We studied forty adult patients in a randomized open labeled 2-week trial to compare the efficacy of the combination nasal Azelastine and Fluticasone propionate (137mcg/50 mcg), one spray per nostril twice daily, with an oral antibiotic Amoxicillin/Clavulanate potassium (875mg/125mg) every 12 hours, for the treatment of otitis media with effusion.