We selected a laboratory-generated mutant of Staphylococcus epidermidis capable of growing in the presence of 256 mg/l of teicoplanin (353b TM256), from a methicillin-resistant (MIC!/256 mg/l), teicoplanin-sensitive (MIC 4 mg/l) and vancomycin-sensitive (MIC 2 mg/l) clinical isolate of S. epidermidis (353b SO).