Casqueiro et al. [30] concluded that the infectious diseases are more frequent and/or serious in patients with DM, which potentially increases their morbidity and mortality due to many factors as a deficiency of the C4 component in DM, this reduction of C4 is probably associated with polymorphonuclear dysfunction and reduced cytokine response decrease secretion of inflammatory cytokines as interleukin-1 (IL-1) and IL-6 decreased mobilization of polymorphonuclear leukocytes, chemotaxis and phagocytic activity.