The disclosed risk factors of sputum isolation of ESBLproducing E. coli and K. pneumonia are as follows; low BMI (P = 0.0195), antibiotic use history (P = 0.0495), ESBL isolation history (P = 0.0004), high Charlson Comorbidity Index (P = 0.0262), and high quick SOFA (P = 0.0376).