Causes of non-made LB are: (1) refusal from patients because of biopsy's fear0/ 35.3%; (2) contraindications because of HIV infection0/33.8% (clinical events0/16.2% which contraindicate anti-HCV treatment, grade III thrombocytopenia0/8.8% which contraindicate biopsy, non-adherence to previous HIV follow up0/8.8%); (3) other0/30.9% (alcoholism0/13.2%, psychiatric/depressive disorders0/11.8%, decompensated cirrhosis0/5.9%).