Imaging and biochemical characterization of nidovirus nsps have shown that they are targeted to specific virus-induced membrane structures (reviewed in (Hagemeijer et al., 2012; Neuman et al., 2014; van der Hoeven et al., 2016) ) where they assemble into a so-called replication and transcription complex (RTC; see (Neuman et al., 2014; Snijder et al., 2016; Subissi et al., 2014a) for reviews).