Whereas ACE removes dipeptides from the C-terminus of peptide substrates, generating the octapeptide ANG II from the decapeptide ANG I [3, 15] , ACE2 cleaves a single residue from ANG II, generating angiotensin-(1-9) [12, 13] , and a single residue from ANG II to generate angiotensin-(1-7) [12] .