Figure 3C and 3D show that the two Man9 clusters captured substantially increased levels of IgGs compared to those detected by their common KLH carrier molecule. [(Man9)4]n-KLH preserves well the HIV-1-specific Man9-glyco-epitopes recognized by 2G12. (Man9) n-KLH is poorly reactive with 2G12 but is highly reactive with the anti-tumor mAb TM10.