CORD-19:cb16d307afaecebd683e6d74c8b501ed54b0c9a4 / 35221-35606 JSONTXT

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T206","span":{"begin":0,"end":385},"obj":"Sentence"},{"id":"T47377","span":{"begin":0,"end":385},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Among them, compound 113 ( Fig. 9 ) was the typical compound with the affinity of IC 50 values of a1 GABA A receptor, a2 GABA A receptor, a1 GABA A BZ receptor, a2 GABA A BZ receptor for 49, 271, 46 and 271 nM, respectively, however, the weak activity of compound 113 was observed in anxiety models in vivo, which was suspected due to the high level of clearance (in vitro: CL int rat:"}

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T47","span":{"begin":284,"end":291},"obj":"Disease"},{"id":"T17426","span":{"begin":284,"end":291},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005618"},{"id":"A48","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0011918"},{"id":"A15931","pred":"mondo_id","subj":"T17426","obj":"http://purl.obolibrary.org/obo/MONDO_0005618"},{"id":"A83768","pred":"mondo_id","subj":"T17426","obj":"http://purl.obolibrary.org/obo/MONDO_0011918"}],"text":"Among them, compound 113 ( Fig. 9 ) was the typical compound with the affinity of IC 50 values of a1 GABA A receptor, a2 GABA A receptor, a1 GABA A BZ receptor, a2 GABA A BZ receptor for 49, 271, 46 and 271 nM, respectively, however, the weak activity of compound 113 was observed in anxiety models in vivo, which was suspected due to the high level of clearance (in vitro: CL int rat:"}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T206","span":{"begin":0,"end":385},"obj":"Sentence"}],"text":"Among them, compound 113 ( Fig. 9 ) was the typical compound with the affinity of IC 50 values of a1 GABA A receptor, a2 GABA A receptor, a1 GABA A BZ receptor, a2 GABA A BZ receptor for 49, 271, 46 and 271 nM, respectively, however, the weak activity of compound 113 was observed in anxiety models in vivo, which was suspected due to the high level of clearance (in vitro: CL int rat:"}

{"project":"CORD-19-PD-HP","denotations":[{"id":"T39","span":{"begin":284,"end":291},"obj":"Phenotype"}],"attributes":[{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0000739"}],"text":"Among them, compound 113 ( Fig. 9 ) was the typical compound with the affinity of IC 50 values of a1 GABA A receptor, a2 GABA A receptor, a1 GABA A BZ receptor, a2 GABA A BZ receptor for 49, 271, 46 and 271 nM, respectively, however, the weak activity of compound 113 was observed in anxiety models in vivo, which was suspected due to the high level of clearance (in vitro: CL int rat:"}