Conclusions: (a) IL-10-DC differently affect EAMG vs. MG in terms of T cell activation, and Th1/Th2 cytokine production; (b) IL-10-DC in MG have pronounced costimulatory capacity for Th2 cells, reflected by increased CD4 + CD25 + T cells expressing CD69 and increased production of IL-10 and IL-4, compared to IL-10-DC from HC.