Effects of antigen-specific tolerance of CD8+ T-cells on a viral infection of the central nervous system M. Teague and S. Miller Northwestern University, Chicago, Illinois, USA Antigen-specific tolerance of CD4+ T-cells induced by the injection of antigen coupled, ECDI-fixed cells into recipient mice is a procedure that has been pursued as a possible therapy for autoimmune diseases, as it prevents and/or ameliorates several CD4+ T-cell mediated diseases in mice.