During the intervention period, we implemented a multidisciplinary care bundle consisted of (1) hand hygiene, (2) use of maximum barrier precautions, (3) use of 2% chlorhexidine scrub for the insertion site, (4) head-of-bed elevation 30°-45°, (5) education of providers, (6) a dedicated line cart, (7) checklist, (8) oral care with chlorhexidine solution twice daily, and (9) daily consideration of the need for the catheter and so many measures.