural molten globular enzyme known to date, since both circularly permuted DHFR and monomeric MjCM were obtained as a result of some genetic manipulations.