The antihyperglycemic activity of pyrazolone derivatives was explored by Kees et al. [130] The potent compound 173 (100 mg/kg) (Fig. 18 ) caused a 68% decrease in plasma glucose in db/db mice, moreover, it essentially normalized the level of glucose at 20 mg/kg (57% reduction) and maintained remarkable reduction at 2 mg/kg (30% decrease).