To treat toxicity, administer activated charcoal, intravenous fluids to promote diuresis and treat hyperthermia, chlorpromazine to combat α-adrenergic effects, a β-blocker (propranolol, 0.04 to 0.1 mg/kg IV slowly to effect; esmolol, 50 to 100 mcg/kg IV bolus, 50 to 200 mcg/kg/min IV CRI; atenolol, 0.5 to 1 mg/kg PO q12h [canine], 6.25 to 12.5 mg/cat PO q12-24h [feline]) to treat β-adrenergic effects, and cyproheptadine (0.5 to 1.1 mg/kg POq12h or per rectum dog, 2 mg/k cat PO or per rectum) to combat serotoninergic effects.