11, 13, 15, 71, 72, 78, 79, [130] [131] [132] 134, [154] [155] [156] [157] When disordered regions bind to signaling partners, the free energy required to bring about the disorder to order transition takes away from the interfacial, contact free energy, with the net result that a highly specific interaction can be combined with a low net free energy of association.