In E tissue, we observed: i) a BBB disruption and IgG diffusion into the parenchyma, ii) an IgG accumulation in pyramidal neurons and in few astrocytes, iii) an abundant immunoreactivity for HLA proteins in macrophage-like cells, localized around blood vessels, iv) the presence of C3c positive perivascular infiltrates, and v) C5b-C9 (MAC) deposits in cells displaying a microglia/macrophage morphology.